There are currently 1889 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC / Norris Comprehensive Cancer Center, Childrens Hospitla Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of Dietary Composition in Crohn's Disease
NCT04431700
Recruiting
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/04/2023
Locations: UCLA Center for Human Nutrition, 1000 Veteran Ave., Los Angeles, California
Conditions: Inflammatory Bowel Diseases, Crohn Disease
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Aneurysm Genetic Risk in Patients With QIB Changes
NCT05317169
Recruiting
Intracranial aneurysm rupture is a leading cause of hemorrhagic strokes which carry high mortality and disability rates as well as high healthcare costs. Unruptured intracranial aneurysms (UIA) are common in the general population, occurring in 1-2% of individuals. Previous studies have shown that UIA growth and rupture are strongly associated with each other, with growing aneurysms 9-12 times more likely to rupture, and nearly all aneurysms growing prior to rupture. Thanks to advanced medical i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Brain Aneurysm
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KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment
NCT03662126
Recruiting
This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with myelofibrosis (MF) who no longer benefit from treatment with a JAK inhibitor. Inhibition of MDM2 is a novel mechanism of action in MF. This study will be conducted in 2 phases. Phase 2 will determine the KRT-232 recommended dose and dosing schedule; Phase 3 will test KRT-232 vs Best Available Therapy (BAT). Patients in the Phase 3 part of the study will be randomized 2:1 to receive ei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2023
Locations: University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Post-Essential Thrombocythemia MF (Post-ET-MF)
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A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
NCT05588583
Recruiting
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up. The main objective is to follow the progress of these wounds over time from initial visit to each follow-up visit. Participants will be asked to wear Mepilex Up dressing for up to 6 weeks of treatment or until healed, changed at every one-week interval.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Felix Sigal, DPM, Los Angeles, California
Conditions: Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
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Impact of AI on Trainee ADR
NCT05423964
Recruiting
Adenoma detection rate (ADR) is a validated quality metric for colonoscopy with higher ADR correlated with improved colorectal cancer outcomes. Artificial intelligence (AI) can automatically detect polyps on the video monitor which may allow endoscopists in training to improve their ADR. Objective and Purpose of the study: Measure the effect of AI in a prospective, randomized manner to determine its impact on ADR of Gastroenterology trainees.
Gender:
ALL
Ages:
All
Trial Updated:
03/02/2023
Locations: LAC+USC Medical Center, Los Angeles, California
Conditions: Adenoma, Adenoma Colon, Colorectal Cancer
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Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular Disorders
NCT02910180
Recruiting
This study encompasses the maintenance and utilization of a repository of samples from patients with cerebrovascular disease and stroke. The types of tissue taken are blood, cerebrospinal fluid (CSF), tissue, and microdialysis samples. Future analysis of these samples can potentially help investigators to better categorize groups of patients, understand the underlying etiology of these pathologies, identify markers that are associated with favorable or poor outcomes, and track changes that occur... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cerebrovascular Diseases, Ischemic Stroke, Repository
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Allograft Adipose Injectable for Vocal Fold Paralysis
NCT04700566
Recruiting
Renuva is allograft adipose matrix commonly used as a filler in cosmetic procedures. The investigators are studying this material as an injectable in the vocal fold to treat glottic insufficiency. Currently, many products can be used as an injectable in the vocal fold to correct glottic insufficiency such as carbomethycellulose, hyaluronic acid, collagen derivatives and calcium hydroxyapatite amongst others. An ideal injectable would not impair the fibroelastic property of the vocal fold tissu... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/02/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Vocal Fold Palsy
Register for Updates
Rett Syndrome Registry
NCT05432349
Recruiting
The Rett Syndrome Registry is a longitudinal observational study of individuals with MECP2 mutations and a diagnosis of Rett syndrome. Designed together with the IRSF Rett Syndrome Center of Excellence Network medical directors, this study collects data on the signs and symptoms of Rett syndrome as reported by the Rett syndrome experts and by the caregivers of individuals with Rett syndrome. This study will be used to develop consensus based guidelines for the care of your loved ones with Rett s... Read More
Gender:
ALL
Ages:
Between 0 years and 99 years
Trial Updated:
01/09/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Rett Syndrome, Rett Syndrome, Atypical, Genetic Disease, Genetic Diseases, X-Linked, Intellectual Disability, Neurobehavioral Manifestations, Neurologic Manifestations, Neurologic Disorder, Neurodevelopmental Disorders, Nervous System Diseases
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Pediatric Cervical Spine Clearance: A Multicenter Prospective Observational Study
NCT05608460
Recruiting
A prospective multicenter observational study, led by Dr. Katie Russell of Intermountain Primary Children's Hospital, that will examine the sensitivity, specificity, negative, and positive predictive values of CT scan and plain films in diagnosing cervical spine injury that requires treatment. This study is funded by the Primary Children's Hospital foundation.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
11/01/2022
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Cervical Spine Fracture
Register for Updates
Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
NCT01860612
Recruiting
The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects.
Gender:
ALL
Ages:
3 years and above
Trial Updated:
10/21/2022
Locations: Advanced Vision Care, Los Angeles, California +1 locations
Conditions: Full Aniridia, Partial Aniridia
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Deep Brain Stimulation of the Amygdala for Combat Post-Traumatic Stress Disorder
NCT02091843
Recruiting
Posttraumatic stress disorder (PTSD) affects approximately 30 % of American veterans returning from Iraq and Afghanistan. Although the current therapy is effective, a percentage of patients will fail to improve and will develop chronic treatment-resistant PTSD. Patients suffering from PTSD experience intense suffering, lack of productivity and a higher risk of suicide. Unfortunately, combat PTSD has a tendency to be resistant to current treatments. The central goal of this project is to develop... Read More
Gender:
MALE
Ages:
Between 25 years and 70 years
Trial Updated:
10/12/2022
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California
Conditions: Posttraumatic Stress Disorder
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Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
NCT04669548
Recruiting
The Accuryn Registry Study is an open-ended, global, multi-center, retrospective and prospective, single-arm data collection study with an FDA cleared device. The target population are cardiovascular surgery patients. Physiologic data measurements will be collected from enrolled subjects using electronic medical records and data streams via the Accuryn Monitoring System.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
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