Chronic Kidney Disease Clinical Trials

A listing of 33 Chronic Kidney Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 33 active clinical trials seeking participants for Chronic Kidney Disease research studies. The states with the highest number of trials for Chronic Kidney Disease participants are California, Texas, Florida and New York.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Trial

Chronic Cough Study

Recruiting

Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Allergic Asthma

Learn More

Featured Trial

Studying an Investigational Virus Vaccine

Recruiting

The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.

Conditions:

Healthy

Interested in vaccine studies

All Conditions

Preventative Trials

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Featured Trial

Type 2 Diabetes Clinical Trial

Recruiting

Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.

Conditions:

Type 2 Diabetes

Diabetes Mellitus Type 2 in Obese

Diabetes Type Two

Type 2 Diabetes Mellitus

Diabete Type 2

Learn More

A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

NCT05536804

Recruiting

We are doing this study to learn more about how tirzepatide may help fight chronic kidney disease in people with obesity with or without type 2 diabetes (T2D). The study will last about 56 weeks and include up to 12 visits.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/16/2025

Locations: Valley Clinical Trials, Inc., Northridge, California +27 locations

Valley Clinical Trials, Inc., Northridge, California

University of Colorado Anschutz Medical Campus, Aurora, Colorado

Kidney Associates of Colorado, Denver, Colorado

American Health Network of Indiana, LLC - Avon, Avon, Indiana

American Health Network of Indiana, LLC - Greenfield, Greenfield, Indiana

Indiana University Health University Hospital, Indianapolis, Indiana

American Health Network of Indiana, LLC - Muncie, Muncie, Indiana

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy, Michigan

University of Washington Medical Center - Montlake, Seattle, Washington

Providence Medical Research Center - Spokane, Spokane, Washington

Zentrum für klinische Studien Dr Hanusch Gmbh, Vienna, Wien

Klinik Landstraße, Wien, Not set

Klinik Hietzing, Wien, Not set

LMC Clinical Research Inc. (Barrie), Barrie, Ontario

LMC Clinical Research Inc. (Thornhill), Concord, Ontario

Toronto General Hospital, Toronto, Ontario

Fadia El Boreky Medicine, Waterloo, Ontario

Centre intégré universitaire de santé et de services sociaux de l'Estrie Centre Hospitalier Universitaire -T, Sherbrooke, Quebec

Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland

Health Pharma Professional Research S.A. de C.V:, Ciudad de México, Distrito Federal

Grupo Medico Camino Sc, Mexico City, Distrito Federal

Caimed Investigacion En Salud S.A. de C.V., Mexico City, Distrito Federal

AGNI Research and Assessment S.C., Cuernavaca, Morelos

Investigación Nefrológica, Cuernavaca, Morelos

Centro de Investigación y Gastroenterología, Cuauhtémoc, Not set

Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, Not set

Amsterdam UMC, locatie VUmc, Amsterdam, Noord-Holland

Ziekenhuisgroep Twente, locatie Almelo, Almelo, Overijssel

Conditions: Overweight, Obesity, Chronic Kidney Disease, Type 2 Diabetes, T2D

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A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

NCT06717698

Recruiting

The study evaluates the safety of different doses of a new medicine called NNC0519 0130. It also looks into how the medicine may improve kidney function in participants with chronic kidney disease with or without type 2 diabetes, living with overweight or obesity. The participants will either get NNC0519-0130 (a new medicine), semaglutide (a medicine that doctors can already prescribe), or placebo (a "dummy" substance). Which treatment the participant will get is decided by chance. The study wil... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/15/2025

Locations: N America Res Inst - San Dimas, San Dimas, California +116 locations

N America Res Inst - San Dimas, San Dimas, California

NorCal Endocrinology and Internal Medicine, San Ramon, California

Rocky Mount Reg VA Med-DN, Aurora, Colorado

Northeast Research Institute, Fleming Island, Florida

Encore Medical Research LLC, Hollywood, Florida

Northeast Research Institute, Saint Augustine, Florida

Clinical Research of Cent FL, Winter Haven, Florida

Endeavor Health, Skokie, Illinois

Velocity Clin. Res Valparaiso, Valparaiso, Indiana

Elite Research Center, Flint, Michigan

Albany Medical College, Albany, New York

Carteret Medical Group, Morehead City, North Carolina

Brookview Hills Research Associates, LLC, Winston-Salem, North Carolina

Clinical Advancement Ctr, PLLC, San Antonio, Texas

Tekton Research, San Antonio, Texas

Providence Medical Research Center, Spokane, Washington

Centro Médico CIMEL, Lanus Este, Buenos Aires

Centro de Investigaciones Metabólicas, City of Buenos Aires, Not set

Instituto de Cardiología de Corrientes, Corrientes, Not set

Renalida, Mar Del Plata, Buenos Aires, Not set

Instituto de Investigaciones Clinicas, Mar del Plata, Not set

Gosford Renal Research, Gosford, New South Wales

Heart of Australia, Chelmer, Queensland

Melbourne Renal Research Group, Reservoir, Victoria

Sunshine Hospital, St Albans, Victoria

Quanta Diagnóstico Nuclear / Medicina Nuclear Alto da XV, Curitiba, Parana

Instituto Pró-Renal Brasil, Curitiba, Parana

Centro de Diabetes Curitiba, Curitiba, Parana

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda., Porto Alegre, Rio Grande Do Sul

Hospital do Rim e Hipertensao Fundacao Oswaldo Ramos, Sao Paulo, Not set

Specialized Rehabilitation Hospital Zdrave EAD, Bankya, Not set

"Medical Centre Acad. Iv. Penchev" EOOD, Sofia, Not set

USHATE "Akad. Ivan Penchev" Second Clinic of Endocrinology, Sofia, Not set

"UMHAT "Sveta Anna" Sofia", Sofia, Not set

UMHAT Sofiamed, Sofia, Not set

UMHAT Sveta Marina EAD, Varna, Not set

MUDr. Petr Buček s.r.o., Frýdek Místek, Not set

CTC Hodonin s.r.o., Hodonin, Not set

FNKV-Internal Clinic-Nephrology, Praha 10, Not set

IKEM Klinika nefrologie, Praha 4, Not set

Fledip s.r.o., Praha 6, Not set

DiaVize s.r.o., Praha, Not set

Internist Care s.r.o., Smiřice, Not set

Nemocnice Český Krumlov, a.s., Český Krumlov, Not set

Endolife Specialty Hospitals, Guntur, Andhra Pradesh

MS Ramaiah, Bengaluru, Karnataka

Government Medical College, Kozhikode, Kozhikode, Kerala

SMS Medical College & Hospital, Jaipur, Rajasthan

Diabetes, Thyroid and Endocrine Centre, Jaipur, Rajasthan

Diabetes Research Center, Hyderabad, Hyderabad, Telangana

Nizams Institute of Medical Science, Hyderabad, Telangana

Ospedale San Salvatore, Dipartimento Medico ASL1 Abruzzo, UOC Diabetologia, L'Aquila, Abbruzzo

Università degli studi G. D'Annunzio Chieti Pescara - CAST, Chieti, Abruzzo

A.O.U. Bologna_ Policlinico S.Orsola Malpighi, Bologna, BO

Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Not set

Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Not set

Azienda Ospedaliera Luigi Sacco, Milano, Not set

Azienda Ospedaliero Universitaria Pisana Ospedale Cisanello, Pisa, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Not set

TOSAKI Clinic for Diabetes and Endocrinology_Diabetes and Endocrinology, Aichi, Not set

Naka Kinen Clinic, Ibaraki, Not set

Fujisawa City Hospital_Kidney internal medicine, Kanagawa, Not set

Higashijujo Sakai Diabetes Clinic_Internal Medicine, Kita-ku, Tokyo, Not set

Koshigaya Municipal Hospital_Internal medicine, Saitama, Not set

Hanyu General Hospital_Internal Medicine, Saitama, Not set

Shinden Higashi Clinic, Sendai-shi, Miyagi, Not set

Omihachiman Community Medical Center_Nephrology, Siga, Not set

Kato Clinic of Internal Medicine, Tokyo, Not set

Pusan National University Hospital, Busan, Not set

National Health Insurance Corporation Ilsan Hospital, Goyang, Not set

Hallym University Sacred Heart Hospital, Gyeonggi-Do, Not set

Hanyang University GURI Hospital, Gyeonggi-do, Not set

Seoul Saint Mary's Hospital, Seoul, Not set

Korea University Guro Hospital, Seoul, Not set

Hospital Miri, Sarawak, Miri

Hospital Raja Permaisuri Bainun Ipoh, Ipoh, Perak

Hospital Sibu, Sibu, Sarawak

University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur

Hospital Universiti Sains Malaysia, Kota Bharu, Kelantan, Not set

Prince Court Medical Centre, Kuala Lumpur, Not set

Hospital Melaka, Melaka, Not set

Hospital Pulau Pinang, Pulau Pinang, Not set

Hospital Sungai Buloh, Sungai Buloh, Not set

Kardio Life, Włocławek, Kujawsko-pomorskie

Terpa Sp. z o.o. Sp. k., Lublin, Lubelskie Voivodeship

Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie, Rzeszow, Podkarpackie

Uniwersytecki Szpital Kliniczny w Bialymstoku, Białystok, Not set

Uniwersyteckie Centrum Kliniczne SUM w Katowicach, Katowice, Not set

Zanamed Medical Clinic Sp. z o.o., Lublin, Not set

Wojewodzki Szpital Specjalistyczny w Olsztynie, Olsztyn, Not set

Uniwersytecki Szpital Kliniczny Nr 2 PUM W Szczecinie, Szczecin, Not set

Szpitale Tczewskie S.A., Tczew, Not set

PANSTWOWY INSTYTUT MEDYCZNY MSWiA, Warszawa, Not set

Centrum Medyczne Oporow, Wroclaw, Not set

SP ZOZ Centralny Szpital Kliniczny Uniwerystetu Medycznego w Łodzi, Łódź, Not set

Nowy Szpital Sp. z o.o., Świecie, Not set

Hospital Clinic i Provincial, Barcelona, Not set

Hospital Reina Sofia, Córdoba, Not set

Hospital Universitario de Getafe, Getafe, Not set

Hospital de Bellvitge, Hospitalet de Llobregat, Not set

Fundacion Jiménez Díaz, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Clínica Nuevas Tecnologías en Diabetes y Endocrinología, Sevilla, Not set

Hospital Universitario Doctor Peset, Valencia, Not set

Erciyes Universitesi Tip Fakultesi, Kayseri, Melikgazi

T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan, Adana, Not set

Hacettepe Universitesi Tip Fakultesi Nefroloji Bilim Dali, Ankara, Not set

Ankara Sehir Hastanesi Dahiliye Klinigi, Ankara, Not set

Gaziantep Universitesi Tip Fakultesi Hastanesi, Gaziantep, Not set

T.C SB Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Not set

Ege Universitesi Tip Fakultesi Hastanesi, Izmir, Not set

Kocaeli University Nephrology Department, Kocaeli, Not set

Conditions: Chronic Kidney Disease

Learn More ›

ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE

NCT05746559

Recruiting

The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent cardiac surgery with CPB.

Gender:

ALL

Ages:

Between 18 years and 90 years

Trial Updated:

04/14/2025

Locations: Research Site, Tucson, Arizona +209 locations

Research Site, Tucson, Arizona

Research Site, Orange, California

Research Site, San Francisco, California

Research Site, Stanford, California

Research Site, Aurora, Colorado

Research Site, Washington, District of Columbia

Research Site, Gainesville, Florida

Research Site, Orlando, Florida

Research Site, Weston, Florida

Research Site, Atlanta, Georgia

Research Site, Chicago, Illinois

Research Site, Fort Wayne, Indiana

Research Site, Indianapolis, Indiana

Research Site, Louisville, Kentucky

Research Site, Boston, Massachusetts

Research Site, Springfield, Massachusetts

Research Site, Detroit, Michigan

Research Site, Kansas City, Missouri

Research Site, Saint Louis, Missouri

Research Site, Lincoln, Nebraska

Research Site, Haddon Heights, New Jersey

Research Site, Rochester, New York

Research Site, Valhalla, New York

Research Site, Durham, North Carolina

Research Site, Winston-Salem, North Carolina

Research Site, Fargo, North Dakota

Research Site, Cleveland, Ohio

Research Site, Columbus, Ohio

Research Site, Philadelphia, Pennsylvania

Research Site, Charleston, South Carolina

Research Site, Dallas, Texas

Research Site, Houston, Texas

Research Site, Plano, Texas

Research Site, San Antonio, Texas

Research Site, Salt Lake City, Utah

Research Site, Charlottesville, Virginia

Research Site, Richmond, Virginia

Research Site, Seattle, Washington

Research Site, Tacoma, Washington

Research Site, Wisconsin Rapids, Wisconsin

Research Site, Buenos Aires, Not set

Research Site, Caba, Not set

Research Site, Ciudad Autónoma de Bs. As., Not set

Research Site, Cordoba, Not set

Research Site, Corrientes, Not set

Research Site, Córdoba, Not set

Research Site, San Luis, Not set

Research Site, Santa Fé, Not set

Research Site, Adelaide, Not set

Research Site, Brisbane, Not set

Research Site, Canberra, Not set

Research Site, Heidelberg, Not set

Research Site, Monash, Not set

Research Site, Murdoch, Not set

Research Site, Southport, Not set

Research Site, Vienna, Not set

Research Site, Belo Horizonte, Not set

Research Site, Brasillia, Not set

Research Site, Campinas, Not set

Research Site, Fortaleza, Not set

Research Site, Porto Alegre, Not set

Research Site, Recife, Not set

Research Site, Ribeirão Preto, Not set

Research Site, Rio de Janeiro, Not set

Research Site, S.J. Do Rio Preto, Not set

Research Site, Salvador, Not set

Research Site, Sao Paulo, Not set

Research Site, São Paulo, Not set

Research Site, Edmonton, Alberta

Research Site, Winnipeg, Manitoba

Research Site, Saint John, New Brunswick

Research Site, Hamilton, Ontario

Research Site, Kingston, Ontario

Research Site, Toronto, Ontario

Research Site, Montreal, Quebec

Research Site, Montréal, Quebec

Research Site, Beijing, Not set

Research Site, Fuzhou, Not set

Research Site, Gaozhou, Not set

Research Site, Guangzhou, Not set

Research Site, Hangzhou, Not set

Research Site, Huai'an, Not set

Research Site, Ningbo, Not set

Research Site, Shanghai, Not set

Research Site, Shenzhen, Not set

Research Site, Tianjin, Not set

Research Site, Wuhan, Not set

Research Site, Xi'an, Not set

Research Site, Zhengzhou City, Not set

Research Site, Zhengzhou, Not set

Research Site, Zunyi, Not set

Research Site, Bordeaux Cedex, Not set

Research Site, Dijon Cedex, Not set

Research Site, Montpellier, Not set

Research Site, Toulouse Cedex 3, Not set

Research Site, Dresden, Not set

Research Site, Essen, Not set

Research Site, Frankfurt am Main, Not set

Research Site, Giessen, Not set

Research Site, Halle (Saale), Not set

Research Site, Heidelberg, Not set

Research Site, Jena, Not set

Research Site, Muenster, Not set

Research Site, München, Not set

Research Site, Stuttgart, Not set

Research Site, Trier, Not set

Research Site, Hong Kong, Not set

Research Site, Bangalore, Not set

Research Site, Delhi, Not set

Research Site, Gurgaon, Not set

Research Site, Hyderabad, Not set

Research Site, Mysuru, Not set

Research Site, Secunderabad, Not set

Research Site, Haifa, Not set

Research Site, Petah Tikva, Not set

Research Site, Ramat Gan, Not set

Research Site, Bari, Not set

Research Site, Firenze, Not set

Research Site, Milano, Not set

Research Site, Milan, Not set

Research Site, Napoli, Not set

Research Site, Bunkyo-ku, Not set

Research Site, Chuo-ku, Not set

Research Site, Kamakura-shi, Not set

Research Site, Kawasaki-shi, Not set

Research Site, Minato-ku, Not set

Research Site, Okayama-shi, Not set

Research Site, Sagamihara-shi, Not set

Research Site, Suginami, Not set

Research Site, Urayasu, Not set

Research Site, Anyang-si, Not set

Research Site, Bucheon-si, Not set

Research Site, Busan, Not set

Research Site, Daegu, Not set

Research Site, Seongnam-si, Not set

Research Site, Seoul, Not set

Research Site, Groningen, Not set

Research Site, Maastricht, Not set

Research Site, Rotterdam, Not set

Research Site, Białystok, Not set

Research Site, Bielsko-Biała, Not set

Research Site, Chrzanów, Not set

Research Site, Grudziądz, Not set

Research Site, Katowice, Not set

Research Site, Kraków, Not set

Research Site, Poznań, Not set

Research Site, Szczecin, Not set

Research Site, Tychy, Not set

Research Site, Warszawa, Not set

Research Site, Łódź, Not set

Research Site, Coimbra, Not set

Research Site, Lisboa, Not set

Research Site, A Coruna, Not set

Research Site, Barcelona, Not set

Research Site, Córdoba, Not set

Research Site, Madrid, Not set

Research Site, Majadahonda, Not set

Research Site, Navarra, Not set

Research Site, Santander, Not set

Research Site, Sevilla, Not set

Research Site, Valencia, Not set

Research Site, Valladolid, Not set

Research Site, Hualien City, Not set

Research Site, Kaohsiung, Not set

Research Site, New Taipei, Not set

Research Site, Taichung, Not set

Research Site, Tainan City, Not set

Research Site, Taipei City, Not set

Research Site, Taipei, Not set

Research Site, Ankara, Not set

Research Site, Antalya, Not set

Research Site, Istanbul, Not set

Research Site, Menemen/Izmir, Not set

Research Site, Odunpazarı, Not set

Research Site, Cambridge, Not set

Research Site, Clydebank, Not set

Research Site, Edinburgh, Not set

Research Site, London, Not set

Research Site, Newcastle upon Tyne, Not set

Conditions: Chronic Kidney Disease, CKD, Cardiac Disease, Cardiopulmonary Bypass

Learn More ›

An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

NCT06278207

Recruiting

This is an observational study, in which data from people in Japan and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their doctors. In observational studies, only observations are made without specified advice or interventions. CKD is a long-term progressive decrease in the kidneys' ability to work properly. In people with T2D, the body does not make enough of a hormone called insulin, or does not use insulin well enough. The resulting high blood sugar levels can cause damage to the kidneys. CKD often occurs together with T2D or as a consequence of T2D. Finerenone works by blocking certain proteins, called mineralocorticoid receptors. By doing this, it may reduce damage to kidneys, heart and blood vessels. Finerenone was recently approved in the US and is now available for doctors to prescribe to people with CKD together with T2D. Consequently, there is a need to collect more information about how finerenone is used, its safety and how well it works under real-world conditions. The main purpose of this study is to collect and describe the characteristics of people with CKD and T2D who are receiving initiate finerenone treatment as prescribed by their doctors. To do this, the researchers will collect general information of the participants such as age or gender and data on kidney function and possible heart problems. The researchers will also collect data on any other disease or medical condition in the participants and on other medications used while taking finerenone. The data will come from a network of commercial electronic health records (EHRs) and national claims data in the United States and in Japan. They cover the period from July 1st, 2021 until March 2024. Only already available data is collected and studied. There are no required visits or tests in this study. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/11/2025

Locations: Many Locations, Multiple Locations, New Jersey +2 locations

Conditions: Chronic Kidney Disease, Type 2 Diabetes Mellitus

Learn More ›

A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria

NCT05196035

Recruiting

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can improve kidney function by helping the renin-angiotensin-aldosterone system (RAAS) to work normally. The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can stop the kidneys from working properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system. The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB. So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function. The main purpose of this study is to learn more about whether finerenone added to either ACEI or ARB can help reduce the amount of protein in the participants' urine more than a placebo. A placebo looks like a treatment but does not have any medicine in it. Participants will also continue to receive their other medications. To see how the treatment work, the doctors will take samples of the participants' urine to measure their protein levels before and during taking treatment and after their last treatment. In addition, blood samples will be taken to monitor kidney function, electrolytes and the amount of finerenone in the blood as well as for other tests. This study will include children with CKD and proteinuria aged from 6 months up to less than 18 years. The participants will take: * either finerenone or the placebo, in addition to * either ACEI or ARB, whichever they take as part of their normal treatment Two visits are required up to 104 days, to check whether a child can take part in the treatment phase of the study. If participants qualify for the treatment phase, they will then undergo treatment for about 180 days. During this time, they will visit the study site at least 7 times. During these visits, the participants will: * have their blood pressure, heart rate, temperature, height and weight measured * have blood and urine samples taken * have physical examinations * have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart) * answer questions about their medication and whether they have any adverse events , or have their parents or guardians answer * answer questions about how they are feeling, or have their parents or guardians answer * answer question about how they like the study medication, or have their parents or guardians answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less

Gender:

ALL

Ages:

Between 6 months and 17 years

Trial Updated:

04/11/2025

Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +155 locations

Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona

University of California San Diego (UCSD), La Jolla, California

Lucille Packard Children's Hospital Stanford - Pediatric Nephrology, Palo Alto, California

Children's National Medical Center - Nephrology, Washington, District of Columbia

South Broward Hosp. District dba Memorial Healthcare System, Hollywood, Florida

Emory University Hospital/Children's Healthcare of Atlanta - Nephrology, Atlanta, Georgia

University of Iowa, Iowa City, Iowa

The Charlotte R. Bloomberg Children's Center Building - Nephrology, Baltimore, Maryland

Boston Children's Hospital - Main Campus - Nephrology, Boston, Massachusetts

Children's Mercy Hospital Kansas City - Nephrology, Kansas City, Missouri

Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension, Cincinnati, Ohio

Cleveland Clinic | Pediatric Nephrology, Cleveland, Ohio

Nationwide Children's Hospital - Nephrology, Columbus, Ohio

Oregon Health and Science Univ | Doernbecher Childrens Hosp, Portland, Oregon

Children's Hospital of Philadelphia - Nephrology, Philadelphia, Pennsylvania

Univ of Texas Health Science Center | Nephrology Res Dept, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

Seattle Children's Hospital, Seattle, Washington

Instituto Universitario Hospital Italiano de Buenos Aires | Hospital Italiano de Buenos Aires - Neurology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires

Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Ciudad Autonoma de Buenos Aire, Ciudad Auton. De Buenos Aires

Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Provincia De San Luis

Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina, Santa Fe, Provincia De Santa Fe

Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Not set

Hospital General de Ninos Pedro de Elizalde | Nephrology Department, Buenos Aires, Not set

The Children's Hospital at Westmead, Westmead, New South Wales

Queensland Children's Hospital, South Brisbane, Queensland

Monash Children's Hospital, Clayton, Victoria

Royal Children's Hospital Melbourne, Parkville, Victoria

Kepler Universitätsklinikum Campus IV, Linz, Oberösterreich

Medizinische Univ Graz | Kinder & Jugendheilkunde, Graz, Steiermark

Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set

AKH Wien | Kinder & Jugendheilkunde, Kindernephrologie, Wien, Not set

Huderf / Ukzkf, Bruxelles - Brussel, Not set

CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set

UZ Gent, Gent, Not set

UZ Gasthuisberg - Pediatric Nephrology, Leuven, Not set

CHC Montlégia - Pediatrics, Liège, Not set

Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais

Hospital Pequeno Principe, Curitiba, Parana

Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirão Preto/SP, Sao Paulo

Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas, São Paulo, Sao Paulo

Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil, Sao Paulo, SP

Instituto da Crianca e do Adolescente, Sao Paulo, Not set

UMHAT Sveti Georgi, Plovdiv, Not set

SHATPD "Prof. Ivan Mitev", Sofia, Not set

MHAT prof. Stoyan Kirkovitch AD, Stara Zagora, Not set

Alberta Children's Hospital - Nephrology Clinic, Calgary, Alberta

McMaster Children's Hospital, Hamilton, Ontario

The Hospital for Sick Children (SickKids), Toronto, Ontario

CHU Sainte-Justine, Montreal, Quebec

Všeobecná fakultní nemocnice v Praze, Praha 2, Not set

Fakultni nemocnice v Motole, Praha 5, Not set

Rigshospitalet - Børn og Unge, Copenhagen, Not set

Odense Universitetshospital - HC Andersen Børne og Ungehospital, Odense C, Not set

Aarhus Universitetshospital - Børn og Unge, Århus N, Not set

Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department, Helsinki, Not set

Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit, Tampere, Not set

Turun yliopistollinen keskussairaala, Turku, Not set

Hôpital Pellegrin - Bordeaux, BORDEAUX cedex, Not set

CHU de Lyon - Hopital Femme Mère Enfant, Bron, Not set

Hopital Arnaud de Villeneuve CHU Montpellier, Montpellier, Not set

Hopital Robert Debre, Paris, Not set

CHU Strasbourg - Hopital Hautepierre, Strasbourg, Not set

Hôpital des Enfants, TOULOUSE Cedex 9, Not set

Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg

Universitätsklinikum Erlangen, Erlangen, Bayern

Medizinische Hochschule Hannover (MHH), Hannover, Niedersachsen

Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen

Universitätsklinikum Essen, Essen, Nordrhein-Westfalen

Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen

Charité / Pädiatrie, Berlin, Not set

Universitätsklinikum Hamburg Eppendorf (UKE), Hamburg, Not set

Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department, Athens, Not set

Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department, Athens, Not set

University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set

Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit, Ioannina, Not set

Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set

Semmelweis University, Budapest, Not set

Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set

Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set

SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged, Not set

St. John's National Academy of Health Sciences, Bangalore, Not set

All India Institute of Medical Sciences (AIIMS) - New Delhi, Delhi, Not set

NRS Medical college, Kolkata, Not set

Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set

Wilf Children's Hospital Shaare Zedek Medical Center, Jerusalem, Not set

Health Corporation of Galilee Medical Center, Nahariya, Not set

Clalit Health Services Schneider Children's Medical Center, Petach Tikva, Not set

Dana-Dwek Children's Hospital, Tel Aviv, Not set

Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria, Bologna, Emilia-Romagna

Ospedale Pediatrico Bambino Gesù - Nefrologia, Roma, Lazio

IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene, Genova, Liguria

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene, Milano, Lombardia

Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi, Firenze, Not set

A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica, Torino, Not set

Kyungpook National University Hospital, Daegu, Daegu Gwang''yeogsi

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggido

Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo

Korea University Guro Hospital, Seoul, Seoul Teugbyeolsi

Seoul National University Hospital, Seoul, Seoul Teugbyeolsi

Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set

Klaipeda Children's Hospital, Klaipeda, Not set

Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre, Vilnius, Not set

Hospital Tunku Azizah, Wilayah Persekutuan, Kuala Lumpur

Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan

Hospital Selayang, Shah Alam, Selangor

Sunway Medical Centre, Subang Jaya, Selangor

Hospital Universiti Sains Malaysia, Kelantan, Not set

Sitio Alfredo Chew Wong | Aguascalientes, Mexico, Aguascalientes, Agguascalientes

Instituto Veracruzano en Investigación Clinica SC, Ciudad de Mexico, Distrito Federal

Hospital Infantil de México "Dr. Federico Gómez", México D.F., Distrito Federal

Instituto Nacional de Pediatría, México, D.F., Distrito Federal

Hospital Regional de Alta Especialidad Ixtapaluca, Ixtapaluca, Estado De Mexico

Universitair Medisch Centrum Groningen, Groningen, Not set

Universitair Medisch Centrum St. Radboud, Nijmegen, Not set

University Medical Center Utrecht, Utrecht, Not set

Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set

Instytut Centrum Zdrowia Matki Polki, Lodz, Not set

Dzieciecy Szpital Kliniczny im. Jozefa Brudzinskiego, Warszawa, Not set

Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Not set

Uniwersytecki Szpital Kliniczny UM we Wroclawiu, Wroclaw, Not set

Hospital Santa Maria | Centro de Investigacao Clinica, Missing, Lisboa

Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set

Hospital Pediátrico de Coimbra I ULS Coimbra, Coimbra, Not set

Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica, Porto, Not set

Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit, Soweto, Gauteng

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set

Hospital de Sant Joan de Déu, Barcelona, Not set

H Univ. 12 de Octubre | Unidad Pediátrica Inv y EECC (UPIC), Madrid, Not set

Hospital la Paz, Madrid, Not set

University Hospital of Malaga | Unidad de Gestion Clinica de Pediatria, Málaga, Not set

Virgen del Rocio University Hospital | Pediatric Nephrology Unit, Sevilla, Not set

Skånes Universitetssjukhus Lund - Barnnefroenheten, Lund, Not set

Karolinska University Hospital, Stockholm, Not set

Uppsala University Hospital, Uppsala, Not set

Universitäts-Kinderspital UKBB, Basel, Basel-Stadt

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud

Hopital des Enfants HUG, Geneva, Not set

Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch, Guishan, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Cukurova Univ. Tip. Fak. Balcali Hastanesi, Adana, Not set

Hacettepe Universitesi Tip Fakultesi, Ankara, Not set

Baskent Universitesi Tip Fakultesi Hastanesi, Ankara, Not set

Gazi Universitesi Tip Fakultesi, Ankara, Not set

Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, Not set

Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics, Istanbul, Not set

Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi, Istanbul, Not set

Marmara University Medical Faculty | Pediatric Nephrology, Istanbul, Not set

Birmingham Children's Hospital, Birmingham, West Midlands

Royal Hospital for Children, Glasgow, Not set

Great Ormond Street Hospital for Children, London, Not set

Royal Manchester Children's Hospital, Manchester, Not set

Queens Medical Centre, Nottingham, Not set

Conditions: Chronic Kidney Disease, Proteinuria

Learn More ›

A Study to Learn About How Well BAY3283142 Works and Its Safety in Participants With Chronic Kidney Disease

NCT06522997

Recruiting

Researchers are looking for a better way to treat people who have chronic kidney disease (CKD), CKD is a condition in which the kidneys' ability to work properly gradually decreases over time. A common sign of decreasing kidney function is the body losing too much of a protein called albumin in the urine. This condition is known as albuminuria. This can lead to a faster decline in kidney function. People who have high blood pressure and diabetes are more likely to have CKD and are at a higher risk of complications related to it. BAY3283142 is a new drug that is being developed to treat people with CKD. It works by activating a protein that helps relax blood vessels and is thought to have beneficial effects in CKD. In this study, researchers want to learn about how well different doses of BAY3283142 work when taken with standard treatment for CKD in reducing albumin in the urine of participants with CKD. They will compare the results of the change in the urine albumin-creatinine ratio (UACR) after 16 weeks for BAY3283142 with a placebo. A placebo looks like the study drug but does not have any medicine in it. During the study, participants will take either of the following drugs: * BAY3283142: Participants will take BAY3283142 as tablets by mouth. * Placebo: Participants will take it in the same way as BAY3283142. Participants will continue taking the available standard treatment for CKD and other conditions they may have (for example, heart conditions and diabetes). At the start of this study, the researchers will check the medical history and current medications of the participants. They will also perform a complete health check-up of all the participants. Researchers will take urine and blood samples from the participants at different time points to measure UACR and eGFR. Participants will be divided equally into different groups. Only 1 group will receive placebo and the other groups will receive BAY3283142. Participants will take their assigned treatment for 16 weeks. No one will know who receives which drug or dose of BAY3283142 during the study. Participants will be in this study for around 23 weeks. This includes the time for screening before the start of treatment and follow-up with participants after treatment. People can join this study if they: * are 18 years of age or older and have been diagnosed with CKD * have poor kidney function according to the eGFR test * have abnormally high levels of albumin in the urine according to the UACR test * have been taking certain drugs at a stable dose for management of high blood pressure, diabetes, kidney disease, etc. for at least 4 weeks before the start of the study People cannot join this study if they: * have low blood pressure * have had a stroke or a heart attack, or were hospitalized because of heart failure in the 3 months before the start of the study * have a serious liver disease * have a kidney disease for which they need to take drugs that control the immune system The detailed requirements will be discussed between the study doctors and people considering joining this study. Participants may or may not get the expected benefits of treatment with BAY3283142, but they will receive thorough medical check-ups during this study. These can help to improve individual treatment in the future and to identify unknown medical risks. Some participants may experience medical problems during this study including pain and discomfort when blood samples are taken. Researchers will closely monitor and manage any medical problems the participants may have. They will not include people who should not take BAY3283142 due to known safety concerns. The findings from this study may contribute to developing a new treatment option for people with CKD who have excess albumin in the urine. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/10/2025

Locations: Nephrology Consultants, LLC, Huntsville, Alabama +169 locations

Nephrology Consultants, LLC, Huntsville, Alabama

Balboa Research SMO+ - Chula Vista - West, Chula Vista, California

Balboa Research SMO+ - La Mesa, La Mesa, California

California Kidney Specialists - San Dimas, San Dimas, California

Yale University School of Medicine, New Haven, Connecticut

Nova Clinical Research | Brandenton, FL, Bradenton, Florida

Renstar Medical Research, Ocala, Florida

Elixia Central Florida, Orlando, Florida

Florida Institue for Clinical Research, Orlando, Florida

Southeastern Clinical Research Institute, LLC, Augusta, Georgia

Research by Design, LLC | Chicago, IL, Chicago, Illinois

Nephrology Associates of Northern Illinois and Indiana - Hinsdale, Hinsdale, Illinois

Triad Internal Medicine, Asheboro, North Carolina

Eastern Nephrology Associates - New Bern, New Bern, North Carolina

Brookview Hills Research Associates, LLC, Winston-Salem, North Carolina

Knoxville Kidney Center, PLLC, Knoxville, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Renal Disease Research Institute | Landry, Dallas, Texas

Southwest Houston Research, Ltd., Houston, Texas

Clinical Advancement Center, PLLC, San Antonio, Texas

DaVita Clinical Research | Westover Hills, San Antonio, TX, San Antonio, Texas

DaVita Clinical Research | North Houston, TX, Shenandoah, Texas

Utah Kidney Research Institute | Salt Lake City, UT, S. Salt Lake, Utah

Peninsula Kidney Associates, Hampton, Virginia

Manassas Clinical Research Center, Manassas, Virginia

Salem VA Medical Center - Cardiology, Salem, Virginia

Mendez Center For Clinical Research | Woodbridge, VA, Woodbridge, Virginia

Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aire, Buenos Aires

Centro de Investigaciones Medicas Temperley | Buenos Aires, Argentina, Temperley, Buenos Aires

CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina, Caba, Ciudad Auton. De Buenos Aires

Centro de Especialidades Medicas (Cemedic) | Cardiology Department, Villa Luro, Ciudad Auton. De Buenos Aires

Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC), Buenos Aires, Not set

Centro Privado San Vicente Diabetes, Córdoba, Not set

Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Not set

Fundacion Centro de Salud e Investigaciones Medicas | Santa Rosa, Argentina, Santa Rosa, Not set

Epicura / Nephrology, Baudour, Not set

UZ Gent / Nephrology, Gent, Not set

Jan Yperman Ziekenhuis / Nephrology, Ieper, Not set

UZ Brussel Nephrology, Jette, Not set

UZ Leuven / Nephrology, Leuven, Not set

AZ Delta / Nephrology, Roeselare, Not set

The First Affiliated Hospital of Xiamen University, Xiamen, Fujian

The First Affiliated Hospital of Guangzhou University of TCM, Guangzhou, Guangdong

The Third Xiangya Hospital of Central South University, Changsha, Hunan

Huai'an First People's Hospital, Nanjing Medical University, Huai'An, Jiangsu

The Second Affiliated Hospital of Nanjing Medical university, Nanjing, Jiangsu

The Second Hospital of Jilin University, Changchun, Jilin

Shandong Provincial Hospital, Jinan, Shandong

Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang

Capital Medical University (CMU) - Beijing Anzhen Hospital (BAH), Beijing, Not set

Peking University People's Hospital, Beijing, Not set

Sichuan University - West China Hospital, Chengdu, Not set

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (SAMSPH), Chengdu, Not set

The First People's Hospital - Foshan, Foshan, Not set

Southern Medical University - Nanfang Hospital (Southern Hospital), Guangzhou, Not set

Jiangsu Province Hospital of Traditional Chinese Medicine (TCM), Nanjing, Not set

Renji Hospital Shanghai JiaoTong University of Medicine, Shanghai, Not set

Huadong Hospital, Affiliated to Fudan University, Shanghai, Not set

Shanxi Bethune Hospital, Taiyuan, Not set

General Hospital of Athens LAIKO, Athens, Not set

University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set

University of Thessaly - General University Hospital of Larissa (UHL), Larissa, Not set

University Hospital of Ioannina (UHI), Nisos Ioanninon, Not set

University General Hospital of Patras | Nephrology Clinic, Patra, Not set

Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set

General Hospital of Thessaloniki Papageorgiou, Thessaloniki, Not set

Hellenic Republic Ministry of Health & Welfare - General Hospital of Thessaloniki (George Papanikolaou), Thessaloniki, Not set

Mavani Research Center, Ahmedabad, Gujarat

Marengo Asia Hospital, Gurugram, Gurugram, Haryana

Life Care Clinic (LifeCare Clinic & Research Centre (LCRC)), Bangalore, Not set

The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital), Calcutta, Not set

Madras Diabetes Research Foundation, Chennai, Not set

All India Institute of Medical Sciences (AIIMS) - New Delhi, New Delhi, Not set

Max Super Speciality Hospital, Saket (West Block), (A unit of Max Healthcare Institute Limited), New Delhi, Not set

Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto, Bologna, Emilia-Romagna

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Nefrologia, Brescia, Lombardia

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia, Dialisi e Trapianti di Rene, Milano, Lombardia

ASST Papa Giovanni XXIII | Ospedale di Bergamo - SC Malattie Endocrine-Diabetologia, Bergamo, Not set

Azienda Ospedaliera Universitaria Gaetano Martino Messina - Nefrologia e Dialisi, Messina, Not set

Azienda Ospedaliero Universitaria di Modena_Policlinico - Nefrologia, Dialisi e Trapianto di Rene, Modena, Not set

Istituti Clinici Scientifici Maugeri S.p.A._Pavia - Nefrologia, Pavia, Not set

Kasugai Municipal Hospital, Kasugai, Aichi

Chubu Rosai Hospital, Nagoya, Aichi

Juntendo University Urayasu Hospital, Urayasu, Chiba

Saiseikai Matsuyama Hospital, Matsuyama, Ehime

Fukui Prefectural Hospital, Fukui-shi, Fukui

Kokura Memorial Hospital, Kitakyushu, Fukuoka

Hirohata Naika Clinic, Kitakyushu, Fukuoka

Steel Memorial Yawata Hospital, Kitakyusyu, Fukuoka

Jiyugaoka Yamada Internal Medicine Clinic, Obihiro, Hokkaido

Naka Kinen Clinic, Naka-shi, Ibaraki

JA Toride Medical Center, Toride, Ibaraki

Komatsu Municipal Hospital, Komatsu City, Ishikawa

Shonan Kamakura General Hospital, Kamakura, Kanagawa

Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Kanagawa

Yokohama City University Hospital, Yokohama, Kanagawa

Katta General Hospital, Shiroishi, Miyagi

Rinku General Medical Center, Izumisano, Osaka

Hamamatsu University Hospital, Hamamatsu, Shizuoka

NTT Medical Center Tokyo, Shinagawa-ku, Tokyo

University of Yamanashi Hospital, Chuo, Yamanashi

Japanese Red Cross Fukuoka Hospital, Fukuoka, Not set

Ehime Prefectural Central Hospital, Matsuyama, Not set

Nara Prefecture General Medical Center, Nara, Not set

Osaka General Medical Center, Osaka, Not set

Japanese Red Cross Saitama Hospital, Saitama, Not set

Yonsei University Wonju Christian Hospital, Wonju, Gang''weondo

Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggido

Korea University Anam Hospital, Seoungbuk-gu, Seoul

Korea University Ansan Hospital, Gyeonggi-do, Not set

Samsung Medical Center, Seoul, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Asan Medical Center, Seoul, Not set

Hospital Garcia de Orta | Research Department, Almada, Lisboa

Centro Hospitalar de Lisboa Ocidental | Clinical Research Department, Carnaxide, Lisboa

Hospital de Vila Franca de Xira | Centro de Desenvolvimento e Investigacao, Vila Franca de Xira, Lisboa

Hospital Pedro Hispano | Clinical Research Center, Matosinhos, Porto

Centro Hospitalar do Medio Tejo | Unidade de Torres Novas - Nephrology Department, Torres Novas, Santarém

Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set

CHUC- Hospitais da Universidade de Coimbra - Nephrology Department, Coimbra, Not set

Centro Hospitalar Universitario de Lisboa Central | Hospital Curry Cabral - Nephrology Department, Lisboa, Not set

Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica, Lisboa, Not set

Associacao Protectora dos Diabeticos de Portugal | Departamento de Ensaios Clinicos, Lisbon, Not set

National University Hospital Medical Centre, Singapore, Not set

Singapore General Hospital, Singapore, Not set

National Heart Centre Singapore, Singapore, Not set

Tan Tock Seng Hospital, Singapore, Not set

SingHealth Polyclinics - Pasir Ris, Singapore, Not set

Changi General Hospital, Singapore, Not set

Khoo Teck Puat Hospital, Singapore, Not set

Nemocnica Akademika L. Derera - UNB, Nefrologicka ambulancia, Bratislava, Not set

DIABEDA s.r.o., Bratislava, Not set

MEDISPEKTRUM s.r.o., Bratislava, Not set

B. Braun Avitum Nefrologicka Ambulancia | Galanta, Slovakia, Galanta, Not set

NephroCare | FMC-dialyzacne sluzby s.r.o. - Kosice, Kosice, Not set

Univerzitna nemocnica Martin, Martin, Not set

Biodial | Puchov, Slovakia, Puchov, Not set

DIAB s.r.o, Roznava, Not set

B. Braun Avium Nefrologicka ambulancia | Sala, Slovakia, Sala, Not set

Gerencia de Gestion Integrada A Coruna | Department of Endocrinology and Nutrition, A Coruna, A Coruña

Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Nephrology Department, L'Hospitalet de Llobregat, Barcelona

Hospital Clinico Universitario de Valencia | Nephrology Department, Missing, Valencia

Hospital Quironsalud Barcelona | Internal Medicine Department, Barcelona, Not set

Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial, Ferrol, Not set

Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna, Madrid, Not set

Hospital Universitario Fundacion Jimenez Diaz | Nephrology and Hypertension Department, Madrid, Not set

Hospital Universitario Nuestra Senora de Valme | Internal Medicine Department, Sevilla, Not set

Hospital Universitario Doctor Peset | Nephrology Department, Valencia, Not set

La Fe University and Polytechnic Hospital | Nephrology Department, Valencia, Not set

Sahlgrenska Universitetssjukhuset - Njurkliniken, Gothenburg, Not set

Universitetssjukhuset i Linköping, LInköping, Not set

ProbareE Stockholm, Stockholm, Not set

Center For Diabetes, Academic Specialist Center, Stockholm, Not set

Akademiska sjukhuset (Uppsala University Hospital) - Njurkliniken, Uppsala, Not set

Changhua Christian Hospital, Changhua, Not set

Chang Gung Memorial Hospital Kaohsiung, Kaohsiung, Not set

Far Eastern Memorial Hospital, New Taipei, Not set

Chi-Mei Medical Center, Liouyine, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Salford Royal Hospital, Salford, Manchester

Queen Elizabeth Hospital, Birmingham, Not set

Cardiff and Vale University Health Board - University Hospital of Wales (UHW), Cardiff, Not set

Epsom and St Helier University Hospitals NHS Trust | St Helier Hospital - Clinical Trials Unit, Carshalton, Not set

Hull University Teaching Hospitals NHS Trust | Hull Royal Infirmary - Academic Renal Research Department, Hull, Not set

Royal London Hospital, London, Not set

Royal Free London NHS Foundation Trust | Royal Free Hospital - Cancer Services, London, Not set

King's College Hospital NHS Foundation Trust | King's College Hospital - Renal Research Department, London, Not set

Manchester Royal Infirmary, Manchester, Not set

Lakeside Healthcare Research Department, Northamptonshire, Not set

Conditions: Chronic Kidney Disease

Learn More ›

A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease.

NCT06675175

Recruiting

The purpose of this study is to evaluate the safety, tolerability and the pharmacodynamics (PD) of AZD4144 following oral administration in participants with atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD).

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

04/09/2025

Locations: Research Site, Glendale, California +18 locations

Conditions: Chronic Kidney Disease, Atherosclerotic Cardiovascular Disease

Learn More ›

A Natural History Study of Metabolic Sizing in Health and Disease

NCT05398783

Recruiting

Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate. But metabolism varies among people with similar body sizes. Scientists now believe the old formulas for estimating metabolic rates may not work well for all people. Researchers want to find more accurate ways to measure a person s metabolism. Objective: This natural history study will examine the relations... Read More

Gender:

ALL

Ages:

Between 2 years and 99 years

Trial Updated:

03/25/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Metabolic Disorders, Cancer, Chronic Kidney Disease, Diabetes, Normal Physiology

Learn More ›

A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

NCT05457283

Recruiting

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can help improve kidney function by reducing the activity of the renin-angiotensin-aldosterone system (RAAS). The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can impair the ability of the kidneys to work properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system. The study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB. So, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function. The main purpose of this study is to learn how safe the treatment is when used of finerenone in addition to an ACEI or ARB in long-term. To see how safe the treatment is, the study team will collect information on medical problems which are also known as "treatment emergent adverse events" (TEAEs). And they will also collect levels of an electrolyte called potassium in the blood by taking blood samples, and measure blood pressure during the study. The secondary purpose of this study is to learn how well long-term use of finerenone can reduce the amount of protein in the participants' urine and benefit kidney function when taken with standard of care. To see how the treatment works, the study team will collect participants' urine samples to assess urinary albumin-to-creatinine ratio (UACR) and urinary protein-to-creatinine ratio (UPCR), which are important assessments for calculating the level of protein in the urine. Researchers will also collect blood samples to analyze serum creatinine and calculate estimated glomerular filtration rate (eGFR). A significant decline in eGFR indicates worsening kidney function. The study will include participants who had previously participated in FIONA study (NCT05196035). The participants will be aged from 1 year up to 18 years. The participants will be in the study for approximately 19 months. They will take study treatment for up to 18 months and will be follow up for 1 month. During this period, at least 12 visits are planned for patients who newly start finerenone, and at least 8 visits for patients who already received finerenone. In the visit, the study team will: * have their blood pressure, heart rate, temperature, height and weight measured * have blood and urine samples taken * have physical examinations * have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart) * answer questions about their medication and whether they have any adverse events, or have their parents or guardian's answer * answer questions about how they are feeling, or have their parents or guardian's answer * answer question about how they like the study medication, or have their parents or guardian's answer The doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments. The doctors will check the participants' health about 30 days after the participants take their last treatment. Read Less

Gender:

ALL

Ages:

Between 1 year and 18 years

Trial Updated:

03/25/2025

Locations: Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona +153 locations

Phoenix Children's Hospital | Main - Transplant Department, Phoenix, Arizona

University of California San Diego (UCSD), La Jolla, California

Lucille Packard Children's Hospital Stanford - Pediatric Nephrology, Palo Alto, California

Children's National Medical Center - Nephrology, Washington, District of Columbia

South Broward Hosp. District dba Memorial Healthcare System, Hollywood, Florida

Emory University Hospital/Children's Healthcare of Atlanta - Nephrology, Atlanta, Georgia

University of Iowa, Iowa City, Iowa

The Charlotte R. Bloomberg Children's Center Building - Nephrology, Baltimore, Maryland

Boston Children's Hospital - Main Campus - Nephrology, Boston, Massachusetts

Children's Mercy Hospital Kansas City - Nephrology, Kansas City, Missouri

Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension, Cincinnati, Ohio

Cleveland Clinic | Pediatric Nephrology, Cleveland, Ohio

Oregon Health and Science Univ | Doernbecher Childrens Hosp, Portland, Oregon

Children's Hospital of Philadelphia - Nephrology, Philadelphia, Pennsylvania

Univ of Texas Health Science Center | Nephrology Res Dept, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

Seattle Children's Hospital, Seattle, Washington

Hospital de Niños Sor María Ludovica, La Plata, Buenos Aires

Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Ciudad Autónoma de Buenos Aire, Ciudad Auton. De Buenos Aires

Centro de Rehabilitacion Cardiovascular | San Luis, Argentina, San Luis, Provincia De San Luis

Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina, Santa Fe, Provincia De Santa Fe

Hospital Italiano de Buenos Aires, Buenos Aires, Not set

Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Not set

Hospital General de Ninos Pedro de Elizalde | Nephrology Department, Ciudad Autonoma de Buenos Aire, Not set

Many Locations, Multiple Locations, Not set

Queensland Children's Hospital, South Brisbane, Queensland

Monash Children's Hospital, Clayton, Victoria

Royal Children's Hospital Melbourne, Parkville, Victoria

Kepler Universitätsklinikum Campus IV, Linz, Oberösterreich

Medizinische Universität Graz, Graz, Steiermark

Many Locations, Multiple Locations, Not set

Uniklinikum Salzburg - Landeskrankenhaus, Salzburg, Not set

Universitätsklinikum AKH Wien, Wien, Not set

Huderf / Ukzkf, Bruxelles - Brussel, Not set

CU Saint-Luc/UZ St-Luc, Bruxelles - Brussel, Not set

UZ Gent, Gent, Not set

UZ Gasthuisberg - Pediatric Nephrology, Leuven, Not set

CHC Montlégia - Pediatrics, Liège, Not set

Many Locations, Multiple Locations, Not set

Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais

Hospital Pequeno Principe, Curitiba, Parana

Hosp Clínicas Facult. Med. de Ribeirão Preto / USP, Ribeirão Preto/SP, Sao Paulo

Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas, São Paulo, Sao Paulo

Instituto da Crianca e do Adolescente, Sao Paulo, Not set

Alberta Children's Hospital - Nephrology Clinic, Calgary, Alberta

The Hospital for Sick Children (SickKids), Toronto, Ontario

CHU Sainte-Justine, Montreal, Quebec

Many Locations, Multiple Locations, Not set

Všeobecná fakultní nemocnice v Praze, Praha 2, Not set

Fakultni nemocnice v Motole, Praha 5, Not set

Rigshospitalet - Børn og Unge, Copenhagen, Not set

Many Locations, Multiple Locations, Not set

Odense Universitetshospital - HC Andersen Børne og Ungehospital, Odense C, Not set

Aarhus Universitetshospital - Børn og Unge, Århus N, Not set

Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department, Helsinki, Not set

Many Locations, Multiple Locations, Not set

Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit, Tampere, Not set

Turun yliopistollinen keskussairaala, Turku, Not set

Hôpital Pellegrin - Bordeaux, BORDEAUX cedex, Not set

CHU de Lyon - Hopital Femme Mère Enfant, Bron, Not set

Hopital Arnaud de Villeneuve CHU Montpellier, Montpellier, Not set

Many Locations, Multiple Locations, Not set

Hopital Robert Debre, Paris, Not set

CHU STRASBOURG - Hôpital de Hautepierre, Strasbourg, Not set

Hôpital des Enfants, TOULOUSE Cedex 9, Not set

Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg

Universitätsklinikum Erlangen, Erlangen, Bayern

Medizinische Hochschule Hannover (MHH) | Zentrum Innere Medizin | Klinik fuer Kardiologie und Angiologie, Hannover, Niedersachsen

Kindernierenzentrum Bonn, Bonn, Nordrhein-Westfalen

Universitätsklinikum Essen, Essen, Nordrhein-Westfalen

Universitaetsklinikum Muenster, Münster, Nordrhein-Westfalen

Charité / Pädiatrie, Berlin, Not set

Universitätsklinikum Hamburg Eppendorf (UKE), Hamburg, Not set

Many Locations, Multiple Locations, Not set

Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department, Athens, Not set

Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department, Athens, Not set

University General Hospital of Heraklion - Department of Paediatrics, Heraklion, Not set

Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit, Ioannina, Not set

Many Locations, Multiple Locations, Not set

Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit', Thessaloniki, Not set

Semmelweis University, Budapest, Not set

Debreceni Egyetem Klinikai Kozpont, Debrecen, Not set

Many Locations, Multiple Locations, Not set

Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs, Not set

SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont, Szeged, Not set

All India Institute of Medical Sciences (AIIMS) - New Delhi, Delhi, Not set

NRS Medical college, Kolkata, Not set

Clalit Health | Soroka Medical Center - Internal Medicine Department, Beer Sheva, Not set

Wilf Children's Hospital Shaare Zedek Medical Center, Jerusalem, Not set

Many Locations, Multiple Locations, Not set

Health Corporation of Galilee Medical Center, Nahariya, Not set

Clalit Health Services Schneider Children's Medical Center, Petach Tikva, Not set

Dana-Dwek Children's Hospital, Tel Aviv, Not set

Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria, Bologna, Emilia-Romagna

Ospedale Pediatrico Bambino Gesù - Nefrologia, Roma, Lazio

IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene, Genova, Liguria

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene, Milano, Lombardia

Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi, Firenze, Not set

Many Locations, Multiple Locations, Not set

A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica, Torino, Not set

Kyungpook National University Hospital, Daegu, Daegu Gwang''yeogsi

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggido

Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnamdo

Seoul National University Hospital, Seoul, Seoul Teugbyeolsi

Many Locations, Multiple Locations, Not set

Korea University Guro Hospital, Seoul, Not set

Hospital of LT University of Health Sciences Kaunas Clinics, Kaunas, Not set

Klaipeda Children's Hospital, Klaipeda, Not set

Many Locations, Multiple Locations, Not set

Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre, Vilnius, Not set

Universitair Medisch Centrum Groningen, Groningen, Not set

Many Locations, Multiple Locations, Not set

University Medical Center Utrecht, Utrecht, Not set

Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa, Bialystok, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set

Instytut Centrum Zdrowia Matki Polki, Lodz, Not set

Many Locations, Multiple Locations, Not set

Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa, Not set

Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu, Wroclaw, Not set

Hospital Santa Maria | Centro de Investigacao Clinica, Missing, Lisboa

Centro Clinico Academico Braga | Braga, Portugal, Braga, Not set

Hospital Pediátrico de Coimbra I ULS Coimbra, Coimbra, Not set

Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica, Porto, Not set

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, Not set

Hospital de Sant Joan de Déu, Barcelona, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital la Paz, Madrid, Not set

Many Locations, Multiple Locations, Not set

University Hospital of Malaga | Unidad de Gestion Clinica de Pediatria, Málaga, Not set

Virgen del Rocio University Hospital | Pediatric Nephrology Unit, Sevilla, Not set

Skåne University Hospital, Lund, Not set

Many Locations, Multiple Locations, Not set

Karolinska University Hospital, Stockholm, Not set

Uppsala University Hospital, Uppsala, Not set

Universitäts-Kinderspital UKBB, Basel, Basel-Stadt

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud

Hopital des Enfants HUG, Geneva, Not set

Many Locations, Multiple Locations, Not set

Hacettepe Universitesi Tip Fakultesi, Ankara, Not set

Baskent Universitesi Tip Fakultesi Hastanesi, Ankara, Not set

Gazi Universitesi Tip Fakultesi, Ankara, Not set

Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, Not set

Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics, Istanbul, Not set

Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi, Istanbul, Not set

Marmara University Medical Faculty | Pediatric Nephrology, Istanbul, Not set

Many Locations, Multiple Locations, Not set

Royal Hospital for Children, Glasgow, Stratchclyde

Birmingham Children's Hospital, Birmingham, West Midlands

Great Ormond Street Hospital for Children, London, Not set

Royal Manchester Children's Hospital, Manchester, Not set

Many Locations, Multiple Locations, Not set

Queens Medical Centre, Nottingham, Not set

Conditions: Chronic Kidney Disease, Proteinuria, Children

Learn More ›

A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting

NCT05348733

Recruiting

This is an observational study in people with chronic kidney disease (CKD) and type 2 diabetes (T2D) who will be receiving finerenone. Kidneys filter extra water and waste out of the blood and make urine. CKD is a long-term, progressive, decrease in the kidneys' ability to filter the blood properly. In people with T2D, the body does not make enough of a hormone called insulin, or does not use insulin well enough, resulting in high blood sugar levels that can cause damage to the kidneys. As a result, CKD can occur as a complication of T2D. Finerenone works by blocking certain proteins, called mineralocorticoid receptors. An increased stimulation of these proteins is thought to damage the kidneys and the heart. By lowering their stimulation, finerenone reduces the risk of kidney disease progressively getting worse. Finerenone is available and approved for doctors to prescribe to people with CKD and T2D. Since it has only recently become available for these patients, there is a need for more information about the use of finerenone in the real-world setting. The main purpose of the study is to learn more about treatment patterns in people with CKD and T2D who just started or will start finerenone treatment as decided and prescribed by their doctor as part of their routine medical care. To answer this question, the researchers will collect data on: * Clinical characteristics (e.g., history of CKD and T2D, blood pressure, heart health) of the participants * Reasons for starting finerenone * Reasons for stopping finerenone early * How long participants have been taking finerenone (planned by their doctor compared to actual time it was taken) * Dosing of finerenone * Other medications used while taking finerenone The researchers will also collect data on medical problems (called adverse events) that the participants may have during the study. All adverse events are collected, even if they might not be related to the study treatment. Hyperkalemia, a medical term used to describe a potassium level in the blood that is higher than normal, is of special interest when finerenone is combined with some medications commonly taken to control blood pressure. Researchers want to know how often higher potassium levels occur, and when it leads to: * Stopping finerenone treatment too early * Dialysis (a medical procedure to filter the blood of extra water and waste) * Care in a hospital All data will come from medical records or from interviews study doctors will have with the participants during visits that take place during routine medical care. Participants in the US will be invited to provide voluntary blood and urine samples that could be analyzed later to better understand possible changes in protein or nucleic acid levels over time. Each participant will be in the study for 12 months. This time participating in the study may be shorter if their finerenone treatment is stopped early or the study comes to an end as planned in September 2027. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/24/2025

Locations: Nephrology Consultants LLC, Huntsville, Alabama +67 locations

Nephrology Consultants LLC, Huntsville, Alabama

AKDHC Medical Research Servies LLC, Phoenix, Arizona

Harrisburg Family Medical Center, Harrisburg, Arkansas

Kidney Disease Medical Group, Glendale, California

Renal Consultants Medical Group, Granada Hills, California

Keck School of Medicine of University of Southern California, Los Angeles, California

UCSF Nephrology Clinic, San Francisco, California

University of Central Florida College of Medicine, Orlando, Florida

Gulf View Medical, Port Charlotte, Florida

Hanson Clinical Research Center, Port Charlotte, Florida

Metabolic Research Institute, West Palm Beach, Florida

Ellipsis Group, Alpharetta, Georgia

Augusta University, Augusta, Georgia

Coastal Medical Research, Brunswick, Georgia

Caritas Medical Center, Stockbridge, Georgia

Herman Clinical Research LLC, Suwanee, Georgia

Laurie Tom, MD, Honolulu, Hawaii

Pacific Diabetes & Endocrine Center, Honolulu, Hawaii

Cook County Health, Chicago, Illinois

Jesse Brown VA Medical Center, Chicago, Illinois

Medico, Chicago, Illinois

Nephrology Associates Northern Illinois and Indiana, Hinsdale, Illinois

Kidney and Hypertension Center of Wabash Valley LLC, Terre Haute, Indiana

University of Iowa Preventive Intervention Clinic, Iowa City, Iowa

Northwest Louisiana Nephrology, Shreveport, Louisiana

Ochsner Medical Foundation, Slidell, Louisiana

University of Maryland Midtown Professionals Group Healthcare, Baltimore, Maryland

NECCR Primacare Research, LLC, Fall River, Massachusetts

Healthy Heart Cardiology, Grand Rapids, Michigan

Care Access Research - Minneapolis, Minneapolis, Minnesota

Jackson Medical Mall University Home Dialysis Clinic, Jackson, Mississippi

Nephrology and Hypertension Associates, Tupelo, Mississippi

Renown Regional Medical Center, Reno, Nevada

The EnLyv Clinics, Edison, New Jersey

Gaffney Health Services, Charlotte, North Carolina

Bland Clinic, Greensboro, North Carolina

Ardmore Medical Research, Winston-Salem, North Carolina

Panoramic Health, Providence, Rhode Island

DarSalud Care / LifeDOC Research, Memphis, Tennessee

Academy of Diabetes Thyroid and Endocrine, El Paso, Texas

AA Medical Research Center, Flint, Texas

Prolato Clinical Research, Houston, Texas

Clinical Research Stategies Inc, Houston, Texas

RGV Endocrine Center, McAllen, Texas

Dallas Renal Group, Plano, Texas

Tranquil Clinical Research, Webster, Texas

University of Utah, Salt Lake City, Utah

Washington Nephrology Associates, Alexandria, Virginia

MultiCare Endocrinology Specialists Tacoma, Tacoma, Washington

Many Locations, Multiple Locations, Not set

Conditions: Chronic Kidney Disease, Type 2 Diabetes Mellitus

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A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo

NCT06131372

Recruiting

This study will look if CagriSema can lower kidney damage in people with chronic kidney disease (CKD), type 2 diabetes (T2D) and overweight or obesity. CagriSema is a new investigational medicine. CagriSema cannot yet be prescribed by doctors. The study will compare CagriSema to the 2 medicines semaglutide and cagrilintide, when they are taken alone. It will also compare CagriSema to a "dummy" medicine (also called placebo) without any active ingredient. Participant will either get CagriSema, se... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/18/2025

Locations: John Muir Physicians Network, Concord, California +139 locations

John Muir Physicians Network, Concord, California

Valley Research, Fresno, California

Desert Oasis Hlthcr Med Group, Palm Springs, California

North America Research Institute, San Dimas, California

NorCal Endocrinology and Internal Medicine, San Ramon, California

Northeast Research Institute, Fleming Island, Florida

Life Spring Research, Miami, Florida

Florida Hospital Translational Research Institute, Orlando, Florida

Velocity Clin. Res Valparaiso, Valparaiso, Indiana

Elite Research Center, Flint, Michigan

Univ. of Nebraska Medical Center_Omaha, Omaha, Nebraska

Albany Medical College, Albany, New York

NYU Langone Neph Associates, Mineola, New York

New York University School of Medicine, New York, New York

Southgate Medical Group, LLP, West Seneca, New York

Carteret Medical Group, Morehead City, North Carolina

Eastern Nephr Assoc, PLLC, New Bern, North Carolina

Brookview Hills Research Associates, LLC, Winston-Salem, North Carolina

Ohio- Advanced Medical Research, Maumee, Ohio

Heritage Valley Medical Group Inc, Beaver, Pennsylvania

Main Street Physician's Care, Little River, South Carolina

Osvaldo A. Brusco MD PA, Corpus Christi, Texas

Southwest Houston Research Ltd, Houston, Texas

Clinical Advancement Ctr, PLLC, San Antonio, Texas

Clinical Inv Spec, Inc.Kenosha, Kenosha, Wisconsin

Mautalen Salud e investigación, Caba, Buenos Aires

Centro de Investigaciones Médicas Clínica de Fracturas y Or, Mar del Plata, Buenos Aires

Fundación CESIM, Santa Rosa, La Pampa

Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli, Buenos Aires, Not set

Centro Médico Privado San Vicente Diabetes, Córdoba, Not set

Instituto Pró-Renal Brasil, Curitiba, Parana

Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda., Porto Alegre, Rio Grande Do Sul

CPCLIN - Centro de Pesquisas Clínicas, São Paulo, Sao Paulo

Hospital do Rim e Hipertensao Fundacao Oswaldo Ramos, Sao Paulo, Not set

Centricity Research Calgary, Calgary, Alberta

Centricity Research Brampton, Brampton, Ontario

Centricity Research Vaughn, Concord, Ontario

Centricity Research Etobicoke, Etobicoke, Ontario

Hamilton Medical Rsrch Grp, Hamilton, Ontario

Bluewater Clin Res Group Inc, Sarnia, Ontario

UHN-Toronto General Hospital, Toronto, Ontario

Ctr de rech Clin de Laval, Laval, Quebec

Centre Medical Acadie, Montreal, Quebec

Groupe Sos Sante-Hopital Le Creusot-Hotel Dieu-1, Le Creusot, Not set

Gie Groupe Hospitalier Paris Saint-Joseph/Vinci, Paris Cedex 14, Not set

Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set

Centre Hospitalier Universitaire Reims-Hopital Maison Blanche, Reims cedex, Not set

Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-1, Saint Herblain, Not set

Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1, Toulouse Cedex 9, Not set

Centre de Recherche Clinique Portes Du Sud, Venissieux, Not set

Periphery University Hospital of Heraklion, Heraklion / Crete, Crete

Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter, Athens, Not set

General hospital of Athens 'G.Gennimatas', Athens, Not set

Iatriko Athinon 'Palaiou Falirou', Athens, Not set

"Laiko" General Hospital of Athens, Athens, Not set

Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter, Athens, Not set

General hospital of Athens 'G.Gennimatas', Athens, Not set

General Hospital of Lamia, Lamia, Not set

Univ Gen Hospital Larisa, Endocrinology & Metabolic Disease, Larissa, Not set

General University Hospital of Patras,Nephrology clinic, Patra, Not set

General University Hospital of Patras,Nephrology clinic, Rio, Patra, Not set

General Hospital of Thessaloniki 'G. Gennimatas, Thessaloniki, Not set

"Ippokrateio" G.H. of Thessaloniki, Thessaloniki, Not set

General Hospital of Thessaloniki "Ippokrateio", Thessaloniki, Not set

General Hospital of Thessaloniki "G.Papanikolaou", Thessaloniki, Not set

General Hospital of Thessaloniki 'G. Gennimatas, Thessaloniki, Not set

"Ippokrateio" G.H. of Thessaloniki, Thessaloniki, Not set

General Hospital of Thessaloniki "G.Papanikolaou", Thessaloniki, Not set

PTE-AOK II. Belgyogyaszati Klinika es Nephrologiai Centrum, Pécs, Baranya Vármegye

Lausmed Kft., Baja, Bács-Kiskun Vármegye

Belinus Bt., Debrecen, Hajdu-Bihar Varmegye

Siófoki Kórház, Diabetológiai Szakrendelés, Siófok, Somogy Vármegye

Borbánya Praxis E.Ü. Kft., Nyíregyháza, Szabolcs-Szatmar Varmegye

Szent Margit Rendelőintézet Nonprofit Kft., Budapest, Not set

Békés Megyei Központi Kórház, Gyula, Not set

Endolife Specialty Hospitals, Guntur, Andhra Pradesh

NIZAM'S Institute of Medical Sciences, Hyderabad, Andhra Pradesh

Sunrise Hospital, Vijayawada, Andhra Pradesh

Lifecare Hospital and Research Centre, Bengaluru, Karnataka

Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra

King Edward Memorial Hospital, Pune- Maharashtra, Maharashtra

Maulana Azad Medical College, Delhi, New Delhi

Madras Diabetes Research Foundation, Chennai, Tamil Nadu

Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand

Seino Internal Medicine Clinic, Koriyama-shi, Fukushima, Japan

Nippon Kokan Fukuyama Hospital_Diabetology, Fukuyama-shi, Hiroshima, Not set

Sasaki Internal Medicine, Hokkaido, Not set

Nishiyamado Keiwa Hospital, Ibaraki,, Not set

Kanno Naika_Internal Medicine, Mitaka-shi, Tokyo, Not set

Minami Akatsuka Clinic, Mito-shi, Ibaraki, Not set

Tokyo-Eki Center-building Clinic, Tokyo, Not set

Fukuwa Clinic, Tokyo, Not set

Osteo Medic s.c. Artur Racewicz Jerzy Supronik, Bialystok, Podlaskie

NZOZ Specjalistyczny Osrodek Internistyczno-Diabetologiczny Małgorzata Arciszewska, Bialystok, Podlaskie

Kresmed Sp. z o. o., Bialystok, Podlaskie

M2M Med. Sp. z o.o. Sp. j., Chorzow, Slaskie

M2M Med. Sp. z o.o. Sp. j., Chorzow, Not set

Pratia S.A., Gdynia, Not set

Pratia S.A., Katowice, Not set

Gabinet Lekarski Malgorzata Saryusz-Wolska, Lodz, Not set

Etyka Ośrodek Badań Klinicznych Tomasz Pesta S.K.A., Olsztyn, Not set

Gaja Poradnie Lekarskie, Poznan, Not set

Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych I Administracji, Warszawa, Not set

Centrum Medyczne Oporow, Wroclaw, Not set

Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko, Zabrze, Not set

KARDIO-SANUS, spol. s r.o., Bratislava, Not set

MEDISPEKTRUM s.r.o., Bratislava, Not set

HUMAN-CARE s.r.o., Kosice, Not set

Univerzitna nemocnica L. Pasteura Kosice, Kosice, Not set

Vysokospecializovany odborny ustav geriatricky sv. Lukasa v Kosiciach, n.o., Kosice, Not set

Tatratrial s.r.o., Roznava, Not set

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid

Hospital Fundación Alcorcón, Alcorcon, Not set

Hospital Vall d'Hebron, Barcelona, Not set

Hospital de Bellvitge, Hospitalet de Llobregat, Not set

Hospital Gregorio Marañón, Madrid, Not set

Hospital Universitario de Canarias, Santa Cruz de Tenerife, Not set

Hospital Clínico Universitario de Valencia, Valencia, Not set

Siriraj Hospital, Bangkok Noi, Bangkok

King Chulalongkorn Memorial Hospital, Patumwan, Bangkok

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Mueang Chiang Mai

Thammasat University Hospital, Klong Luang, Pathum Thani

Phramongkutklao Hospital, Bangkok, Not set

Siriraj Hospital, Bangkok, Not set

Conditions: Chronic Kidney Disease, Type 2 Diabetes, Obesity

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Sympatholysis in Chronic Kidney Disease

NCT02411773

Recruiting

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

03/03/2025

Locations: Atlanta VA Medical Center, Decatur, Georgia

Conditions: Chronic Kidney Disease

Learn More ›

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