There are currently 324 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and New York.
ReNEW Clinic Cohort Study
NCT03816462
Recruiting
This is an ongoing, prospective cohort study of children and young adults who are evaluated in the Reversing the Negative Effects of Weight on the Heart (ReNEW) Clinic at Johns Hopkins University. Demographic and clinical data of patients who agree to participate are obtained via chart review and entered into a longitudinal clinic registry.
Gender:
ALL
Ages:
22 years and below
Trial Updated:
01/15/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Hypertension, Prehypertension, Obesity, Overweight, Left Ventricular Hypertrophy, Elevated Blood Pressure
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Insulin Regulation of Lipolysis and Lipolysis Proteins
NCT03866408
Recruiting
These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/15/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Obesity
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Graded Insulin Suppression Test P&F
NCT06592261
Recruiting
The goal of this study is to learn about how the hormone insulin controls blood sugar in a variety of people. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level. Participants will be asked to come in for a one-day study visit in which they will undergo a "graded insulin suppression test" ("GIST"). The GIST involves intravenous (into the vein) infusions of octreotide, a medication that turns off the body's own production of... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/14/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Insulin Resistance, Hyperinsulinemia, Obesity, Healthy
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Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
NCT05561595
Recruiting
Stigma due to health conditions increases disease burden and adversely impacts health. The internalization of health-related stigma is associated with impaired mental health and quality of life. The current project will test the effects of a novel, transdiagnostic, group counseling intervention, and peer support, to determine the optimal method for helping patients cope with health-related stigma, reducing its internalization, and enhancing patient quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Obesity, Skin Disease, Cancer, HIV, Diabetes, Chronic Pain
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First in Human Study in Subjects With Obesity, But Otherwise Healthy
NCT06252220
Recruiting
This is a First in Human study to evaluate the safety and tolerability of DA-1726 following single and multiple doses in participants with obesity, but otherwise healthy subjects.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/14/2025
Locations: Clinical Pharmacology of Miami, LLC, Miami, Florida
Conditions: Obesity
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Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery
NCT05975580
Recruiting
This is a randomized controlled trial employing a Sequential Multiple Assignment Randomized Trial (SMART) design to test whether pharmacotherapy, in conjunction with lifestyle counseling, can reverse weight regain after bariatric surgery.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/13/2025
Locations: University of California Irvine Medical Center, Orange, California
Conditions: Obesity
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Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function
NCT06776081
Recruiting
Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified due to their potential as circulating biomarkers of adipose tissue health and systemic messengers, regulators and mediators of cardiometabolic health and disease with obesity. The investigators hypothesize that elevated Ad-EVs in adults with obesity will be n... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/09/2025
Locations: University of Colorado Boulder Clinical and Translational Research Center (CTRC), Boulder, Colorado
Conditions: Obesity, Weight Loss
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Adrenergic Cholinergic Enteric Measures/Mapping
NCT04013282
Recruiting
Patients seen who had autonomic and enteric profiling (Adrenergic, Cholinergic, Enteric Measures/Mapping=ACEM_ from 2012-2019 at the University of Louisville.
Gender:
ALL
Ages:
Between 10 years and 80 years
Trial Updated:
01/08/2025
Locations: University of Louisville, Louisville, Kentucky
Conditions: Obesity
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SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial
NCT04972721
Recruiting
Participants are being asked to participate in SELECT-LIFE study because participants take part in the SELECT trial. SELECT-LIFE study is a survey-based study that will start when the SELECT trial ends. SELECT-LIFE looks at the long-term effects of participants taking part in the SELECT trial including the trial medicine participants have been taking. When the SELECT trial ends, participants will no longer get the medicine participants got in the study, even if participants decide to take par... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
01/08/2025
Locations: Master Centre for USA, Plainsboro, New Jersey +37 locations
Conditions: Overweight, Obesity
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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
NCT06105164
Recruiting
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/08/2025
Locations: McLean Hospital, Belmont, Massachusetts +1 locations
Conditions: Appetitive Behavior, Obesity
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A First-in-human Research Study on How NNC0662-0419 Works in People Living With Overweight or Obesity
NCT06737536
Recruiting
This study is testing a new study medicine which may be used to treat people living with overweight or obesity. The purpose of the study is to see if the new study medicine is safe, how it works in human body and what human body does to the study medicine. Participants will either get the study medicine NNC0662-0419 or placebo (a "dummy" medicine without any active ingredients) given by study staff as an injection under participants skin. Which treatment participants will get is decided by chanc... Read More
Gender:
ALL
Ages:
Between 19 years and 55 years
Trial Updated:
01/06/2025
Locations: Celerion, Lincoln, Lincoln, Nebraska
Conditions: Overweight, Obesity
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Diazoxide Suppression Test P&F Study
NCT06606327
Recruiting
The goal of this study is to learn about how the hormone insulin controls blood sugar. The main question it aims to answer is about how much insulin the body actually needs to maintain a normal blood sugar level. People with obesity and high insulin levels will receive eight doses of diazoxide, a drug that suppresses the pancreas's production of insulin, and will have their fasting blood sugar and insulin levels checked daily while taking the drug.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/06/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Insulin Resistance, Hyperinsulinemia, Obesity
Register for Updates