Search
Cognitive Decline Clinical Trials
A listing of 43 Cognitive Decline clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 43
There are currently 43 active clinical trials seeking participants for Cognitive Decline research studies. The states with the highest number of trials for Cognitive Decline participants are Illinois, Michigan, Minnesota and California.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Chronic Cough Research Study
Recruiting
Are you tired of living with chronic cough? Our research study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough.
You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you!
You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you!
Conditions:
Chronic Cough
Refractory or Unexplained Chronic Cough
Cough
Asthma
Sinusitis
Featured Offer
Lose Weight with GLP-1 Medications
Recruiting
Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to semaglutide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Featured Trial
Stroke Clinical Study
Recruiting
A clinical study for people that suffer with Stroke
Conditions:
Stroke
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Recruiting
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Gender:
ALL
Ages:
Between 40 years and 75 years
Trial Updated:
08/05/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Cognitive Decline, Cognitive Impairment
Preoperative Cognitive Reserve in Older Surgical Patients: a Feasibility Study
Recruiting
Investigators will evaluate feasibility of using a custom 6-game Lumosity brain exercise experience in busy clinical areas to obtain a quick, quantitative measure of cognitive reserve (first gameplay performance \[FGP\]) in older patients presenting for major surgery. Participants in this feasibility trial will serve as a pilot population to estimate postoperative delirium incidence in patients willing and able to complete the brief, self-directed, brain exercise experience on a portable electro... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/21/2025
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Cognitive Decline
Cognitive Status After Removal of Skull Base Meningioma
Recruiting
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/22/2023
Locations: Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Meningioma, Skull Base Meningioma, Frontal Meningioma, Temporal Meningioma, Cognitive Impairment, Cognitive Decline, Post-Surgical Cognition
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
Recruiting
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and neurotrophic activity, in elderly adults experiencing early signs of cognitive/memory decline. Extant evidence supports our overarching hypothesis that LPC-DHA supplementation will be more effective than TAG-DHA for increasing central (CSF) DHA levels and improving biomarker... Read More
Gender:
ALL
Ages:
Between 62 years and 80 years
Trial Updated:
07/30/2025
Locations: University of Cincinnati, Department of Psychiatry and Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
Establishing Clinical Utility Evidence for a Novel Alzheimer's Disease Blood-Based Biomarker Assay
Recruiting
This is a national-level research study of neurologists and dementia specialists. The purpose of this study is to assess the clinical evaluation and management recommendations made by practicing providers for patient simulations with symptoms of cognitive decline.
Gender:
ALL
Ages:
All
Trial Updated:
08/18/2025
Locations: QURE Healthcare, Saint Louis, Missouri
Conditions: Alzheimer Disease (AD), Cognitive Decline
Exercise Adherence and Cognitive Decline
Recruiting
The purpose of this study is to conduct a small-scale test of a goals-based program to help people to exercise more and learn what people like or don't like about the procedures. This program is being designed for individuals aged 45-65 from the Black community. Low levels of physical activity are related to health problems such as heart disease, diabetes, and cognitive decline. People of color are more negatively impacted by these conditions and have also historically been underrepresented by r... Read More
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
08/07/2025
Locations: Aurora Center for Active Adults, Aurora, Colorado +2 locations
Conditions: Cognitive Decline
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
Recruiting
This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional product on self-reported cognitive function and health in adults that reside in the USA. Participants will take their assigned study product (active or placebo) for 8 weeks and answer validated electronic surveys assessing cognitive function delivered to them through a text message (SMS) link or through email.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/05/2025
Locations: Radicle Science, Inc Office, Encinitas, California
Conditions: Aging, Cognitive Decline, Brain Fog, Cognitive Function
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
Recruiting
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
07/25/2025
Locations: Washington University School of Medicine, St. Louis, Missouri
Conditions: Aging, Cognitive Decline, Older Adults, Cardiovascular, Sedentary Behaviors, Immune Senescence, Motor Function
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
Recruiting
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/16/2025
Locations: University of Washington, Seattle, Washington
Conditions: Critical Illness, Delirium, Cognitive Impairment, Cognitive Decline, Alzheimer's Disease, Dementia, Circadian Dysrhythmia, Sleep Disturbance
Dopaminergic Dysfunction in Late-Life Depression
Recruiting
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments. This triad of findings implicate dopaminergic dysfunction as a core pathophysiologic feature in depression, and may contribute to cognitive decline and motor disability. Normal aging results in brain-wide dopamine declines, decreased D1/D2 receptor density, and loss of dop... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/11/2025
Locations: University of Pittsburgh Medical Center, Pittsburg, Pennsylvania +1 locations
Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
TMS for Cognitive Decline in Aging and Preclinical AD
Recruiting
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease.
This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measur... Read More
Gender:
ALL
Ages:
Between 40 years and 99 years
Trial Updated:
07/09/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
Recruiting
The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from well-established sleep clinics at 4 academic medical centers, with newly diagnosed moderate-severe OSA. An expected 200 OSA patients will be then randomized to one of two groups: i) a 3-month OSA treatment by any combination of PAP, OAT, and positional therapy that results in... Read More
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
06/18/2025
Locations: University of Arizona, Tucson, Arizona +3 locations
Conditions: Obstructive Sleep Apnea, Cognitive Decline
1 - 12 of 43