There are currently 343 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and New York.
Food at Home Study
NCT06286514
Recruiting
The study objective is to develop an accessible home food environment assessment toolkit that includes valid and reliable paper and electronic tools targeting foods known to impact diet-related health that can be user-administered across literacy levels in English and Spanish.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Obesity, Diet, Healthy
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Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
NCT06325722
Recruiting
Background: In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks. Participants who received the low-carbohydrate diet first lost more body fat at the end of the study than those who received the low-fat diet first. Researchers want to see if they can repeat that result in a longer weight loss study when participants live at home. Objective: To test the effects... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/21/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Overweight, Obesity
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Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858839
Recruiting
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/20/2025
Locations: Pinnacle Research Group LLC, Anniston, Alabama +52 locations
Conditions: Obesity
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Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
NCT05653258
Recruiting
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Obesity, Healthy Lifestyle
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Thermogenic Silencer Regulatory Factors in Humans
NCT06424132
Recruiting
A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST). A critical limitation with NST as a therapeutic option, however, is that this beneficial process is silenced under human physiological temperature conditions and the mechanisms of how this occurs is unknown. This study will be the first to identify human NST silencing factors that may be targeted for the treatment of obesity and metabolic disorders.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
03/19/2025
Locations: Rockefeller University, New York, New York
Conditions: Obesity, Metabolic Disease, Cold Exposure
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Early Tracking of Childhood Health Determinants (ETCHED) Study
NCT03481829
Recruiting
Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term effects on the child s health. Children who become overweight or obese during childhood tend to remain so as adults. Researchers want to study many risk factors during and after pregnancy, and how these affect a child s development. They will also follow the mother s he... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
03/19/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Fatty Liver, Diabetes Mellitus
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Diabetes and Heart Disease Risk in Blacks
NCT00001853
Recruiting
It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to associate obesity with the presence of heart disease risk factors. Risk factors that will be studied include; total body fat, body fat distribution, fat content of the blood (triglyceride concentrati... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/19/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Diabetes, Obesity, Hypertension, Cardiovascular Diseases
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A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo
NCT06131372
Recruiting
This study will look if CagriSema can lower kidney damage in people with chronic kidney disease (CKD), type 2 diabetes (T2D) and overweight or obesity. CagriSema is a new investigational medicine. CagriSema cannot yet be prescribed by doctors. The study will compare CagriSema to the 2 medicines semaglutide and cagrilintide, when they are taken alone. It will also compare CagriSema to a "dummy" medicine (also called placebo) without any active ingredient. Participant will either get CagriSema, se... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2025
Locations: John Muir Physicians Network, Concord, California +139 locations
Conditions: Chronic Kidney Disease, Type 2 Diabetes, Obesity
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Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients
NCT06466161
Recruiting
The diagnosis of hypertensive disease during pregnancy is predicated on strict blood pressure thresholds: 140/90 on at least two occasions measured four hours apart for both gestational hypertension and preeclampsia. An improvement in diagnostic accuracy of even 5mm Hg would be significant, as reflected by the US Association for the Advancement of Medical Instrumentation (AAMI), the British Hypertension Society, the European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Moni... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/18/2025
Locations: Prentice Women's Hospital, Chicago, Illinois
Conditions: Hypertension in Pregnancy, Hypertension, Obesity
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Synchronous vs Asynchronous Remotely Delivered Lifestyle Interventions
NCT06393725
Recruiting
The goal of this clinical trial is to learn if a group-based digital weight loss program that is delivered asynchronously (via an online platform) is as effective as one that is delivered synchronously (via weekly videoconference meetings). In the asynchronous condition, participants can engage with their group any time 24/7. In the synchronous condition, participants can engage with their group once a week at a videoconference meeting. The main questions it aims to answer are: Will participant... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/18/2025
Locations: University of Connecticut, Storrs, Connecticut
Conditions: Obesity
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A Single-center Study of Setmelanotide in Patients With Prader-Willi Syndrome
NCT06772597
Recruiting
This is a Phase 2, single-center, open-label study designed to assess the safety and efficacy of setmelanotide in patients with obesity due to Prader-Willi Syndrome (PWS) who are 6 to 65 years of age. Up to 20 patients are planned to be enrolled. Patients will take a daily subcutaneous dose of open-label setmelanotide for up to 26 weeks.
Gender:
ALL
Ages:
Between 6 years and 65 years
Trial Updated:
03/18/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Prader-Willi Syndrome, Obesity, Hyperphagia
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Mechanisms Underlying Individual Variations of Taste and Smell in Obesity
NCT04714892
Recruiting
Background: Changes to the sense of taste or smell can change eating behavior. This may contribute to obesity. Researchers want to see how taste and smell perceptions that affect food choices may differ between people with obesity and without obesity. Objective: To understand the role that senses of taste and smell play in food intake. Eligibility: Adults ages 18-65 with obesity and without obesity Design: Participants will be screened with a medical history and physical exam. They will h... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/18/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Obesity
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