There are currently 341 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and New York.
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
NCT05723679
Recruiting
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
Gender:
All
Ages:
Between 55 years and 90 years
Trial Updated:
04/23/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Heart Failure With Preserved Ejection Fraction, Obesity
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Competency Based Approaches for Community Health 2
NCT04971044
Recruiting
One-size-fits-all approaches have failed to demonstrate sustained effects on childhood obesity, especially among low-income minority families, who experience constantly changing barriers to engaging in health behavior. Addressing obesity in these populations requires intervening in early childhood and situating interventions in the context of families and communities. Developing personalized childhood obesity prevention interventions with sustained effectiveness that support families in health b... Read More
Gender:
All
Ages:
4 years and above
Trial Updated:
04/23/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Obesity
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The Weight of Cardiovascular Disease
NCT06053645
Recruiting
The purpose of this study is to evaluate the impact of a cardiometabolic clinic on percent body weight loss, body mass index (BMI), and visceral adiposity distribution in obese adults with cardiovascular disease (CVD) at 12 months.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cardiovascular Diseases, Obesity
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Activity, Adiposity, and Appetite in Adolescents 2 Intervention
NCT05443347
Recruiting
The objective of the study is to quantify the relationship between physical activity, metabolic function, and appetite in adolescents. To do this we will test our working hypothesis that high levels of regular moderate-to-vigorous physical activity (MVPA), as opposed to body weight status, results in a metabolic phenotype consisting of enhanced metabolic function and proper regulation of appetite. We will randomly assigning sedentary overweight/obese adolescents (N=44) to either a control or str... Read More
Gender:
All
Ages:
Between 14 years and 17 years
Trial Updated:
04/22/2024
Locations: Children's Mercy Kansas City, Kansas City, Missouri
Conditions: Obesity, Energy Balance, Appetite, Metabolism, Insulin Sensitivity
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Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
NCT06129110
Recruiting
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/22/2024
Locations: University of Colorado Anschutz, Aurora, Colorado
Conditions: Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity, Insulin Resistance
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EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
NCT05093634
Recruiting
The protocol describes a randomized, double-blind, placebo-controlled trial with independent sub-studies of setmelanotide in patients with obesity and at least one of the specific gene variants in the Melanocortin-4 Receptor pathway: POMC or PCSK1 (Sub-study 035a) LEPR (Sub-study 035b) SRC1 (Sub-study 035c) SH2B1 (Sub-study 035d) The objectives and endpoints are identical for these sub-studies.
Gender:
All
Ages:
Between 6 years and 65 years
Trial Updated:
04/19/2024
Locations: Phoenix Children's Hospital, Phoenix, Arizona +55 locations
Conditions: Obesity, Genetic Obesity
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A Study of LY3841136 in Overweight and Obese Participants
NCT06345066
Recruiting
The main purpose of this study is to assess the safety and tolerability of LY3841136 when administered in combination with tirzepatide in overweight and obese patients. The study will last up to approximately 42 weeks.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/18/2024
Locations: Fortrea CRU, Inc., Daytona Beach, Florida +2 locations
Conditions: Obesity, Overweight
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A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943
NCT06313528
Recruiting
The main purpose of the study is to look at the effect of the study drug compared to placebo on calorie intake, energy metabolism, and appetite. The study will last up to 6 months and may include up to 20 visits.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/18/2024
Locations: AdventHealth Orlando, Orlando, Florida +2 locations
Conditions: Obesity
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First in Human Study in Subjects With Obesity, But Otherwise Healthy
NCT06252220
Recruiting
This is a First in Human study to evaluate the safety and tolerability of DA-1726 following single and multiple doses in participants with obesity, but otherwise healthy subjects.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2024
Locations: Clinical Pharmacology of Miami, LLC, Miami, Florida
Conditions: Obesity
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Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes
NCT05925920
Recruiting
Single center, single-dose, randomized, placebo-controlled, dose-escalating study to evaluate, safety, tolerability, pharmacokinetics, and pharmacodynamics of escalating doses of ENT-03S in obese but otherwise healthy subjects and in subjects with obesity and Type 2 diabetes.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/16/2024
Locations: ProSciento, San Diego, California
Conditions: Obesity, Diabetes Mellitus, Type 2
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Reducing Obesity Using Social Ties Program
NCT06335810
Recruiting
This trial aims to test the feasibility and acceptability of addressing interpersonal barriers to weight-related behavior change. Specifically, the study will test if, by including up to two friends, family members, or co-workers in a lifestyle intervention for weight loss, the person enrolled in the study loses more weight than someone whose friends, family members, or co-workers were not invited to participate.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Weill Cornell Urology, Brooklyn, New York +3 locations
Conditions: Obesity
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Effect of PDE5 Inhibition on Adipose Metabolism in Humans
NCT04684589
Recruiting
This is a randomized, double-blinded, placebo-controlled study of the effects of PDE5 inhibition with tadalafil on adipose tissue in obese individuals. Adipose metabolism will be measured using magnetic resonance imaging (MRI) scans and by aspirating a small amount of adipose to measure gene expression.
Gender:
All
Ages:
Between 19 years and 50 years
Trial Updated:
04/15/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Obesity
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