The city of Stanford, California, currently has 16 active clinical trials seeking participants for Autism research studies.
Pilot Trial of Pregnenolone in Autism
Recruiting
This is a research study to examine the tolerability and effectiveness of pregnenolone in individuals with autism. Pregnenolone is a naturally occurring steroid hormone in the brain that has been implicated in treating various psychiatric conditions. The investigators hope to learn the effects and safety of using pregnenolone in reducing irritability and sensitivity to sensory differences and improving social communication in individuals with autism. The investigators hope by studying the effect... Read More
Gender:
ALL
Ages:
Between 14 years and 25 years
Trial Updated:
02/28/2025
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Autism Spectrum Disorder, Autism
Trial of Diphenhydramine for Sleep in Children With Autism
Recruiting
The purpose of this study is to examine the effect of diphenhydramine on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Diphenhydramine is an anti-histaminergic agent with strong hypnotic properties. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of diphenhydramine on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
02/28/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Parent-Mediated Intervention Targeting Insistence on Sameness for Autistic Children
Recruiting
This study will examine the potential effectiveness of a virtually delivered parent-mediated intervention for insistence on sameness behaviors in autism and investigate 1) whether caregivers can learn to deliver the adapted Supportive Parenting for Anxious Childhood emotions (SPACE) intervention for IS via telehealth and 2) whether children will show greater improvement in IS behaviors.
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
02/21/2025
Locations: Jennifer Phillips, Stanford, California
Conditions: Autism Spectrum Disorder, Autism
Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
Recruiting
Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
02/14/2025
Locations: Stanford University, Stanford, California
Conditions: Autism Spectrum Disorder, Autism, Asperger Syndrome
Trial of Zolpidem for Sleep in Children with Autism
Recruiting
The purpose of this study is to examine the effect of zolpidem on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Zolpidem is a nonbenzodiazepine GABAa receptor agonist drug that acts as a hypnotic. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of zolpidem on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
02/10/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Trial of Suvorexant for Sleep in Children with Autism
Recruiting
The purpose of this study is to examine the effect of suvorexant on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Suvorexant is a selective, dual orexin receptor antagonist (DORA) used for the treatment of sleep onset difficulties and/or sleep maintenance. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of suvorexant on sleep physiology as assessed by polysomnography (PSG), ac... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
02/10/2025
Locations: Stanford University, Stanford, California
Conditions: Autism, Autism Spectrum Disorder
Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
Recruiting
The purpose of this open label trial is to examine the preliminary feasibility, acceptability, and effectiveness of a 12-week behavioral intervention program (1 hour/week) to treat insistence on sameness (e.g., difficulty tolerating changes in routine) in youth with autism spectrum disorder (ASD). Treatment will be delivered via secure telemedicine platform and consist of a combination of parent-training and parent-mediated intervention with the child.
Gender:
ALL
Ages:
Between 4 years and 17 years
Trial Updated:
01/24/2025
Locations: 401 Quarry Road (Remote Study), Stanford, California
Conditions: Autism Spectrum Disorder, Restricted Behavior, Autism
Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations
Recruiting
The purpose of this study is to determine cross-sectional and longitudinal medical, behavioral, and cognitive differences between PTEN ASD and other groups, as well as to identify cognitive, neural systems, and molecular biomarkers specific to PTEN ASD. In addition, this study will be creating and maintaining a biorepository and linked phenotypic database for PTEN ASD.
Gender:
ALL
Ages:
18 months and above
Trial Updated:
10/24/2024
Locations: Stanford University Medical Center, Stanford, California
Conditions: PTEN, ASD, Autism, Macrocephaly, PTEN Hamartoma Tumor Syndrome
Neuroimaging Predictors of Improvement to Pivotal Response Treatment (PRT) in Young Children with Autism
Recruiting
Autism spectrum disorder (ASD) is a very heterogeneous disorder with limited empirically validated behavioral and biological interventions. The goal of this pilot investigation is to apply a biologically-based approach to identify predictors of treatment response in children with ASD who are receiving Pivotal Response Treatment (PRT), an evidence-based behavioral intervention. Specifically, the investigators propose to identify neuroimaging biomarkers of treatment response to a PRT program (PRT-... Read More
Gender:
ALL
Ages:
Between 2 years and 4 years
Trial Updated:
10/07/2024
Locations: Stanford University, Stanford, California
Conditions: Autism Spectrum Disorder, Autism
A Center Based Study of Pivotal Response Treatment for Preschoolers with Autism
Recruiting
The purpose of this study is to examine the effectiveness of pivotal response training (PRT) in an intensive center-based environment to treat social communication deficits in children with autism spectrum disorder (ASD).
Gender:
ALL
Ages:
Between 2 years and 3 years
Trial Updated:
10/07/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Autism Spectrum Disorder, Autism
A Center Based Early Intervention Program for Preschoolers with Developmental Disorders
Recruiting
The purpose of this study is to examine the effectiveness of a 12-week early intervention program that will include 12 weekly hours in an intensive center-based preschool environment or in the home to treat social communication deficits in children with developmental disorders. The study will include children with developmental disorders, such as Autism Spectrum Disorder, neurogenetic disorders, or intellectual disability.
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
10/07/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Development Disorder, Child, Developmental Disability, Development Delay, Autism Spectrum Disorder
Trial of Center-Based Vs. In-Home Pivotal Response Treatment (PRT) in Autism
Recruiting
The aim of this clinical trial is to compare the efficacy of a 16-week center-based Pivotal Response Treatment (PRT-C) versus home-based Pivotal Response Treatment (PRT-H) in targeting social communication deficits in young children with autism spectrum disorder (ASD) with significant language delay. The two groups will also be compared to a control group that consists of children who are receiving treatment as usual (TAU).
Gender:
ALL
Ages:
Between 2 years and 5 years
Trial Updated:
10/07/2024
Locations: Stanford University School of Medicine, Stanford, California
Conditions: Autism, Autism Spectrum Disorder, ASD