The city of Los Angeles, California, currently has 8 active clinical trials seeking participants for Autism research studies.
Effectiveness Trial of Mobile ESI for Toddlers With Autism Identified by Early Screening in Primary Care
Recruiting
The goal of this collaborative R01 is to demonstrate the therapeutic value and community-wide implementability of an early intervention (EI) platform for toddlers with autism spectrum disorder (ASD) that is completely virtual, from recruitment through intervention. This platform-Early Social Interaction Mobile Coaching (ESI-MC) deploys individual telehealth sessions with coaching and feedback to help families embed intervention in everyday activities. Specifically, the investigators will conduct... Read More
Gender:
All
Ages:
Between 15 months and 20 months
Trial Updated:
05/15/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Autism Spectrum Disorder
Evaluating BOSCC and ELSA as Outcome Measures in the Context of a JASPER Intervention Trial
Recruiting
Research teams in Boston University, UCLA, and Weill Cornell will recruit 90 participants in 3 years (10 participants per site per year) and evaluate JASPER, play-based intervention, using the BOSCC and ELSA-T. Participants will be randomized to receive JASPER facilitated either by a clinician or the caregiver. After 10 weeks, the participants will be evaluated using the CGI to determine if they are "responders" or "non-responders". Nonresponders will be given a mix of clinician and caregiver-fa... Read More
Gender:
All
Ages:
Between 18 months and 5 years
Trial Updated:
04/26/2024
Locations: UCLA, Los Angeles, California +1 locations
Conditions: Autism Spectrum Disorder
The Autism Biomarkers Consortium for Clinical Trials: Confirmation Study
Recruiting
This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in clinical trials. The confirmation study will repeat the data collection and analysis protocols from the original ABC-CT study. This confirmation study will recruit 200 ASD and 200 TD comparison participants who are 6-11 years old, matching the overall sampl... Read More
Gender:
All
Ages:
Between 6 years and 11 years
Trial Updated:
03/15/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Autism Spectrum Disorder
Management of ADHD in Autism Spectrum Disorder
Recruiting
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists. Findings from this study will help improve clinicians' approach to me... Read More
Gender:
All
Ages:
Between 4 years and 17 years
Trial Updated:
02/06/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: ADHD, Autism Spectrum Disorder
Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations
Recruiting
The purpose of this study is to determine cross-sectional and longitudinal medical, behavioral, and cognitive differences between PTEN ASD and other groups, as well as to identify cognitive, neural systems, and molecular biomarkers specific to PTEN ASD. In addition, this study will be creating and maintaining a biorepository and linked phenotypic database for PTEN ASD.
Gender:
All
Ages:
18 months and above
Trial Updated:
11/09/2023
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: PTEN, ASD, Autism, Macrocephaly, PTEN Hamartoma Tumor Syndrome
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)
Recruiting
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive of ASD and ID presence and severity in patients with TSC. In addition, this study will be establishing infrastructure for the collection and storage of human bio-specimens, including genetic material, from TSC patients and their family members with ASD.
Gender:
All
Ages:
18 months and above
Trial Updated:
11/09/2023
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Tuberous Sclerosis, Autism Disorder, Intellectual Disability
PRISM Intervention Study
Recruiting
This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status... Read More
Gender:
All
Ages:
Between 36 months and 59 months
Trial Updated:
11/03/2023
Locations: UCLA, Los Angeles, California
Conditions: Autism Spectrum Disorder
Boosting Language Outcomes of Minimally Verbal Children With ASD (BLOOM)
Recruiting
In this project, the investigator will test the effect of augmenting an evidence based joint attention intervention (JASPER) with a motor-sound system intervention (PROMPT) compared to JASPER only on speech and language outcomes. The investigator will model change over a year to determine the percentage of children who cross the hurdle from single words to word combinations by Kindergarten. The proposed research will foster the understanding of the mechanisms underlying speech heterogeneity in A... Read More
Gender:
All
Ages:
Between 48 months and 66 months
Trial Updated:
11/03/2023
Locations: UCLA Semel Institute, Los Angeles, California +1 locations
Conditions: Autism Spectrum Disorder