There are currently 441 active clinical trials seeking participants for Breast Cancer research studies. The states with the highest number of trials for Breast Cancer participants are California, Ohio, Illinois and Michigan.
Understanding and Addressing Disparities in Cancer Therapy Induced Inflammation and Associated Endothelial Dysfunction
NCT05223322
Recruiting
Very little is understood about the off-target vascular mechanisms of anti-cancer drug toxicity and the impact of exercise on these changes. Much of what has been learned about molecular pathways regulating vascular endothelial function has been established by logical expansion of knowledge obtained through experimental studies (e.g., discovery of endothelium-derived relaxing factor/nitric oxide). Within the last 10 years technological advancements of -omics approaches, such as RNA-sequencing an... Read More
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
04/28/2024
Locations: University of Illinois Chicago, Chicago, Illinois +1 locations
Conditions: Breast Cancer
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A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors
NCT05765851
Recruiting
This study will evaluate the safety and efficacy of DS-1103a combination therapy in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2024
Locations: Florida Cancer Specialists, Sarasota, Florida +7 locations
Conditions: Advanced Solid Tumor, Breast Cancer
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Early Detection of Breast Cancer in Women With Suspicious Mammograms
NCT03147430
Recruiting
This is a non-treatment study. It will not involve the use of any investigational drug or device. Potential participants will be enrolled through direct contact with collaborating clinical sites when the patient's annual 3D mammogram report yields a BIRADS rating of 4-5. The clinical Investigators or a member of their staff will conduct consent discussion once a suspicious mammogram report is identified or if a patient is referred for imaging of a suspicious area in the breast. After consenting... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Dorothy G Hoefer Comprehensive Breast Center, Newport News, Virginia +1 locations
Conditions: Breast Cancer
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THRIVE Study: Positive Affect Training for Endocrine Therapy Medication Adherence
NCT06388304
Recruiting
The purpose of this study is to pilot and refine an online behavioral intervention based on Positive Affect Training (PAT) that aims to increase positive emotional attitudes and decrease negative emotional attitudes toward endocrine therapy (ET, i.e., anti-hormonal medication) and to increase positive affect and decrease negative affect more generally, among post-treatment breast cancer survivors who are prescribed ET to prevent recurrence of breast cancer.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
04/24/2024
Locations: University of Colorado Boulder, Boulder, Colorado
Conditions: Breast Cancer, DCIS
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A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors
NCT05989724
Recruiting
This proposed Phase I clinical trial of SON-DP is an FIH, open-label, Phase Ia/Ib dose escalation and expansion study to evaluate the safety, tolerability, PK, and PD of SON-DP in participants with relapsed/refractory/intolerant to standard of care therapies, for advanced/ metastatic solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Banner MD Anderson Cancer Center (BMDACC), Gilbert, Arizona +4 locations
Conditions: Solid Tumor, Breast Cancer, Pancreatic Cancer, Ovarian Cancer, Colorectal Cancer
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Adjuvant Monotherapy With Endocrine Therapy or Accelerated Partial Breast Irradiation Following Lumpectomy for Low Risk Breast Cancer Patients Over 65 (CAMERAN)
NCT05472792
Recruiting
The aim of this prospective study is to investigate quality of life and oncologic outcomes in low-risk elderly breast cancer patients randomized to adjuvant therapy with accelerated partial breast irradiation (APBI) alone or endocrine therapy alone after lumpectomy. The study population will include women age 65 years and older with low-risk tumor characteristics (tumor size \<2cm, grade 1-2, node-negative). APBI will consist of 5 fractions of radiation therapy delivered every other day to the l... Read More
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
04/19/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Breast Cancer, Quality of Life
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Cone Beam Breast CT for Breast Cancer Screening
NCT05036096
Recruiting
Up to one thousand and twenty-eight (1028) patients from screening and diagnostic population will be enrolled and consented to participate in the study to create an enriched data set. These women will be enrolled from annual screening population and diagnostic workup population. The enrolled patient will undergo KBCT scans within 4 weeks of her screening or diagnostic mammography exam and before breast biopsy occurs if biopsy is needed.
Gender:
FEMALE
Ages:
30 years and above
Trial Updated:
04/17/2024
Locations: Port Orange Imaging Center, Port Orange, Florida +3 locations
Conditions: Breast Cancer
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Focused Ultrasound and Gemcitabine in Breast Cancer
NCT04796220
Recruiting
This study will test the use of focused ultrasound ablation, low-dose gemcitabine (a chemotherapy) and the combination of focused ultrasound ablation plus low-dose gemcitabine in patients with early-stage breast cancers. We will be testing the effects of each of these regimens on cells in the immune system. We hypothesize that the combination of focused ultrasound ablation and gemcitabine will decrease myeloid-derived suppressor cells and will increase T cell activity. We also hypothesize that f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Breast Cancer, Breast Neoplasms
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Opioid Dispensing Device for Post-Operative Pain in Cancer Patients Patients
NCT05585788
Recruiting
This research study will evaluate the use of, and participants experience with, a new device called Addinex that safely stores and dispenses opioid medication. The purpose of this study is to evaluate the use of the Addinex device in cancer patients undergoing cancer-related surgery that require pain control with opioids after the surgery. Participants will be asked to answer questions about their medical history and background, fill out questionnaires, use a mobile application associated with t... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/15/2024
Locations: Columbia University Medical Center, New York, New York
Conditions: Opioid Use, Breast Cancer
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Adaptive Symptom Self-Management Immunotherapy Study
NCT05715255
Recruiting
The use of immune checkpoint inhibitors (ICIs), alone or in combination with other cancer treatments is increasing dramatically with immune-related adverse events (irAEs) common (90%) during ICI treatment. Most irAEs are symptomatic and symptom self-management with timely reporting of moderate or severe symptoms to health care providers (HCPs) may reduce irAE severity by early recognition and management, resulting in fewer treatment interruptions and unscheduled health services.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: University of Arizona Cancer Center, Tucson, Arizona +1 locations
Conditions: Breast Cancer, Colon Cancer, Lung Cancer, Skin Cancer, Rectum Cancer
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Evaluate Impact of Exercise Program on Fatigue in Breast Cancer During Chemotherapy
NCT05704842
Recruiting
Assess feasibility of home exercise in reducing fatigue in subjects with breast cancer receiving curative intent chemotherapy. Subjects are randomized to control (no exercise) or intervention group (exercise). The PRO-CTCAE tool and FACIT Fatigue Scale are used to collect patient reported outcomes. Subjects submit data via mobile phone, tablet or computer. Assessments are weekly during chemotherapy (10-20 wks), at end of chemotherapy and 1, 3 and 6 months after chemotherapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/04/2024
Locations: Virtua Health, Voorhees, New Jersey
Conditions: Breast Cancer
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RADIANT: Pre-op Radiation With Abemaciclib and Letrozole
NCT06139107
Recruiting
This phase 1b study investigates the safety and feasibility of combining pre-operative radiation therapy with Cyclin-Dependent Kinase 4 (CDK4/6) inhibitors in participants with hormone receptor positive/HER2 negative (HR+/HER2-) breast cancer. The study aims to assess the benefits of concurrent use of these treatments in a specific participant population, focusing on their safety and tolerability. The hypothesis is that the combination therapy will be well-tolerated, providing valuable insights... Read More
Gender:
FEMALE
Ages:
60 years and above
Trial Updated:
04/01/2024
Locations: Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Conditions: Breast Cancer
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