Chronic Kidney Disease Clinical Trials

A listing of 36 Chronic Kidney Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 36 active clinical trials seeking participants for Chronic Kidney Disease research studies. The states with the highest number of trials for Chronic Kidney Disease participants are California, Texas, Florida and New York.

Featured Trial

Paid Clinical Studies Nationwide

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Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

NCT06278207

Recruiting

This is an observational study, in which data from people in Japan and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their doctors. In observational studies, only observations are made without specified advice or interventions. CKD is a long-term progressive decrease in the kidneys' ability to work properly. In people with T2D, the body does not make enough of a hormone called insulin, or does not use insulin well enough. The resulting high blood sugar levels can cause damage to the kidneys. CKD often occurs together with T2D or as a consequence of T2D. Finerenone works by blocking certain proteins, called mineralocorticoid receptors. By doing this, it may reduce damage to kidneys, heart and blood vessels. Finerenone was recently approved in the US and is now available for doctors to prescribe to people with CKD together with T2D. Consequently, there is a need to collect more information about how finerenone is used, its safety and how well it works under real-world conditions. The main purpose of this study is to collect and describe the characteristics of people with CKD and T2D who are receiving initiate finerenone treatment as prescribed by their doctors. To do this, the researchers will collect general information of the participants such as age or gender and data on kidney function and possible heart problems. The researchers will also collect data on any other disease or medical condition in the participants and on other medications used while taking finerenone. The data will come from a network of commercial electronic health records (EHRs) and national claims data in the United States and in Asia. They cover the period from July 1st, 2021 until March 2024. Only already available data is collected and studied. There are no required visits or tests in this study. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/29/2025

Locations: Many Locations, Multiple Locations, New Jersey +3 locations

Conditions: Chronic Kidney Disease, Type 2 Diabetes Mellitus

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A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria

NCT05196035

Recruiting

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can improve kidney function by helping the renin-angiotensin-aldosterone system (RAAS) to work normally. The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can stop the kidneys from working properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system. The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB. So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function. The main purpose of this study is to learn more about whether finerenone added to either ACEI or ARB can help reduce the amount of protein in the participants' urine more than a placebo. A placebo looks like a treatment but does not have any medicine in it. Participants will also continue to receive their other medications. To see how the treatment work, the doctors will take samples of the participants' urine to measure their protein levels before and during taking treatment and after their last treatment. In addition, blood samples will be taken to monitor kidney function, electrolytes and the amount of finerenone in the blood as well as for other tests. This study will include children with CKD and proteinuria aged from 6 months up to less than 18 years. The participants will take: * either finerenone or the placebo, in addition to * either ACEI or ARB, whichever they take as part of their normal treatment Two visits are required up to 104 days, to check whether a child can take part in the treatment phase of the study. If participants qualify for the treatment phase, they will then undergo treatment for about 180 days. During this time, they will visit the study site at least 7 times. During these visits, the participants will: * have their blood pressure, heart rate, temperature, height and weight measured * have blood and urine samples taken * have physical examinations * have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart) * answer questions about their medication and whether they have any adverse events , or have their parents or guardians answer * answer questions about how they are feeling, or have their parents or guardians answer * answer question about how they like the study medication, or have their parents or guardians answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less

Gender:

ALL

Ages:

Between 6 months and 17 years

Trial Updated:

07/29/2025

Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +162 locations

Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona

Cedars-Sinai Medical Center - Nephrology, Los Angeles, California

Lucille Packard Children's Hospital Stanford - Pediatric Nephrology, Palo Alto, California

Rady Children's Hospital San Diego - Cardiology, San Diego, California

Children's National Medical Center - Nephrology, Washington, District of Columbia

Memorial Transplant Institute - Pediatric Nephrology, Hollywood, Florida

Emory University Hospital/Children's Healthcare of Atlanta - Nephrology, Atlanta, Georgia

University of Iowa Health Care Medical Center - Nephrology, Iowa City, Iowa

The Charlotte R. Bloomberg Children's Center Building - Nephrology, Baltimore, Maryland

Boston Children's Hospital - Main Campus - Nephrology, Boston, Massachusetts

Children's Mercy Hospital Kansas City - Nephrology, Kansas City, Missouri

Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension, Cincinnati, Ohio

Cleveland Clinic | Pediatric Nephrology, Cleveland, Ohio

Nationwide Children's Hospital - Nephrology, Columbus, Ohio

OHSU Doernbecher Children's Hospital - Neurology, Portland, Oregon

Children's Hospital of Philadelphia - Nephrology, Philadelphia, Pennsylvania

Univ of Texas Health Science Center | Nephrology Res Dept, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

Seattle Children's Hospital - Nephrology, Seattle, Washington

Instituto Universitario Hospital Italiano de Buenos Aires | Hospital Italiano de Buenos Aires - Neurology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires

Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires

Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Provincia De San Luis

Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina, Santa Fe, Provincia De Santa Fe

Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Not set

Hospital General de Ninos Pedro de Elizalde | Nephrology Department, Buenos Aires, Not set

The Children's Hospital at Westmead, Westmead, New South Wales

Queensland Children's Hospital, South Brisbane, Queensland

Monash Children's Hospital, Clayton, Victoria

Royal Children's Hospital Melbourne, Parkville, Victoria

Kepler Universitätsklinikum Campus IV, Linz, Oberösterreich

Medizinische Univ Graz | Kinder & Jugendheilkunde, Graz, Steiermark

Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set

AKH Wien | Kinder & Jugendheilkunde, Kindernephrologie, Wien, Not set

Huderf / Ukzkf, Bruxelles - Brussel, Not set

CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set

UZ Gent, Gent, Not set

UZ Gasthuisberg - Pediatric Nephrology, Leuven, Not set

CHC Montlégia - Pediatrics, Liège, Not set

Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais

Hospital Pequeno Principe, Curitiba, Parana

Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirão Preto/SP, Sao Paulo

Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas, São Paulo, Sao Paulo

Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil, Sao Paulo, SP

Instituto da Crianca e do Adolescente, Sao Paulo, Not set

UMHAT Sveti Georgi, Plovdiv, Not set

SHATPD "Prof. Ivan Mitev", Sofia, Not set

MHAT prof. Stoyan Kirkovitch AD, Stara Zagora, Not set

Alberta Children's Hospital - Nephrology Clinic, Calgary, Alberta

McMaster Children's Hospital, Hamilton, Ontario

The Hospital for Sick Children (SickKids), Toronto, Ontario

CHU Sainte-Justine, Montreal, Quebec

Všeobecná fakultní nemocnice v Praze, Praha 2, Not set

Fakultní nemocnice v Motole, Praha 5, Not set

Rigshospitalet - Børn og Unge, Copenhagen, Not set

Odense Universitetshospital - HC Andersen Børne og Ungehospital, Odense C, Not set

Aarhus Universitetshospital - Børn og Unge, Århus N, Not set

Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department, Helsinki, Not set

Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit, Tampere, Not set

Turun yliopistollinen keskussairaala, Turku, Not set

CHU bordeaux - Hopital Pellegrin, BORDEAUX cedex, Not set

CHU de Lyon - Hopital Femme Mère Enfant, Bron, Not set

Hopital Arnaud de Villeneuve CHU Montpellier, Montpellier, Not set

Hopital Robert Debre, Paris, Not set

CHU Strasbourg - Hopital Hautepierre, Strasbourg, Not set

Hôpital des Enfants, TOULOUSE Cedex 9, Not set

Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg

Universitätsklinikum Erlangen, Erlangen, Bayern

Medizinische Hochschule Hannover (MHH), Hannover, Niedersachsen

Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen

Universitätsklinikum Essen, Essen, Nordrhein-Westfalen

Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen

Charité / Pädiatrie, Berlin, Not set

Universitätsklinikum Hamburg Eppendorf (UKE), Hamburg, Not set

Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department, Athens, Not set

Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department, Athens, Not set

University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set

Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit, Ioannina, Not set

Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set

Semmelweis University, Budapest, Not set

Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set

Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set

SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged, Not set

Institute of Kidney Diseases and Research Center Gujarat University of Transplantation Sciences, Ahmedabad, Not set

St. John's National Academy of Health Sciences, Bangalore, Not set

Post Graduate Institute of Medical Education and Research, Chandigarh, Not set

All India Institute of Medical Sciences (AIIMS) - New Delhi, Delhi, Not set

NRS Medical college, Kolkata, Not set

Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set

Wilf Children's Hospital Shaare Zedek Medical Center, Jerusalem, Not set

Health Corporation of Galilee Medical Center, Nahariya, Not set

Clalit Health Services Schneider Children's Medical Center, Petach Tikva, Not set

Dana-Dwek Children's Hospital, Tel Aviv, Not set

Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria, Bologna, Emilia-Romagna

Ospedale Pediatrico Bambino Gesù - Nefrologia, Roma, Lazio

IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene, Genova, Liguria

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene, Milano, Lombardia

Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi, Firenze, Not set

A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica, Torino, Not set

Kyungpook National University Hospital, Daegu, Daegu Gwang''yeogsi

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggido

Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo

Korea University Guro Hospital, Seoul, Seoul Teugbyeolsi

Seoul National University Hospital, Seoul, Seoul Teugbyeolsi

Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set

Klaipeda Children's Hospital, Klaipeda, Not set

Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre, Vilnius, Not set

Hospital Tunku Azizah, Wilayah Persekutuan, Kuala Lumpur

Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan

Hospital Selayang, Shah Alam, Selangor

Sunway Medical Centre, Subang Jaya, Selangor

Hospital Universiti Sains Malaysia, Kelantan, Not set

Sitio Alfredo Chew Wong | Aguascalientes, Mexico, Aguascalientes, Agguascalientes

Instituto Veracruzano en Investigación Clinica SC, Ciudad de Mexico, Distrito Federal

Hospital Infantil de México "Dr. Federico Gómez", México D.F., Distrito Federal

Instituto Nacional de Pediatría, México, D.F., Distrito Federal

Hospital Regional de Alta Especialidad Ixtapaluca, Ixtapaluca, Estado De Mexico

Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia, Nuevo León, Monterrey

Universitair Medisch Centrum Groningen, Groningen, Not set

Universitair Medisch Centrum St. Radboud, Nijmegen, Not set

University Medical Center Utrecht, Utrecht, Not set

Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set

Instytut Centrum Zdrowia Matki Polki, Lodz, Not set

Dzieciecy Szpital Kliniczny im. Jozefa Brudzinskiego, Warszawa, Not set

Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Not set

Uniwersytecki Szpital Kliniczny UM we Wroclawiu, Wroclaw, Not set

Hospital Santa Maria | Centro de Investigacao Clinica, Missing, Lisboa

Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set

Hospital Pediátrico de Coimbra I ULS Coimbra, Coimbra, Not set

Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica, Porto, Not set

Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit, Soweto, Gauteng

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set

Hospital de Sant Joan de Déu, Barcelona, Not set

H Univ. 12 de Octubre | Unidad Pediátrica Inv y EECC (UPIC), Madrid, Not set

Hospital la Paz, Madrid, Not set

Hospital Universitario Regional De Malaga - Nefrologia pediatrica, Málaga, Not set

Hospital Universitario Virgen Del Rocio S.L. - Nefrologia pediatrica, Sevilla, Not set

Skånes Universitetssjukhus Lund - Barnnefroenheten, Lund, Not set

Karolinska University Hospital, Stockholm, Not set

Uppsala University Hospital, Uppsala, Not set

Universitäts-Kinderspital UKBB, Basel, Basel-Stadt

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud

Hopital des Enfants HUG, Geneva, Not set

National Cheng Kung University Hospital, Tainan, TNN

Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch, Guishan, Not set

Kaohsiung Veterans General Hospital, Kaohsiung City, Not set

National Taiwan University Hospital, Taipei, Not set

Chang Gung Memorial Hospital at Linkou, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Cukurova Univ. Tip. Fak. Balcali Hastanesi, Adana, Not set

Hacettepe Universitesi Tip Fakultesi, Ankara, Not set

Baskent Universitesi Tip Fakultesi Hastanesi, Ankara, Not set

Gazi Universitesi Tip Fakultesi, Ankara, Not set

Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, Not set

Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics, Istanbul, Not set

Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi, Istanbul, Not set

Marmara University Medical Faculty | Pediatric Nephrology, Istanbul, Not set

Birmingham Children's Hospital, Birmingham, West Midlands

NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility, Glasgow, Not set

Great Ormond Street Hospital for Children, London, Not set

Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility, Manchester, Not set

Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility, Nottingham, Not set

Conditions: Chronic Kidney Disease, Proteinuria

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A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease

NCT06926660

Recruiting

This study is open to adults with chronic kidney disease (CKD) that is at risk of getting worse. People who have taken a specific type of medication for kidney disease called SGLT2 inhibitor within 1 month before the study or have certain health conditions cannot take part in this study. The purpose of this study is to find out whether a medicine called vicadrostat, used in combination with another medicine called empagliflozin, works in people with chronic kidney disease. In this study, partic... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/28/2025

Locations: Nephrology Consultants, LLC, Huntsville, Alabama +146 locations

Nephrology Consultants, LLC, Huntsville, Alabama

Orange County Clinical Trials, Anaheim, California

North America Research Institute, San Dimas, California

Valiance Clinical Research-Tarzana-68237, Tarzana, California

Amicis Research Center - Valencia, Valencia, California

Focus Clinical Research, West Hills, California

Western Nephrology, Arvada, Arvada, Colorado

Clinical Research of Brandon LLC, Brandon, Florida

Hillcrest Medical Research, DeLand, Florida

Encore Medical Research, Hollywood, Florida

San Marcus Research Clinic, Inc., Miami Lakes, Florida

Finlay Medical Research Corp, Miami, Florida

Total Research Group, LLC, Miami, Florida

West Orange Endocrinology, Ocoee, Florida

Florida Kidney Physicians - Riverview/Brandon, Riverview, Florida

Masters of Clinical Research, Inc, Augusta, Georgia

Velocity Clinical Research, Savannah, Savannah, Georgia

Boise Kidney and Hypertension, PLLC, Boise, Idaho

Research by Design, LLC, Chicago, Illinois

Nephrology Associates of Northern Illinois and Indiana - Oak Brook, Hinsdale, Illinois

Nephrology Associates of Northern Illinois and Indiana - Fort Wayne, Fort Wayne, Indiana

Kansas Nephrology Research Institute, LLC, Wichita, Kansas

LSU Health Sciences Center, New Orleans, Louisiana

Northwest Louisiana Nephrology, Shreveport, Louisiana

Aa Mrc Llc, Flint, Michigan

Michigan Kidney Consultants, Pontiac, Michigan

Sky Clinical Research, Fayette, Mississippi

Midwest Nephrology Associates, Saint Peters, Missouri

Seacoast Kidney and Hypertension Specialists, Portsmouth, New Hampshire

Endocrine Associates of Long Island, Smithtown, New York

Durham Nephrology Associates, Durham, North Carolina

Lucas Research, Inc., Morehead City, North Carolina

Brookview Hills Research Associates LLC, Winston-Salem, North Carolina

Heritage Valley Medical Group, Beaver, Pennsylvania

Southeast Renal Research Institute, Chattanooga, Tennessee

Arlington Nephrology, Arlington, Texas

Endocrine Associates, Houston, Texas

Clinical Advancement Center, PLLC, San Antonio, Texas

Javara Inc.-Stephenville-68996, Stephenville, Texas

Utah Kidney Research Institute, Salt Lake City, Utah

Tidewater Physicians Multispecialty Group, Newport News, Virginia

CEDIC - Centro de Investigacion Clinica, Caba, Not set

Mautalen- Salud e Investigacion, Caba, Not set

Sanatorio Güemes, Capital Federal, Not set

IDIM - Instituto de Diagnostico e Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Not set

Instituto Medico Catamarca - IMEC, Rosario, Not set

CEMEDIC - Centro de Especialidades Medicas, Villa Luro, Not set

John Hunter Hospital, New Lambton Heights, New South Wales

Westmead Hospital, Westmead, New South Wales

Northern Hospital Epping, Epping, Victoria

Royal Perth Hospital, Perth, Western Australia

ULB Hopital Erasme, Bruxelles, Not set

Brussels - UNIV Saint-Luc, Bruxelles, Not set

UZ Leuven, Leuven, Not set

Humani - CHU Charleroi - Chimay, Lodelinsart, Not set

Centro de Pesquisa do Hospital Evangélico de Belo Horizonte, Belo Horizonte, Not set

Chronos Pesquisa Clinica, Brasilia, Not set

CEPIC - Centro Paulista de Investigacao Clinica, Sao Paulo, Not set

Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set

Bluewater Clinical Research, Sarnia, Ontario

Heart Health Institute (Scarborough), Scarborough, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

Toronto General Hospital, Toronto, Ontario

Diex Recherche (Trois-Rivieres), Trois-Rivieres, Quebec

Beijing Tsinghua Changgung Hospital, Beijing, Not set

West China Hospital of Sichuan University, Chengdu, Not set

NanFang Hosptial, Guangzhou, Not set

Zhejiang Province People's Hospital, Hangzhou, Not set

The Second Hospital of Anhui Medical University, Hefei, Not set

Center Hospital of Jinan, Jinan, Not set

The First Affiliated Hospital of Nanchang University, Nanchang, Not set

The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Not set

The First People's Hospital of Nanning, Nanning, Not set

Ningbo Second Hospital, Ningbo, Not set

Second Hospital Affiliated to Shantou Medical University, Shantou, Not set

Shenzhen Second People's Hospital, Shenzhen, Not set

First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Not set

Yibin Second People's Hospital, Yibin, Not set

General Hospital of Ningxia Medical University, Yinchuan, Not set

DIKa centrum s.r.o., Havirov, Not set

MILAN KVAPIL s.r.o., Pribram, Not set

Hospital Slany, Internal Department, Slany, Not set

HOP Bicêtre, Le Kremlin-Bicêtre, Not set

HOP Hôtel-Dieu, Nantes, Not set

HOP Civil, Strasbourg, Not set

Klinikum Bielefeld, Bielefeld, Not set

Internistische Gemeinschaftspraxis in Bünde, Bünde, Not set

Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Not set

Universitätsklinikum Frankfurt, Frankfurt, Not set

DaVita Clinical Research Germany GmbH Geilenkirchen, Geilenkirchen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen, Hannover, Not set

Facharztpraxis für Innere Medizin, Nierenheilkunde und Bluthochdruckkrankheiten, Rotenburg, Not set

Robert Bosch Gesellschaft für medizinische Forschung mbH, Stuttgart, Not set

DKD Helios Klinik Wiesbaden, Wiesbaden, Not set

Ospedale SS Annunziata, Chieti, Not set

Università degli Studi di Perugia, Perugia, Not set

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Not set

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Not set

Kasugai Municipal Hospital, Aichi, Kasugai, Not set

National Hospital Organization Chibahigashi National Hospital, Chiba, Chiba, Not set

Tsuchiura Kyodo General Hospital, Ibaraki, Tsuchiura, Not set

Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Yokohama, Not set

Osaka General Medical Center, Osaka, Osaka, Not set

Ageo Central General Hospital, Saitama, Ageo, Not set

Omihachiman Community Medical Center, Shiga, Omihachiman, Not set

Tokyo Medical University Hachioji Medical Center, Tokyo, Hachioji, Not set

Korea University Ansan Hospital, Ansan-si, Not set

Seoul National University Bundang Hospital, Seongnam, Not set

The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Not set

Hanyang University Medical Center, Seoul, Not set

Yonsei University Wonju Severance Christian Hospital, Wonju-si, Gangwon State, Not set

Hospital Canselor Tuanku Muhriz, Cheras, Not set

Hospital Sultan Idris Shah Serdang, Kajang, Not set

Tuanku Fauziah Hospital, Kangar, Not set

Hospital Kuala Lumpur, Kuala Lumpur, Not set

Amsterdam UMC Locatie AMC, Amsterdam, Not set

Albert SchweitzerZiekenhuis, Dordrecht, Not set

Catharina Ziekenhuis, Eindhoven, Not set

Bethesda Diabetes Research Center, Hoogeveen, Hoogeveen, Not set

Momentum Clinical Research - Kapiti Coast, Kapiti, Wellington Region

Dunedin Hospital, Dunedin, Not set

Waikato Hospital, Hamilton, Not set

Senor Santo Nino Hospital, Camiling, Not set

Norzel Medical and Diagnostic Clinic, Cebu City, Not set

Institute for Studies on Diabetes Foundation Inc., Marikina City, Not set

Philippine Heart Center, Quezon City, Not set

Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk, Bydgoszcz, Not set

Pro Familia Altera Sp. z o.o., Katowice, Not set

Pro Salus Sp. z o.o. sp.k., Lodz, Not set

FDI Clinical Research - Mayagüez, Mayaguez, Not set

Centro de Salud Milladoiro, A Coruña, Not set

C.A.P. Sardenya, Barcelona, Not set

Centro de Salud Cartagena Casco Antiguo, Cartagena, Not set

Eap Osona Sud Alt Congost S.L.P. Cap Centelles, Centelles, Barcelona, Not set

Centro de Salud Naranco, Oviedo, Not set

Centro de Salud de San Juan, Salamanca, Not set

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set

Taichung Veterans General Hospital, Taichung, Not set

National Taiwan University Hospital, Taipei, Not set

Mackay Memorial Hospital, Taipei, Not set

Phramongkutklao Hospital, Bangkok, Not set

Siriraj Hospital, Bangkok, Not set

Maharaj Nakom Chiangmai Hospital, Chiang Mai, Not set

King Chulalongkorn Memorial Hospital, Patumwan, Not set

Queen Elizabeth University Hospital, Glasgow, Not set

Royal Berkshire Hospital, Reading, Not set

Conditions: Chronic Kidney Disease

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A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

NCT05457283

Recruiting

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can help improve kidney function by reducing the activity of the renin-angiotensin-aldosterone system (RAAS). The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can impair the ability of the kidneys to work properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system. The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB. So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function. The main purpose of this study is to learn how safe the treatment is when used of finerenone in addition to an ACEI or ARB in long-term. To see how safe the treatment is, the study team will collect information on medical problems which are also known as "treatment emergent adverse events" (TEAEs). And they will also collect levels of an electrolyte called potassium in the blood by taking blood samples, and measure blood pressure during the study. The secondary purpose of this study is to learn how well long-term use of finerenone can reduce the amount of protein in the participants' urine and benefit kidney function when taken with standard of care. To see how the treatment works, the study team will collect participants' urine samples to assess urinary albumin-to-creatinine ratio (UACR) and urinary protein-to-creatinine ratio (UPCR), which are important assessments for calculating the level of protein in the urine. Researchers will also collect blood samples to analyze serum creatinine and calculate estimated glomerular filtration rate (eGFR). A significant decline in eGFR indicates worsening kidney function. The study will include participants who had previously participated in FIONA study (NCT05196035). The participants will be aged from 1 year up to 18 years. The participants will be in the study for approximately 19 months. They will take study treatment for up to 18 months and will be follow up for 1 month. During this period, at least 12 visits are planned for patients who newly start finerenone, and at least 8 visits for patients who already received finerenone. In the visit, the study team will: * have their blood pressure, heart rate, temperature, height and weight measured * have blood and urine samples taken * have physical examinations * have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart) * answer questions about their medication and whether they have any adverse events, or have their parents or guardian's answer * answer questions about how they are feeling, or have their parents or guardian's answer * answer question about how they like the study medication, or have their parents or guardian's answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less

Gender:

ALL

Ages:

Between 1 year and 18 years

Trial Updated:

07/25/2025

Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +164 locations

Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona

Cedars-Sinai Samuel Oschin Cancer Center, Los Angeles, California