There are currently 48 active clinical trials seeking participants for Prediabetes research studies. The states with the highest number of trials for Prediabetes participants are Shanghai, California, New York and Ontario.
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
NCT06424106
Recruiting
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
03/21/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: PreDiabetes
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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NCT06112418
Recruiting
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
03/17/2025
Locations: Chandler Clinical Trials, Chandler, Arizona +76 locations
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
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Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
NCT06025292
Recruiting
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.
Gender:
ALL
Ages:
Between 40 years and 60 years
Trial Updated:
03/12/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Hyperglycaemia (Non Diabetic), Prediabetes
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Continuous Glucose Monitoring in Prediabetes with Health Education Videos
NCT06883812
Recruiting
The objective of this project is to deliver a behavior health education video series that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and video clips generated by artificial intelligence (AI) software to improve glycemic control among individuals with prediabetes. The goal is to prevent transition to type 2 diabetes and advanced metabolic complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Southern California Center for Latino Health SCCLH, Los Angeles, California
Conditions: Prediabetes
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MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
NCT03504683
Recruiting
One in three American adults have prediabetes, and up to 70% of adults with prediabetes eventually develop type 2 diabetes. With the high cost of treating diabetes, cost-effective approaches are needed to reduce the incidence of diabetes. One new strategy may be to change when people eat. Studies in rodents suggest that a form of intermittent fasting that limits eating to a short time period each day and involves fasting for the rest of the day (time-restricted eating; TRE) improves blood sugar... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
03/05/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: PreDiabetes
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Peanuts for Cardiometabolic, Brain, and Intestinal Health
NCT06867198
Recruiting
The overall objective of this 13-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially diverse prediabetes population.
Gender:
ALL
Ages:
Between 20 years and 59 years
Trial Updated:
03/04/2025
Locations: Georgia State University, Atlanta, Georgia
Conditions: Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function, Gut Microbiota, Endothelial Function (reactive Hyperemia), Arterial Stiffness, Blood Pressure, Adult
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The YMCA Healthy Lifestyle Program for Prediabetes
NCT06841796
Recruiting
The goal of this 26 week randomized controlled clinical trial is to learn if using a real time continuous glucose monitor (CGM) in a healthy lifestyle program for adults with prediabetes at the YMCA can improve glucose levels, dietary habits and physical activity The main questions it aims to answer is * Does use of a CGM improve the percent of time spent with glucose values between 70-140 mg/dl * Does use of a CGM improve nutritional habits as measured by Picture Your Plate (PYP) score * Does... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2025
Locations: YMCA of the Blue Water Area, Port Huron, Michigan
Conditions: PreDiabetes
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Role of Insulin Action in Psoriasis Pathogenesis
NCT06242847
Recruiting
The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis. The main question it aims to answer is if insulin action is preserved or even enhanced in psoriatic lesions despite insulin resistance elsewhere. Participants with plaque psoriasis will have punch biopsies taken of lesional and non-lesional skin after an overnight fast and then during an oral glucose tolerance test. Biopsy specimens wi... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/17/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Psoriasis, Plaque Psoriasis, Insulin Resistance, PreDiabetes, Overweight and Obesity
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Night Owl Metabolism
NCT06507722
Recruiting
The proposed study uses a novel and rigorous randomized cross-over study design in youth (17-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo tw... Read More
Gender:
ALL
Ages:
Between 18 years and 23 years
Trial Updated:
02/11/2025
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: PreDiabetes, Overweight, Impaired Glucose Tolerance
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Evaluation of Empagliflozin vs Standard Care in Veterans With Prediabetes
NCT06828731
Recruiting
Prediabetes effects 96 million people 18 years of age or older. It is important to identify treatment options to slow or prevent progression to diabetes. It is also critical to assess the potential of medications like sodium glucose transporter 2 inhibitors to reduce the risk of cardiovascular events and kidney complications, both common and costly complications of diabetes. This is a 12-week, open-label pilot feasibility study assessing the use of empagliflozin in prediabetes.
Gender:
ALL
Ages:
Between 35 years and 60 years
Trial Updated:
02/11/2025
Locations: Charles George VA Medical Center, Asheville, North Carolina
Conditions: Prediabetes
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Blood Markers of Early Pancreas Cancer
NCT03568630
Recruiting
Identifying biomarkers of early pancreatic ductal adenocarcinoma (PDAC) could facilitate screening for individuals at higher than average risk and expedite the diagnosis in individuals with symptoms and substantially improve an individual's chance of surviving the disease. The investigators propose a longitudinal study of subjects at higher than average risk of PDAC in order to generate clinical data and bank serial blood specimens.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
02/04/2025
Locations: Unversity of Nebraska Medical Center, Omaha, Nebraska
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Pancreas Cyst, Chronic Pancreatitis, Genetic Predisposition to Disease, Inherited Disease
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Technology-Supported Treatment of Sleep Apnea in Prediabetes
NCT04225507
Recruiting
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular complications in this high-risk population. Sleep apnea is a highly common condition in prediabetes, but it has been mostly ignored and undertreated in current practice. The proposed study will be the first to assess whether adding CPAP (continuous positive air pressure) trea... Read More
Gender:
ALL
Ages:
Between 20 years and 65 years
Trial Updated:
02/04/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Sleep Apnea, PreDiabetes, Overweight or Obesity
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