There are currently 46 active clinical trials seeking participants for Prediabetes research studies. The states with the highest number of trials for Prediabetes participants are Shanghai, California, New York and Florida.
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
NCT06055036
Recruiting
Lower attainment of cardiovascular health (CVH), indicated by the American Heart Association's Life's Simple 7 (LS7; physical activity, diet, cholesterol, blood pressure, body mass index, smoking, glycemia) and Life's Essential 8 (LE8; LS7+sleep) metrics, is a major contributor to Black men having the shortest life-expectancy of any non-indigenous race/sex group. Unfortunately, a paucity of literature exists on interventions aimed at improving CVH among Black men. The team of clinician scientist... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/06/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Cardiometabolic Syndrome, Physical Inactivity, Hypertension, Type 2 Diabetes, PreDiabetes, Obesity, Cardiovascular Diseases, Smoking, Sleep, Hyperlipidemias, Diet, Healthy, Blood Pressure
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Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
NCT06365723
Recruiting
The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs. urban/suburban nature areas/preserves) in adults with prediabetes. The main questions it aims to answer are: * Do psychological measures of stress, anxiety, and affect improve more in one type of outdoor environment over the other? * Do physiological measures of stress improve more in one... Read More
Gender:
ALL
Ages:
Between 25 years and 64 years
Trial Updated:
08/18/2025
Locations: Lake Forest Hospital, Lake Forest, Illinois +1 locations
Conditions: PreDiabetes, Heart Rate Variability (HRV), Stress and Anxiety, Stress Biomarkers
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WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time
NCT06963736
Recruiting
The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact that evening screen time may have on your health.
Gender:
ALL
Ages:
26 years and above
Trial Updated:
08/15/2025
Locations: Arizona State University, Tempe, Arizona
Conditions: Sedentary Time, Cardiovascular Diseases, Prediabetes, Obesity
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Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
NCT07106879
Recruiting
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials. A physician will oversee the informed consent process, after which participants will be surveyed on demographics, medical history, current health conditions and symptoms. The study team may also collect basic health information, including vital signs, urine drug tests, blood samples and pregnancy tests (if applicable). A physician will review... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2025
Locations: Clindove Research LLC, Brooklyn, New York
Conditions: Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes, Mental Health Disorders, Endocrine Dysfunction, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease (CKD)
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Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial
NCT06976307
Recruiting
This is a sub-study to NCT04745572 to include a new cohort of participants with disabilities. This 16-week study will use an experimental approach called the Sequential Multiple Assignment Randomized Trial to help determine which combination and sequence of weight loss program features are most effective in people who are at risk for type 2 diabetes. Participants in the study will be initially randomized to consume either a high or reduced carbohydrate diet. After 4 weeks, participants will be i... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/04/2025
Locations: Wellness Health and Research Facility (WHARF), Birmingham, Alabama
Conditions: Disabilities, Obesity and Overweight, Prediabetes
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CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis
NCT06642610
Recruiting
The primary objective of this pilot study is to develop a CGM-based model to predict the progression from prediabetes to diabetes in individuals with cystic fibrosis.
Gender:
ALL
Ages:
Between 12 years and 55 years
Trial Updated:
07/27/2025
Locations: Indiana University Health, University Hospital, Indianapolis, Indiana
Conditions: Prediabetes, Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes
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Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics
NCT06116149
Recruiting
The primary objective of the STRIVE study is to compare two implementation strategies for Diabetes Prevention Program delivery: an in-person health coach strategy (standard 24 in-person sessions at WIC clinics) vs. a multifaceted technology-assisted health coach implementation strategy (12 in-person sessions at WIC clinics supplemented by technology support) on implementation and health-related outcomes in postpartum women.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
Conditions: Obesity, Gestational Diabetes, Lifestyle, Healthy, Glucose Intolerance During Pregnancy, PreDiabetes, Hyperglycemia
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Role of Insulin Action in Psoriasis Pathogenesis
NCT06242847
Recruiting
The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis. The main question it aims to answer is if insulin action is preserved or even enhanced in psoriatic lesions despite insulin resistance elsewhere. Participants with plaque psoriasis will have punch biopsies taken of lesional and non-lesional skin after an overnight fast and then during an oral glucose tolerance test. Biopsy specimens wi... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/18/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Psoriasis, Plaque Psoriasis, Insulin Resistance, PreDiabetes, Overweight and Obesity
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Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
NCT06025292
Recruiting
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
07/17/2025
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Hyperglycaemia (Non Diabetic), Prediabetes
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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NCT06112418
Recruiting
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/15/2025
Locations: Chandler Clinical Trials, Chandler, Arizona +93 locations
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
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Technology-Supported Treatment of Sleep Apnea in Prediabetes
NCT04225507
Recruiting
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular complications in this high-risk population. Sleep apnea is a highly common condition in prediabetes, but it has been mostly ignored and undertreated in current practice. The proposed study will be the first to assess whether adding CPAP (continuous positive air pressure) trea... Read More
Gender:
ALL
Ages:
Between 20 years and 65 years
Trial Updated:
07/07/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Sleep Apnea, PreDiabetes, Overweight or Obesity
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Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food
NCT06988462
Recruiting
This pilot study aims to explore the potential benefits of consuming Greek Bottarga (grey mullet fish roe) in overweight, pre-diabetic individuals. Before initiating the crossover randomized controlled trial (RCT), the investigators will conduct a preliminary dose-testing study in five overweight and pre-diabetic adults.Participants will undergo clinical assessments before and after the dietary intervention to evaluate changes in metabolic health markers. Following this, the investigators will... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
06/19/2025
Locations: Cambridge Health Alliance, Sommerville, Massachusetts
Conditions: Prediabetes
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