There are currently 324 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and New York.
Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study
NCT06730113
Recruiting
Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective: To learn more about factors, including type 2 diabetes, that may cause vascular disease in young people. Eligibility: People aged 12 to 25 years who (1) have type 2 diabetes; (2) are overweight... Read More
Gender:
ALL
Ages:
Between 12 years and 25 years
Trial Updated:
05/08/2025
Locations: Children's National Hospital (CNH), Washington, District of Columbia +1 locations
Conditions: Obesity, Type 2 Diabetes
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STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
NCT06571383
Recruiting
The study is testing how well semaglutide can help adolescents with excess body weight to lose weight and to maintain weight loss. All participants in the study will receive semaglutide as a weekly injection. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. All participants will get semaglutide treatment for a minimum of 3 years.
Gender:
ALL
Ages:
Between 12 years and 15 years
Trial Updated:
05/07/2025
Locations: Neighborhood Healthcare, Escondido, California +95 locations
Conditions: Obesity
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Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858839
Recruiting
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/07/2025
Locations: Pinnacle Research Group LLC, Anniston, Alabama +101 locations
Conditions: Obesity
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Stepped Care for Weight Loss Maintenance
NCT06151145
Recruiting
This study is a 3-group, parallel design, randomized controlled trial (RCT) in approximately 258 adults with obesity that will investigate whether a 16-week behavioral weight loss treatment and a 52-week stepped-care digital health intervention can improve the maintenance of a ≥ 5% weight loss. 16-week run-in (Phase 1). To qualify for randomization, participants must lose ≥ 5% of initial weight in the 16-week run-in. This loss will be achieved with the provision of weekly-group lifestyle counse... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/06/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Obesity
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Weight Loss Study: Genetics and Response to Naltrexone/Bupropion
NCT05919797
Recruiting
The goal of this clinical trial is to understand if genetic variations are associated with the amount of weight loss with diet and while taking an FDA-approved medication for weight loss. The main question\[s\] it aims to answer are: * In Aim One, the investigators propose to rigorously test the hypothesis that presence of the Taq1A A1+ polymorphism is associated with greater weight loss with NB compared with the A1- genotype. * In Aim Two, the investigators will explore other genetic polymorph... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/05/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: Obesity
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Strategies for Improving Remote-based Weight Loss (PATH Trial)
NCT06166225
Recruiting
The purpose of this study is to examine whether the addition of online yoga classes, compared to health and wellness classes, can improve the amount of weight loss produced from an Internet-based weight loss program. All individuals will receive a 12-month, automated Internet-based weight loss program. Following 3 months of of weight loss treatment, individuals will be randomized to also receive yoga classes or health and wellness classes for 9 months. Assessments will occur at baseline, 3, 6, 1... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/05/2025
Locations: The Miriam Hospital's Weight Control and Diabetes Research Center, Providence, Rhode Island
Conditions: Obesity
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Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
NCT06582875
Recruiting
The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body's response to glucose and insulin, can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese. The study will also evaluate changes in abdominal fat and kidney metabolism using cutting-edge images techniques. Blood and urine samples will provide further insight... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/05/2025
Locations: University of Colorado - Anschutz Medical Campus, Aurora, Colorado
Conditions: Autosomal Dominant Polycystic Kidney, Obesity
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Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
NCT01927783
Recruiting
Background: - Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders. They will collect information about the health and health needs of people in mostly Black churches in DC. They will study things that affect heart health, like diabetes, blood pressure, cholesterol, and weight. They will also study how technology can keep track of activities and health. The information will s... Read More
Gender:
ALL
Ages:
Between 19 years and 85 years
Trial Updated:
05/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Cardiovascular Disease, Obesity
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Physical and Behavioral Traits of Overweight and Obese Adults
NCT00428987
Recruiting
This study will describe the phenotype (physical and behavioral traits) of overweight and obese people. It will characterize the hormones, metabolism, food preferences, fitness and physical activity levels, sleep patterns and thought processes in people with and without weight problems. Genetic material will be collected for studies of the internal codes that influence body weight. People over 18 years of age from all weight categories (lean, overweight, obese) who are reasonably healthy may be... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Obesity, Healthy Volunteers
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Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
NCT06007404
Recruiting
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.
Gender:
ALL
Ages:
Between 14 years and 18 years
Trial Updated:
05/03/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes
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TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
NCT06802081
Recruiting
This is a single center randomized double blind controlled study of patients (BMI\> 30 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom severity, and burden of AFIB at 12 months.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/02/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Atrial Fibrillation, Obesity
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Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism
NCT05290064
Recruiting
Protocol Number: 22DK0002 Title: Effects of Ultra-processed versus Unprocessed Diets on Energy Metabolism Background: Many diets worldwide include both processed and unprocessed foods. Researchers want to study the effects these foods have on a person s health. Objective: To study how different diets affect a person s health and metabolism. Eligibility: Adults aged 18 60 without diabetes who have stable weight and can exercise. Design: Participants will be screened with: Medical histor... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Diet, Obesity
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