There are currently 16 active clinical trials seeking participants for Substance-Related Disorders research studies. The states with the highest number of trials for Substance-Related Disorders participants are California, New York, Washington and Massachusetts.
Impact of Work Activity on SUD Outcomes
Recruiting
To date, there are no studies of the therapeutic effects of varied work-focused programs in Veterans undergoing outpatient substance use disorder (SUD) treatment. The investigators propose a randomized clinical trial to test the effects of work-focused programs on improving sobriety and other clinical outcomes in Veterans early in the course of recovery from SUD. Veterans will be randomized to either receive or not receive referral for work-focused therapeutic programs. Primary aim is to examine... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
Conditions: Substance-related Disorders
Reducing Drug Use in Justice-Involved Emerging Adults
Recruiting
The overarching purpose of this pilot study is to investigate an increasingly common, but under-researched, practice of employing paraprofessional coaches to improve emerging adults' access to and engagement in evidence-based substance use practices, focusing on the paraprofessional coaches' outcomes and the role of lived experience.
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
09/21/2024
Locations: Chestnut Health Systems, Eugene, Oregon
Conditions: Substance-Related Disorders
Mobile Technologies Extending Reach of Primary Care for Substance Use Disorders
Recruiting
The goal of this clinical trial is to evaluate efficacy of our enhanced version of the CHESS Health eIntervention in a clinical setting for those with moderate risk drug or alcohol use and those at high risk or with Substance Use Disorder (SUD) as measured by the ASSIST and the AUDIT assessment tools. The clinical trial is designed to determine whether SBIRT/eIntervention is significantly more effective than SBIRT/Treatment as usual (TAU) as delivered in a primary care setting. While it is not f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: WMed Health Family Medicine, Kalamazoo, Michigan
Conditions: Substance-Related Disorders
Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention
Recruiting
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in an underserved, rural area. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized co... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: University of Maryland Baltimore (UMD Drug Treatment Center), Baltimore, Maryland +2 locations
Conditions: Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders
First Face Training Evaluation in Tribal Communities
Recruiting
The goal of this study is to evaluate a culturally grounded training curriculum, First Face for Mental Health, in Tribal communities, using a waitlist controlled trial design. This curriculum will train Tribal community members in how to respond to youth and adults experiencing mental health crises and serve as a bridge between these individuals and the help they need. The main questions the study aims to answer are: * Does the training increase mental health knowledge, capacity and ability to... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
08/13/2024
Locations: Kootenai Tribe of Idaho, Bonners Ferry, Idaho +8 locations
Conditions: Mental Health, Substance-Related Disorders
Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder
Recruiting
This is a randomized, double-blind, placebo-controlled phase 2b pilot clinical trial to determine whether non-ergoline D3/D2/D1 dopamine (DA) receptor agonist rotigotine (RTG), in combination with treatment as usual, including individual or group behavioral therapy can a) reduce cocaine use and also b) increase brain activity in frontocortical areas of the brain, and, as a reflection of that - improve top-down cognitive control in persons with cocaine use disorder (CocUD). Rotigotine is a marke... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/30/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Substance-Related Disorders
CRP and S&A for Inpatient Veterans
Recruiting
The purpose of this study is to evaluate how well three types of treatments work to improve the outcomes for people with substance use problems. Veterans admitted to the Charleston VA Psychiatric inpatient unit may be invited to participate. The three types of treatments that will be evaluated are: 1. Combined Recovery Program (CRP), a six-session treatment group delivered on the inpatient unit. 2. A Home Telehealth program, called Stable and Able (S\&A), provided just prior to discharge and pr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Alcoholism, Substance-related Disorders, Dual Diagnosis
Motivational Interviewing at Intake vs Intake as Usual on Client Engagement in Addiction Treatment
Recruiting
This K23 study is an effectiveness-implementation hybrid type I design to determine the effectiveness of Motivational Interviewing at Intake (MII), relative to intake-as-usual on client engagement and mechanisms of engagement among adults seeking outpatient addiction treatment. We also will obtain personnel feedback on the feasibility of implementing MII into standard practice by having personnel from the addiction treatment study sites complete implementation climate measures before Motivationa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2024
Locations: Turning Point Recovery Center, Albuquerque, New Mexico
Conditions: Substance-Related Disorders, Treatment Adherence
Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence
Recruiting
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) among low-income, minority individuals living with opioid use disorder (OUD) in Baltimore, Maryland. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this Type 1 hybrid effectiveness-implementation randomized controll... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2024
Locations: University of Maryland Baltimore (UMD Drug Treatment Center), Baltimore, Maryland +1 locations
Conditions: Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use, Opioid Addiction, Treatment Adherence, Retention in Care
Maternal Brain Imaging in Opioid Use Disorder
Recruiting
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved. During pregnancy, people with OUD are prescribed medication-assisted therapy (MAT). The investigators are interested to know how the medication is broken down by the body during pregnancy and how effective it is. The investigators also want to learn if this medication and OUD have any effect on the different parts of the brain when compar... Read More
Gender:
Female
Ages:
Between 18 years and 100 years
Trial Updated:
05/16/2024
Locations: Riley Hospital for Children, Indianapolis, Indiana
Conditions: Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related, Narcotic-Related Disorders, Buprenorphine Dependence
Expression of Stress Markers During Meth Treatment (EXPRESS+)
Recruiting
This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.
Gender:
Male
Ages:
Between 18 years and 45 years
Trial Updated:
05/06/2024
Locations: UCLA Vine Street Clinic, Los Angeles, California
Conditions: Substance-Related Disorders, HIV
Whole Health in VA Mental Health: Omnis Salutis
Recruiting
Recent Veterans of the Afghanistan and Iraq conflicts are presenting in VA care with high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and substance use disorders. Difficulties with social relationships and community reintegration are common functional impairments with these disorders. VA is transforming to a Whole Health, patient-centered system of care that will address these issues as part of health care. In a previous study, Omnis Salutis (OS) was developed with Vetera... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/06/2024
Locations: Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado +1 locations
Conditions: Stress Disorders, Post-Traumatic, Depressive Disorder, Anxiety Disorders, Substance-Related Disorders