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Cognitive Decline Clinical Trials
A listing of 42 Cognitive Decline clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 42
There are currently 42 active clinical trials seeking participants for Cognitive Decline research studies. The states with the highest number of trials for Cognitive Decline participants are Illinois, Michigan, Minnesota and California.
Featured Trial
Paid Clinical Studies Nationwide
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Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
Recruiting
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
07/25/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Aging, Cognitive Decline, Older Adults, Cardiovascular, Sedentary Behaviors, Immune Senescence, Motor Function
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
Recruiting
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/16/2025
Locations: University of Washington, Seattle, Washington
Conditions: Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline, Alzheimer's Disease, Dementia, Circadian Dysrhythmia, Sleep Disturbance
Dopaminergic Dysfunction in Late-Life Depression
Recruiting
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments. This triad of findings implicate dopaminergic dysfunction as a core pathophysiologic feature in depression, and may contribute to cognitive decline and motor disability. Normal aging results in brain-wide dopamine declines, decreased D1/D2 receptor density, and loss of dop... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/11/2025
Locations: University of Pittsburgh Medical Center, Pittsburg, Pennsylvania +1 locations
Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
TMS for Cognitive Decline in Aging and Preclinical AD
Recruiting
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease.
This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measur... Read More
Gender:
ALL
Ages:
Between 40 years and 99 years
Trial Updated:
07/09/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
Recruiting
The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from well-established sleep clinics at 4 academic medical centers, with newly diagnosed moderate-severe OSA. An expected 200 OSA patients will be then randomized to one of two groups: i) a 3-month OSA treatment by any combination of PAP, OAT, and positional therapy that results in... Read More
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
06/18/2025
Locations: University of Arizona, Tucson, Arizona +3 locations
Conditions: Obstructive Sleep Apnea, Cognitive Decline
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
Recruiting
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and neurotrophic activity, in elderly adults experiencing early signs of cognitive/memory decline. Extant evidence supports our overarching hypothesis that LPC-DHA supplementation will be more effective than TAG-DHA for increasing central (CSF) DHA levels and improving biomarker... Read More
Gender:
ALL
Ages:
Between 62 years and 80 years
Trial Updated:
06/11/2025
Locations: University of Cincinnati, Department of Psychiatry and Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Recruiting
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute. This information will be used to identify helpful tests to diagnose individuals at risk for developing difficulties with thinking and memory due to their cancer treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/06/2025
Locations: Parkview Cancer Institute, Fort Wayne, Indiana
Conditions: Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change, Chemo-brain, Chemo Fog, Chemotherapy Effect, Cognitive Decline
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
Recruiting
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomarkers. Ninety stage I-III breast cancer patients with mild cognitive difficulties during chemotherapy will be randomized into three groups: MEM+EX, memantine, or placebo. The study will evaluate recruit... Read More
Gender:
FEMALE
Ages:
50 years and above
Trial Updated:
06/03/2025
Locations: Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
Conditions: Breast Cancer, Locally Advanced Breast Cancer, Cognitive Impairment, Cognitive Decline, Cognitive Change, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III
Polyphenols and Cognitive Decline
Recruiting
Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD). The lack of effective treatments makes it essential to develop new strategies for healthy cognitive aging, including interventions to slow or prevent cognitive decline. A traditional Mediterranean diet, rich in polyphenols (PPs), may prevent or delay the onset of cognitive dysfunction in older adults, preserving healthy brain structure and function,... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/30/2025
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Cognitive Decline, Cognitive Dysfunction
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
Recruiting
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy control
Gender:
ALL
Ages:
Between 60 years and 95 years
Trial Updated:
05/21/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Cognitive Impairment, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
Recruiting
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive decline.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
05/19/2025
Locations: Neurobehavioral Systems, Inc., Berkeley, California
Conditions: Alzheimer Disease, Aging, Cognitive Decline
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Recruiting
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are:
* test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes;
* identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and
* examines the mechanis... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/18/2025
Locations: Arizona State University, Phoenix, Arizona
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive Decline, Memory Loss, Memory Impairment
1 - 12 of 42