There are currently 323 active clinical trials seeking participants for Obesity research studies. The states with the highest number of trials for Obesity participants are California, Texas, Florida and North Carolina.
Comparison of Body Composition Changes With Weight Loss Interventions
NCT07115069
Recruiting
This study is being done to compare the effects of a newer class of weight loss medications to weight loss surgery on the body's muscle, metabolism, and side effects over time. People with severe obesity often lose weight using either medications like GLP-1 receptor agonists (such as semaglutide or tirzepatide) or by having bariatric surgery, such as gastric bypass. While both approaches can lead to weight loss, they may affect the body in different ways. The investigators are inviting adult pa... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
08/20/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Obesity
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Redefining BMI: The Body, Mind, and Inflammation Trial
NCT06532747
Recruiting
Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women. The primary purpose of this study is to test the preliminary efficacy of the intensive lifestyle intervention for EA women in reducing adiposity, as well as improving biomarkers of inflammation and metabolic risk over 12 months compared with a traditional behavioral weight loss intervention. This treatment program will be teste... Read More
Gender:
FEMALE
Ages:
Between 18 years and 25 years
Trial Updated:
08/19/2025
Locations: Virginia Commonwealth Universtity, Richmond, Virginia
Conditions: Obesity, Adiposity
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Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
NCT05945355
Recruiting
This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway Dysfunction (SAD) to obesity-related versus non-obesity-related asthma. The study will involve training (IT) for 8 weeks at three intensity levels (SHAM, low and high). Target dose: 150 inspirations t... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
08/18/2025
Locations: Duke Health Center Creekstone, Durham, North Carolina +1 locations
Conditions: Asthma in Children, Obesity, Pediatric Obesity, Pediatric Asthma
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Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
NCT04838678
Recruiting
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/18/2025
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Hypertension, Obesity
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Fibrosis Lessens After Metabolic Surgery
NCT06374875
Recruiting
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity, diabetes, and dyslipidemia. MASLD is currently the most common cause of chronic liver disease affecting about 80% of people with obesity, ranging from simple fat deposits in the liver to Metabolic Dysfunction-Associated Steatohepatitis (MASH), cellular injury, advanced fibrosis, cirrhosis, or hepa... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/18/2025
Locations: Banner Health Center, Phoenix, Arizona +21 locations
Conditions: Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis, Obesity
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A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
NCT06439277
Recruiting
The goal of the study is to assess how tirzepatide impacts bodyweight and cardiovascular risk factors when used in conjunction with healthy nutrition and physical activity in adolescents with obesity and multiple weight related comorbidities. The study will last approximately 76 weeks and may include up to 23 visits. Participants who have completed the primary 72-week GPIX study and have been off treatment for no more than 12 weeks (including the 4-week safety follow-up period), will have the o... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
08/15/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +72 locations
Conditions: Obesity, Weight Gain
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Evaluation of Child Care Staff Weight Management Program
NCT05656807
Recruiting
The goal of this 12-month cluster clinical trial is to evaluate if improving child care providers' health behaviors using an online provider weight management program elicits meaningful change in dietary and physical activity behaviors in 2-5-year-old preschool children in their care and the child care environment. The study sample will include 84 child care centers. Including: 84 center directors, 168 2-5-year-old classroom teachers, 672 2-5-year old children. Some centers will do only the on... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
08/15/2025
Locations: UNC Center for Health Promotion and Disease Prevention, Chapel Hill, North Carolina
Conditions: Obesity
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WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time
NCT06963736
Recruiting
The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact that evening screen time may have on your health.
Gender:
ALL
Ages:
26 years and above
Trial Updated:
08/15/2025
Locations: Arizona State University, Tempe, Arizona
Conditions: Sedentary Time, Cardiovascular Diseases, Prediabetes, Obesity
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Effect of Ketone Esters on Liver Fat Content and Metabolic Function
NCT07097506
Recruiting
The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control. Ketones are a type of energy source made by the body during times of weight loss, low carbohydrate intake and starvation. People enrolled in this study will be randomly assigned (by chance, like the flip of a coin) to one of two groups: Group 1: Ketone ester drink consumed daily for 6 weeks. Group 2: Placebo drink consumed daily for 6 weeks.
Gender:
ALL
Ages:
Between 18 years and 22 years
Trial Updated:
08/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity
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Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
NCT01927783
Recruiting
Background: - Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders. They will collect information about the health and health needs of people in mostly Black churches in DC. They will study things that affect heart health, like diabetes, blood pressure, cholesterol, and weight. They will also study how technology can keep track of activities and health. The information will s... Read More
Gender:
ALL
Ages:
Between 19 years and 85 years
Trial Updated:
08/13/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Cardiovascular Disease, Obesity
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Investigating the Impact of Obesity on Pubertal Development in Girls
NCT02583646
Recruiting
Background: Studies suggest that overweight girls may be developing breast tissue, and therefore starting puberty, earlier than normal weight girls. However, it is hard to distinguish breast tissue from fatty tissue. Researchers think that by using breast ultrasound, among other tests, they can do a better job of telling whether an overweight girl has breast tissue. This will help them understand if overweight girls are truly entering puberty before normal weight girls. Objective: To find out... Read More
Gender:
FEMALE
Ages:
Between 8 years and 14 years
Trial Updated:
08/13/2025
Locations: NIEHS, Research Triangle Park, Research Triangle Park, North Carolina
Conditions: Obesity, Puberty, Normal Physiology
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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433
Recruiting
The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.
Gender:
ALL
Ages:
Between 45 years and 99 years
Trial Updated:
08/13/2025
Locations: Eastern Shore Research Institute, Fairhope, Alabama +76 locations
Conditions: Atherosclerotic Cardiovascular Disease, Overweight, Obesity
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