There are currently 34 active clinical trials seeking participants for Metabolic Syndrome research studies. The states with the highest number of trials for Metabolic Syndrome participants are California, Ontario, Quebec and Massachusetts.
Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function
NCT06078683
Recruiting
This study is being done to evaluate how a ketone ester (KE) beverage affects heart function and health in people with heart failure compared to a placebo beverage (a beverage made with standard food ingredients that do not contain ketone esters).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/11/2025
Locations: The Ross Heart Hospital, Columbus, Ohio
Conditions: Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Metabolic Syndrome
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Study of the Effect of Innate on the Inflammatory Response to Endotoxin
NCT01143480
Recruiting
Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: - To examine how specific genes and proteins in blood cells respond to environmental e... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/13/2025
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance, Cancer
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Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
NCT07106879
Recruiting
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials. A physician will oversee the informed consent process, after which participants will be surveyed on demographics, medical history, current health conditions and symptoms. The study team may also collect basic health information, including vital signs, urine drug tests, blood samples and pregnancy tests (if applicable). A physician will review... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2025
Locations: Clindove Research LLC, Brooklyn, New York
Conditions: Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes, Mental Health Disorders, Endocrine Dysfunction, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease (CKD)
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Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial
NCT07119658
Recruiting
The objective of this study is to pilot a multifaceted, optimized intervention for metabolic syndrome (MetS) in emergency department patients to establish feasibility. Participants (n=20) will be randomized to intervention or control (usual care). The composite intervention will include an educational video outlining the adverse effects of MetS and the benefit of walking, a written exercise prescription with a defined goal of walking 150 minutes per week, a Fitbit accelerometer device, resources... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2025
Locations: Sidney & Lois Eskenazi Hospital, Indianapolis, Indiana
Conditions: Hypertension, Hyperglycemia, Dyslipidemia, Metabolic Syndrome, Obesity &Amp; Overweight, Diabetes, Hyperlipidemia, Emergency Medicine
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Impact GLP-1 Agonists Following Bariatric
NCT06132477
Recruiting
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic health of a person. GLP-1 receptor agonists (GLP1-RAs) have been shown to be effective in achieving weight loss in patients with type 2 diabetes while improving blood glucose control. Bariatric surgical procedures have been shown to be effective in treating obesity as w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: University of Missouri Hospital, Columbia, Missouri
Conditions: Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension, Obstructive Sleep Apnea of Adult
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Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
NCT07095426
Recruiting
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/24/2025
Locations: Health Professions Building, Muncie, Indiana
Conditions: Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
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Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women
NCT06827704
Recruiting
This study aims to to improve physical activity and metabolic outcomes for breast cancer prevention in South Asian Indian immigrant women.
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
07/23/2025
Locations: Rush University College of Nursing, Chicago, Illinois +1 locations
Conditions: Metabolic Syndrome, Breast Cancer Prevention, Physical Activity
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Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
NCT06049420
Recruiting
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, wellness programs and similar resources that are more available in urban areas. Although pharmaceutical therapies have continued to show therapeutic advancements, the rates of disease onset and death from c... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
07/21/2025
Locations: West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia
Conditions: Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension, Coronary Heart Disease, Heart Failure, Depression, Anxiety, Type II Diabetes, Metabolic Syndrome
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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NCT06112418
Recruiting
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/15/2025
Locations: Chandler Clinical Trials, Chandler, Arizona +93 locations
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
Register for Updates
Exercise Effects on Adipose Tissue Structure and Function
NCT04812314
Recruiting
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the wei... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/25/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain
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Combined Oral Contraceptive Pill and Resistance Starch
NCT06852365
Recruiting
This study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of placebo to explore if resistant starch improves cardiometabolic parameters or impacts gut dysbiosis compared to placebo.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
06/11/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Metabolic Syndrome, Polycystic Ovary Syndrome
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Exercise and Time of Day in Type 2 Diabetes
NCT05108987
Recruiting
The overall purpose of the study is to test the effect of Noom on exercise and diet advice in adults with type 2 diabetes. The overarching hypothesis is that the use of Noom may promote better dietary adherence during an exercise program, thereby promoting greater weight loss and cardiometabolic health compared to lifestyle advice only. In particular, the investigators anticipate that changes in metabolic and vascular insulin sensitivity will correlate with glycemic control and blood pressure ch... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
06/11/2025
Locations: New Jersey Institute for Food, Nutrition, and Health, New Brunswick, New Jersey +2 locations
Conditions: Diabetes Mellitus, Type 2, Metabolic Syndrome
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