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Obesity Clinical Trials
A listing of 320 Obesity clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 320
There are currently 320 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and North Carolina.
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Obese or Overweight Volunteers Needed for a Research Study
Recruiting
Enroll now in a research study for obese or overweight volunteers with heart disease, hypertension, T2DM, or high cholesterol. All study related assessments are provided at no cost. Compensation up to $125 per visit for qualified participants.
Conditions:
Obesity
Overweight
Overweight and Obesity
Diabetes Mellitus
Type 2
Featured Trial
Psoriasis & Overweight Clinical Study
Recruiting
Have you tried different treatments for psoriasis while also managing your weight? Are you:
- Diagnosed with plaque psoriasis
- Struggling with weight management
- at least 18 years old
A clinical trial may be an option for you. Learn more about the TOGETHER-PsO study and see if you may be eligible to participate.
- Diagnosed with plaque psoriasis
- Struggling with weight management
- at least 18 years old
A clinical trial may be an option for you. Learn more about the TOGETHER-PsO study and see if you may be eligible to participate.
Conditions:
Overweight
Overweight and Obesity
Obesity
Psoriasis
Plaque Psoriasis
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
Recruiting
Background:
- Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected individuals may be asked to provide blood and other samples and may undergo tests to evaluate the heart, blood vessels and lung function. The testing is tailored to the individual and/or condition being... Read More
Gender:
ALL
Ages:
Between 1 year and 100 years
Trial Updated:
07/31/2025
Locations: Suburban Hospital, Bethesda, Maryland +1 locations
Conditions: Cardiomyopathy, Li-Fraumeni Syndrome, Atherosclerosis, Metabolic Disease, Obesity, Inflammatory Disease
Social Determinants of Sleep and Obesity
Recruiting
African American adults sleep less and obtain worse quality sleep compared to the national average, and emerging evidence links inadequate sleep with greater morbidity and mortality from chronic diseases such as diabetes, obesity, and cancer. To address this public health concern, the proposed research seeks to use a multi-method approach to adapt a sleep intervention for African American adults with overweight/obesity not meeting national sleep duration or physical activity recommendations. The... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
07/31/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Insufficient Sleep, Physical Inactivity, Sedentary Behavior, Obesity
Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
Recruiting
Background:
In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks. Participants who received the low-carbohydrate diet first lost more body fat at the end of the study than those who received the low-fat diet first. Researchers want to see if they can repeat that result in a longer weight loss study when participants live at home.
Objective:
To test the effects... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Overweight, Obesity
MEHMO Natural History and Biomarkers
Recruiting
This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have symptoms such as intellectual delay, seizures, abnormal hormone and blood sugar levels, and decreased motor skills.
No current treatment for these conditions is available. A major impediment to the testing of potential therapeutic interventions is the lack of well-defined o... Read More
Gender:
ALL
Ages:
Between 1 week and 100 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Intellectual Disability, Epilepsy, Hypogonadisms, Microcephaly, Nervous System Malformations, Obesity
Children s Growth and Behavior Study
Recruiting
Background:
- Studies show that many factors affect children's eating behavior and health. These include sleep, mood, thinking skills, and genetics. Studying children over time may identify children at higher risk for eating-related health concerns.
Objective:
- To understand how genes and environment influence eating behavior and health over time.
Eligibility:
- Children ages 8-17 in good general health.
Design:
* Screening visit 1: Medical history, physical exam, body measurements, and... Read More
Gender:
ALL
Ages:
Between 8 years and 100 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Obesity, Eating Behaviors, Healthy Volunteers
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
Recruiting
Background:
At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem.
Objective:
To test how (1) a low-carbohydrate diet and (2) a supplement called nicotinamide riboside (NR) affect how a person s body uses dietary fat.
Eligibility:
Men aged 18 to 65 and women aged 18 to 50 who are healthy volunteers with a body mass index (height to weight ratio) of 25 or more. Adults wi... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Overweight, Obesity
Effect of Ultra-processed Versus Unprocessed Diets on Energy Metabolism
Recruiting
Protocol Number: 22DK0002
Title: Effects of Ultra-processed versus Unprocessed Diets on Energy Metabolism
Background:
Many diets worldwide include both processed and unprocessed foods. Researchers want to study the effects these foods have on a person s health.
Objective:
To study how different diets affect a person s health and metabolism.
Eligibility:
Adults aged 18 60 without diabetes who have stable weight and can exercise.
Design:
Participants will be screened with:
Medical histor... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Diet, Obesity
Early Tracking of Childhood Health Determinants (ETCHED) Study
Recruiting
Background:
Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term effects on the child s health. Children who become overweight or obese during childhood tend to remain so as adults. Researchers want to study many risk factors during and after pregnancy, and how these affect a child s development. They will also follow the mother s he... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
07/31/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Fatty Liver, Diabetes Mellitus
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Recruiting
Background:
Diet-induced thermogenesis (DIT) is the amount of energy one s body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet can affect DIT.
Objective:
To learn how different diets can change a person s DIT.
Eligibility:
Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6 months.
De... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/31/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Conditions: Obesity, Normal Physiology, Healthy Volunteers
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
Recruiting
This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person eats and weight loss over 4 weeks. It will also compare weight changes in people who attend weight loss counseling sessions and those who do not over this period of time.
Obese, non-diabetic people between 18 and 60 years of age who are in good health and who live in the... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/31/2025
Locations: NIDDK, Phoenix, Phoenix, Arizona
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
Recruiting
Background:
- Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders. They will collect information about the health and health needs of people in mostly Black churches in DC. They will study things that affect heart health, like diabetes, blood pressure, cholesterol, and weight. They will also study how technology can keep track of activities and health. The information will s... Read More
Gender:
ALL
Ages:
Between 19 years and 85 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Cardiovascular Disease, Obesity
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Recruiting
This study will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part study with a double-blind period and an open-label extension (OLE). The... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/30/2025
Locations: SEC Clinical Research, Dothan, Alabama +33 locations
Conditions: Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction, Obesity
1 - 12 of 320