There are currently 433 active clinical trials seeking participants for Breast Cancer research studies. The states with the highest number of trials for Breast Cancer participants are California, Ohio, Illinois and Michigan.
Breast Elasticity Imaging During Neoadjuvant Chemotherapy
NCT04824027
Recruiting
For this study, the investigators propose investigation of a new imaging technique, Harmonic Motion Imaging (HMI), and the evaluation of its potential role in prediction of breast cancer response to neoadjuvant chemotherapy (NACT). The investigators hypothesize that changes in HMI parameters will predict response to neoadjuvant systemic therapy in early-stage breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/28/2025
Locations: Columbia University Irving Medical Center/NYP, New York, New York
Conditions: Breast Cancer
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Single Cell Immune and Non-immune Correlates of Response to Neoadjuvant Abemaciclib
NCT04614194
Recruiting
The purpose of this study is to better understand how the immune system plays a role in fighting breast cancer and specifically research if the immune system response against breast cancer can be improved with endocrine therapy and cyclin dependent kinase inhibitor therapy in patients with hormone receptor positive breast cancer. This will be studied by collecting tumor tissue and blood samples before and after 2 weeks of study treatment with commonly used endocrine therapy and cyclin dependent... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/27/2025
Locations: Parkland Hospital, Dallas, Texas +1 locations
Conditions: Breast Cancer
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Opioid Dispensing Device for Post-Operative Pain in Cancer Patients
NCT05585788
Recruiting
This research study will evaluate the use of, and participants experience with, a new device called Addinex that safely stores and dispenses opioid medication. The purpose of this study is to evaluate the use of the Addinex device in cancer patients undergoing cancer-related surgery that require pain control with opioids after the surgery. Participants will be asked to answer questions about their medical history and background, fill out questionnaires, use a mobile application associated with t... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/27/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: Opioid Use, Breast Cancer
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VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients
NCT06878547
Recruiting
Purpose: This study will evaluate how measurements of tissue stiffness, viscosity, and anisotropy using non-invasive ultrasound imaging correlate with breast tumor malignancy and response to chemotherapy. Participants: Up to 200 women with benign or malignant breast tumors for arm 1 and up to 50 women undergoing neoadjuvant chemotherapy in the breast for arm 2 will be recruited. Procedures (methods): The research team will use an ultrasound scanner to acquire non-invasive elastography data fro... Read More
Gender:
FEMALE
Ages:
Between 20 years and 90 years
Trial Updated:
05/27/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Breast Cancer
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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738
Recruiting
This phase 3 clinical trial compares the safety and efficacy of palazestrant (OP-1250) to the standard-of-care options of fulvestrant or an aromatase inhibitor in women and men with breast cancer whose disease has advanced on one endocrine therapy in combination with a CDK4/6 inhibitor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Clinical Trial Site, Tucson, Arizona +173 locations
Conditions: Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, ER Positive Breast Cancer, HER2 Negative Breast Carcinoma
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First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
NCT05768139
Recruiting
Study STX-478-101 is a multipart, open-label, phase 1/2 study evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of STX-478 (LY4064809) in participants with advanced solid tumors with P13Ka mutations. Part 1 will evaluate STX-478 as monotherapy in participants with advanced solid tumors. Part 2 will evaluate STX-478 therapy as combination therapy with fulvestrant in participants with hormone receptor positive (HR+) breast cancer. Part 3 will evaluate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2025
Locations: Angeles Clinic and Research Institute, Los Angeles, California +32 locations
Conditions: Breast Cancer, Solid Tumors, Adult
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Multi-center MRD Registry for Inflammatory Breast Cancer
NCT06966050
Recruiting
To collect data from participants with IBC who may have had MRD testing and may have surgery in the future.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Breast Cancer
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DISCO: A Patient Intervention to Reduce the Financial Burden of Cancer
NCT04766190
Recruiting
The DISCO App is designed to improve, during the interaction, patient active participation and patient-initiated oncologist treatment cost discussions, and, in the short term, patient's treatment cost knowledge, self-efficacy for managing both cost and physician interactions, referrals, perceived financial toxicity (i.e., distress and material hardship); in turn, these will affect longer-term outcomes of financial toxicity and adherence.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Conditions: Financial Toxicity, Cancer, Question Prompt List, Breast Cancer, Prostate Cancer
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Abbreviated MBCT for Depression in Older African American/Black Breast Cancer Survivors
NCT06336538
Recruiting
The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
05/21/2025
Locations: Cleveland Clinic Department of Wellness and Preventive Medicine, Cleveland, Ohio
Conditions: Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Mild Depression, Moderate Depression
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An Acupuncture Study for Breast Cancer Survivors With Joint Pain on Hormonal Therapies
NCT06814977
Recruiting
The purpose of this study is to see whether acupuncture is a practical (feasible) treatment for breast cancer survivors with joint pain on hormonal therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2025
Locations: Memorial Sloan Kettering Cancer Center (All protocol activites), New York, New York +1 locations
Conditions: Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Breast Cancer Stage IIIB, Breast Cancer Stage IIIc, Breast Cancer, Male
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Breast Cancer - Navigate - Prospective Cohort
NCT06271356
Recruiting
The Chrysalis Initiative (TCI) has with its technology partner Eversana/Intouch developed the BC-Navigate website/application to help guide women through care delivery during breast cancer treatment. TCI a nonprofit, breast cancer education and navigation organization is developing methods to address health inequities in cancer care delivery. TCI and its new academic/clinical partner, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, propose to apply TCI's developed pa... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: Northwestern University, Chicago, Illinois
Conditions: Breast Cancer, Quality of Life, Chemotherapy
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Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy
NCT05472792
Recruiting
The aim of this prospective study is to investigate quality of life and oncologic outcomes in low-risk elderly breast cancer patients randomized to adjuvant therapy with accelerated partial breast irradiation (APBI) alone or endocrine therapy alone after lumpectomy. The study population will include women age 65 years and older with low-risk tumor characteristics (tumor size \<2cm, grade 1-2, node-negative). APBI will consist of 5 fractions of radiation therapy delivered every other day to the l... Read More
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
05/19/2025
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Breast Cancer, Quality of Life
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