There are currently 33 active clinical trials seeking participants for Fatigue research studies. The states with the highest number of trials for Fatigue participants are Illinois, Ohio, California and Michigan.
Patient-Centered Assessment of Symptoms and Outcomes
Recruiting
Background: The cause of fatigue is not well understood. It can be felt differently by different people. Some people think there are different types of fatigue, with different causes. Researchers think a therapy to treat one type of fatigue in one condition should be able to treat that type of fatigue in other conditions. Objective: To understand the types of fatigue. Eligibility: Adults 18 and older who have felt fatigue for more than a month, and non-fatigued adults Design: Participants... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Fatigue, Cancer, CFS, ME/CFS, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Lupus, Systemic Lupus Erthematosus, Sjogrens
A Pilot rTMS Trial for Neuropsychiatric Symptoms of Long-COVID
Recruiting
This is a pilot randomized trial of rTMS for symptoms of fatigue and brain fog, and other neuropsychiatric symptoms of Long-COVID (Post-COVID, post-acute sequelae of COVID-19 infection, PASC). Twenty participants diagnosed with Long-COVID and recruited from the UCLA Long-COVID clinic will be randomized to receive active rTMS versus sham stimulation for 15 treatments followed by another 15 open-label rTMS treatments. Investigators will compare the safety and tolerability of rTMS vs Sham and exami... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: UCLA Semel Institute, Los Angeles, California
Conditions: Long Covid-19, PASC Post Acute Sequelae of COVID 19, Brain Fog, Fatigue
Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors
Recruiting
The purpose of this research study is to better understand how cancer-related fatigue affects patients and how it's discussed with providers. This information will be used to develop an educational resource (visual aid poster) that could help individuals and their providers talk about cancer-related fatigue and which may help individuals better manage this symptom.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Levine Childrens Hospital Pediatric Cancer and Blood Disorders, Charlotte, North Carolina +2 locations
Conditions: Cancer, Fatigue
Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer
Recruiting
To determine the feasibility of an 8-week fucoidan supplement intervention for patients with fatigue post-cancer treatment and assess changes in fatigue, frailty, and inflammation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: University of Rochester Medical Center, Rochester, New York
Conditions: Fatigue, Inflammation
Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
Recruiting
The primary objective of this study is to conduct a 16-week randomized controlled trial aimed at investigating the effectiveness of the Whole-Diet Approach when following a healthy US-style diet rich in anti-inflammatory properties. The study will focus on evaluating its impact on reducing symptoms related to Post-Acute Sequelae of SARS-CoV-2 Infection (PACS) in adults aged 50 years and older. The main research questions this study aims to answer are: 1. Does adhering to a healthy US-style die... Read More
Gender:
ALL
Ages:
Between 50 years and 94 years
Trial Updated:
07/02/2025
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Post-Acute COVID-19 Syndrome, Fatigue
Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue
Recruiting
Cancer-related fatigue affects at least 30-90% of patients with cancer, depending on the type of cancer and their treatment(s) (e.g., chemotherapy, radiation). It is not relieved by sleep or rest, and it sometimes can persist for years after a person's cancer was treated. The fatigue can be so bad that people cannot return to work, hobbies, family roles, or other daily activities, thereby greatly reducing quality of life. The causes of this fatigue are unknown, and we currently do not have anyth... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Neoplasms, Blood Cancer, Fatigue, Diet Habit, Survivorship, Fasting, Intermittent
A Trial of a Positive Psychology Intervention for Older Adults (RESET) During the COVID-19 Pandemic
Recruiting
The heightened vulnerability to COVID-19 of African American older adults in Detroit, Michigan and other marginalized communities is linked to systemic racism experienced over the life course. Structural inequities also magnify the pandemic's impact on older adults' physical and psychosocial functioning. Many older adults in Detroit, burdened by poor health even before the pandemic, face a downward spiral of increased distress, reduced physical and social activity, and physical deconditioning. R... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
06/25/2025
Locations: University of Michigan, Ann Arbor, Michigan +1 locations
Conditions: Depressive Symptoms, Anxiety, Chronic Pain, Fatigue, Loneliness, Stress, Psychological
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
Recruiting
To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study. In this study, BLT, Methylphenidate and Melatonin will be compared to their placebos.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: MD Anderson Cancer Center, Houston, Texas
Conditions: Sleep, Fatigue, Anxiety, Cancer, Depression
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
Recruiting
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
05/09/2025
Locations: University of California Davis Health, Sacramento, California +1 locations
Conditions: Chronic Kidney Diseases, Metabolic Acidosis, Fatigue, Physical Endurance, Insulin Resistance, Mitochondrial Energetics, Diabetes
Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers
Recruiting
To find out if combining psychoeducational interventions (such as education, counseling, and self-managed therapies) with an open-label placebo can help to improve your quality of life better than either the psychoeducational interventions or the placebo alone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: MD Anderson Cancer Centerr, Houston, Texas
Conditions: Metastatic Cancers, Fatigue
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors
Recruiting
The primary goal of this project is to determine the effects of exercise on the gut microbiome in breast cancer survivors and determine how these changes may relate to psychosocial symptoms such as fatigue.
Gender:
FEMALE
Ages:
Between 18 years and 74 years
Trial Updated:
04/10/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Breast Cancer, Gut Microbiome, Exercise, Fatigue
Active Living After Cancer: Implementation Within Be Well Acres Homes
Recruiting
The goal of this research study is to learn more about a physical activity program adapted for cancer survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: The University of Texas M. D. Anderson Cancer Center, Houston, Texas
Conditions: Cancer, Fatigue