There are currently 22 active clinical trials seeking participants for Substance-Related Disorders research studies. The states with the highest number of trials for Autism participants are California, New York, Washington and Massachusetts.
Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder
Recruiting
This is a randomized, double-blind, placebo-controlled phase 2b pilot clinical trial to determine whether non-ergoline D3/D2/D1 dopamine (DA) receptor agonist rotigotine (RTG), in combination with treatment as usual, including individual or group behavioral therapy can a) reduce cocaine use and also b) increase brain activity in frontocortical areas of the brain, and, as a reflection of that - improve top-down cognitive control in persons with cocaine use disorder (CocUD). Rotigotine is a marke... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/18/2023
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Substance-Related Disorders
Reducing Drug Use in Justice-Involved Emerging Adults
Recruiting
The overarching purpose of this pilot study is to investigate an increasingly common, but under-researched, practice of employing paraprofessional coaches to improve emerging adults' access to and engagement in evidence-based substance use practices, focusing on the paraprofessional coaches' outcomes and the role of lived experience.
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
02/15/2024
Locations: Chestnut Health Systems, Eugene, Oregon
Conditions: Substance-Related Disorders
Treating Stimulant Addiction With Repetitive Transcranial Magnetic Stimulation
Recruiting
The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD). Despite the large public health burden imposed by SUD, there is currently no FDA-approved or widely recognized effective somatic treatment. rTMS may be a promising treatment option for SUD. In this study, we will demonstrate the feasibility of applying rTMS to Veterans with SUD, examine the efficacy of rTMS in the treatment of SUD, and explore bio... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/08/2024
Locations: VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California
Conditions: Stimulant Use Disorder, Substance-related Disorders
Whole Health in VA Mental Health: Omnis Salutis
Recruiting
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use disorders. Difficulties with social relationships and community reintegration are common functional impairments with these disorders. VA is transforming to a Whole Health, patient-centered system of care that will address these issues as part of health care. In a previous study, Omnis Salutis (OS) was developed with Vetera... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/06/2024
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado +1 locations
Conditions: Stress Disorders, Post-Traumatic, Depressive Disorder, Anxiety Disorders, Substance-Related Disorders
Data-driven Identification for Substance Misuse
Recruiting
The investigators propose to develop an open-source, publicly available machine learning model that health systems could download and apply to their electronic health record data marts to screen for substance misuse in their patients. The investigators hypothesize that the natural language processing algorithm can provide a standardized and interoperable approach for an automated daily screen on all hospitalized patients and provide better implementation fidelity for screening, brief interventio... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
01/23/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Substance Use, Substance Abuse, Substance-Related Disorders
Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program
Recruiting
Primary Objective: Conduct a rigorous evaluation of a prevention-based intervention designed to mitigate the harms of adverse childhood experiences (ACEs) exposure and prevent future ACEs, substance use, and overdose within 36 communities experiencing a disproportionate burden of substance use and ACEs. The study has three aims: (1) use a cluster randomized controlled trial to test effectiveness of the Strengthening Families Program (SFP) + Family Advocate (FA) intervention on substance use, ov... Read More
Gender:
All
Ages:
7 years and above
Trial Updated:
01/23/2024
Locations: New Jersey Prevention Network, Tinton Falls, New Jersey
Conditions: Substance-Related Disorders, Adverse Childhood Experiences
Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults
Recruiting
Emerging adults are a particularly vulnerable group for experiencing the immediate and potentially lifelong negative impacts of habitual cannabis use, and trends suggest that cannabis use disorder (CUD) will soon escalate in this population. The proposed research will combine clinical pharmacology, non-invasive brain stimulation, and neuroimaging techniques to establish the brain mechanisms of cannabinoid-impaired decision-making processes in emerging adults with CUD. Results from this project w... Read More
Gender:
All
Ages:
Between 18 years and 34 years
Trial Updated:
11/15/2023
Locations: Neurobehavioral Systems Lab of the University of Kentucky College of Medicine, Lexington, Kentucky
Conditions: Neurosciences, Substance-Related Disorders, Behavior Problem
Impact of Work Activity on SUD Outcomes
Recruiting
To date, there are no studies of the therapeutic effects of varied work-focused programs in Veterans undergoing outpatient substance use disorder (SUD) treatment. The investigators propose a randomized clinical trial to test the effects of work-focused programs on improving sobriety and other clinical outcomes in Veterans early in the course of recovery from SUD. Veterans will be randomized to either receive or not receive referral for work-focused therapeutic programs. Primary aim is to examine... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/09/2023
Locations: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
Conditions: Substance-related Disorders
Wraparound for High-risk Families With Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Recruiting
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously. The intervention participants in one community receive a Wraparound intervention. Comparison group participants drawn from a second matched community receive treatment as usual. With this design, the investigators aim to study outcomes associated with the intervention as well as explore important facilitators and barriers associ... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/06/2023
Locations: Dept of Children Youth and Families, Claremont, New Hampshire +3 locations
Conditions: Substance-Related Disorders, Depression, Stress Disorders, Post-Traumatic, Child Abuse, Child Neglect
Neuroimaging and CBD for Opiod Use Disorder
Recruiting
The investigators propose an imaging study to investigate the neurobiological effects of CBD (vs placebo) in participants with opioid use disorder who are maintained on methadone. The purpose of the study is to determine the neural circuits and transmitters associated with the effects of CBD on to reduce craving and anxiety. The neuroimaging will be conducted in participants immediately following their first administration of CBD (800mg or placebo) and one week after the last administration (3 d... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
09/25/2023
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Heroin Abuse, Opioid Use Disorder, Substance-Related Disorders, Opioid-Related Disorders
Maternal Brain Imaging in Opioid Use Disorder
Recruiting
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved. During pregnancy, people with OUD are prescribed medication-assisted therapy (MAT). The investigators are interested to know how the medication is broken down by the body during pregnancy and how effective it is. The investigators also want to learn if this medication and OUD have any effect on the different parts of the brain when compar... Read More
Gender:
Female
Ages:
Between 18 years and 100 years
Trial Updated:
08/23/2023
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related, Narcotic-Related Disorders, Buprenorphine Dependence
CRP and S&A for Inpatient Veterans
Recruiting
The purpose of this study is to evaluate how well three types of treatments work to improve the outcomes for people with substance use problems. Veterans admitted to the Charleston VA Psychiatric inpatient unit may be invited to participate. The three types of treatments that will be evaluated are: Combined Recovery Program (CRP), a six-session treatment group delivered on the inpatient unit. A Home Telehealth program, called Stable and Able (S&A), provided just prior to discharge and provides... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/11/2023
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Alcoholism, Substance-related Disorders, Dual Diagnosis