There are currently 1908 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome
NCT04428619
Recruiting
This is a prospective, double-blind, randomized, sham-controlled pilot study evaluating the efficacy of percutaneous electrical nerve field stimulation for the treatment of adult patients with irritable bowel syndrome (IBS).
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/09/2023
Locations: UCLA, Los Angeles, California
Conditions: Irritable Bowel Syndrome, Abdominal Pain, Autonomic Nervous System Imbalance
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Rett Syndrome Registry
NCT05432349
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
All
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
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STIMFIX Trail Lead Anchor System for Dorsal Column Stimulator Trail Leads (SECURE Study)
NCT05651646
Recruiting
This project will investigate the efficacy of a Stimfix Trail lead anchor system (StimfixTM) in patients undergoing dorsal column stimulator trial. In dorsal column stimulator trails, two leads are placed in the epidural space and various frequencies, pulse widths, and amplitudes are run to reduce pain perception. This therapy has been in use for the last 70 years and today there are about 100,000 implants done annually for various pain indications. The process of obtaining the therapy requires... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/07/2022
Locations: Nuvation Pain Group, Los Angeles, California
Conditions: Pain
Register for Updates
Two Year Developmental Follow-up for PREMOD2 Trial (Premature Infants Receiving Milking or Delayed Cord Clamping)
NCT03476980
Recruiting
An extension of the PREMOD2 trial, the PREMOD2 Follow-Up trial will evaluate the neurodevelopmental outcomes at 22-26 months corrected age of preterm children who received UCM or DCC. This prospective multi-national randomized controlled trial (RCT) is a two-arm parallel non-inferiority design of two alternative approaches of treatment.
Gender:
All
Ages:
Between 22 months and 42 months
Trial Updated:
11/22/2022
Locations: LAC+USC Medical Center, Los Angeles, California +1 locations
Conditions: Neurodevelopmental Abnormality
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TruGraf® Long-term Clinical Outcomes Study
NCT04491552
Recruiting
This is a prospective, multi-center, observational study. Subjects will have OmniGraf™ (TruGraf® and TRAC™) testing at study enrollment and thereafter every 3 months. In addition subjects will have OmniGraf™ (TruGraf® and TRAC™) testing at any time there is a clinical suspicion of acute rejection. Data collection for the primary objective extends over a 2-year period.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/10/2022
Locations: Keck Hospital of USC, Los Angeles, California
Conditions: Kidney Transplant Rejection
Register for Updates
Non-invasive Pulmonary Artery Prediction
NCT05622695
Recruiting
Cardiac remote monitoring devices have expanded our ability to track physiological changes used in the diagnosis and management of patients with cardiac disease. Implantable remote monitoring technologies have been shown to predict heart failure events, and guide therapy to reduce heart failure hospitalizations. The CardioMEMs System, the most studied and established remote monitoring system, relies on a pulmonary artery implant for continuous PAP measurement. However, there are no commercially... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
11/09/2022
Locations: PIH Good Samaritan Hospital, Los Angeles, California
Conditions: Heart Failure, Pulmonary Arterial Hypertension
Register for Updates
A Latino MSM Focused Pre-Exposure Prophylaxis Uptake Intervention
NCT05434390
Recruiting
The clinical study will evaluate the feasibility and acceptability of a culturally tailored behavioral intervention to improve uptake of pre-exposure prophylaxis for HIV prevention among at-risk Latino men who have sex with men.
Gender:
Male
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: Bienestar Human Services, Los Angeles, California
Conditions: HIV
Register for Updates
Evaluating the Efficacy of Dual Layer Amniotic Membrane (Artacent®)
NCT04457752
Recruiting
A Randomized Controlled Multicenter Clinical Trial, Evaluating the Efficacy of Dual Layer Amniotic Membrane (Artacent®) and Standard of Care versus Standard of Care alone in the healing Chronic Diabetic Foot Ulcers. Multi-center, open label, randomized controlled trial. Study is estimated to require 12 months from first subject enrolled to last subject visit.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/03/2022
Locations: New Hope Podiatry, Los Angeles, California
Conditions: Chronic Diabetic Foot Ulcers
Register for Updates
Optimizing IV Gentamicin in JEB
NCT04140786
Recruiting
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable and fatal inherited skin disease, is caused by loss-of-function mutations in LAMA3, LAMB3 and LAMC2. These mutations result in diminished laminin 332 and epidermal-dermal adherence. 85% of JEB patients have nonsense mutations in LAMA3, LAMB3, or LAMC2, suggesting that H-JEB is a prime therapeutic target for nonsense suppression therapy. The investigators recently demonstrated in three patients that topical gentamicin created new and... Read More
Gender:
All
Ages:
30 days and above
Trial Updated:
11/01/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Junctional Epidermolysis Bullosa
Register for Updates
Intravenous Gentamicin Therapy for Recessive Dystrophic Epidermolysis Bullosa (RDEB)
NCT03392909
Recruiting
Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable, devastating, inherited skin disease caused by mutations in the COL7A1 gene that encodes for type VII collagen (C7), the major component of anchoring fibrils (AFs), structures that mediate epidermal-dermal adherence. Thirty percent of RDEB patients have nonsense mutations. The investigators recently demonstrated in 5 such patients that intradermal and topical gentamicin induced "read-through" of their nonsense mutations and create... Read More
Gender:
All
Ages:
7 years and above
Trial Updated:
11/01/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Recessive Dystrophic Epidermolysis Bullosa
Register for Updates
Pediatric Cervical Spine Clearance: A Multicenter Prospective Observational Study
NCT05608460
Recruiting
A prospective multicenter observational study, led by Dr. Katie Russell of Intermountain Primary Children's Hospital, that will examine the sensitivity, specificity, negative, and positive predictive values of CT scan and plain films in diagnosing cervical spine injury that requires treatment. This study is funded by the Primary Children's Hospital foundation.
Gender:
All
Ages:
Between 0 years and 17 years
Trial Updated:
11/01/2022
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Cervical Spine Fracture
Register for Updates
Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
NCT05518305
Recruiting
An observational study to determine if individuals with increased platelet FcyRIIa will have a higher risk of ischemic events.
Gender:
All
Ages:
30 years and above
Trial Updated:
10/31/2022
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Stroke, TIA, Ischemic Stroke, Ischemic
Register for Updates