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Traumatic Brain Injury Clinical Trials
A listing of 96 Traumatic Brain Injury clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
13 - 24 of 96
There are currently 96 active clinical trials seeking participants for Traumatic Brain Injury research studies. The states with the highest number of trials for Traumatic Brain Injury participants are Texas, California, Florida and Pennsylvania.
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Paid Clinical Studies Nationwide
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Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
TBI Rehabilitation and Activation in Veterans
Recruiting
This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older Veterans with a history of TBI and subjective cognitive complaints will be enrolled and randomly assign to either the TRAIN-Vets intervention (consisting of aquatic-based exercise training, cognitive training, and lifestyle coaching) or the Health Educatio... Read More
Gender:
ALL
Ages:
Between 50 years and 89 years
Trial Updated:
05/14/2025
Locations: VA Palo Alto Health Care System, Palo Alto, California +1 locations
Conditions: Traumatic Brain Injury
Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
Recruiting
TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another level of care. Persons with TBI have heterogenous neurological impairment (cognitive and behavioral foremost, along with motor, sensory, and balance), that limits their functional independence and participation, and increases their risk for secondary medical conditions,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Traumatic Brain Injury
Real Time Vital Sign Assessment to Predict Neurological Decline After Traumatic Brain Injury
Recruiting
This study will look to validate predictive algorithms developed in a previous study where we collected relevant data from trauma registry and after using advanced signal-processing and machine-learning, determined prediction scores regarding neuroworsening and other outcomes following traumatic brain injury.
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
05/12/2025
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Traumatic Brain Injury
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
Recruiting
This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/12/2025
Locations: Florida State University, Tallahassee, Florida
Conditions: Post Traumatic Stress Disorder, Traumatic Brain Injury
Predict Severe Traumatic Brain Injury
Recruiting
Severe traumatic brain injury (TBI) is associated with a 20-30% mortality rate and significant disability among most survivors. The Centers for Disease Control and Prevention (CDC) estimate that 2% of the U.S. population lives with disabilities directly attributable to TBI, with annual costs exceeding $76.5 billion.
Current treatments are largely ineffective because they are instituted after irreversible damage has already occurred. By the time intracranial pressure (ICP) increases or brain tis... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2025
Locations: University of Chicago, Chicago, Illinois +1 locations
Conditions: Traumatic Brain Injury
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
Recruiting
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP pyruvate MRI-derived metrics in TBI patients with healthy subjects as well as Subarachnoid hemorrhage (SAH) patients to better understand if metabolic Magnetic resonance imaging scan (MRI) can improve our ability to diagnos... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/06/2025
Locations: University of Maryland Baltimore, Baltimore, Maryland
Conditions: Traumatic Brain Injury, Subarachnoid Hemorrhage
High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction
Recruiting
The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with neurologic disability. Doctor of Physical Therapy (DPT) students administer the HIM High Intensity Exercise Program. A prior study evaluated the feasibility, safety, and efficacy of the HIM High Intensity Exercise Program and found it feasible, safe, and effective for 30 p... Read More
Gender:
ALL
Ages:
Between 8 years and 99 years
Trial Updated:
04/24/2025
Locations: University of Hartford, West Hartford, Connecticut
Conditions: Cerebral Palsy (CP), Stroke, Spinal Cord Injury, Traumatic Brain Injury, Charcot Marie Tooth Disease (CMT), Spina Bifida
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
Recruiting
The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in patients with moderate to severe traumatic brain injury requiring seizure prophylaxis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Traumatic Brain Injury
University of Colorado - Restoring Efficient Sleep After TBI
Recruiting
Sleep disturbance is a common condition following traumatic brain injury (TBI) and impairs recovery and quality of life. While efficacious interventions exist many are not accessible to all patients due to a variety of factors (e.g., rurality, access to providers). Further, many of the available treatments have not been validated for individuals with moderate/severe TBI. The proposed study will evaluate a guided computerized version of cognitive behavioral therapy for insomnia (cCBT-I) against e... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/17/2025
Locations: Rocky Mountain Regional VAMC, Aurora, Colorado
Conditions: Insomnia, Traumatic Brain Injury
Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).
Recruiting
The main goal of this clinical trial is to check if the treatment is safe and well-tolerated. Researchers will compare the MR-301 active drug group with the placebo group to evaluate the safety and tolerability of the drug. Other measurements include assessing the patient's overall outcome, neurological responses, time spent in the intensive care unit, time in the hospital, and mortality. Participants will receive either MR-301 BID IV dosing or a matching placebo for a total of 3 weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/16/2025
Locations: Los Angeles General Medical Center, Los Angeles, California +11 locations
Conditions: Traumatic Brain Injury
Community-based Implementation of Online EmReg
Recruiting
This is a hybrid type III implementation-effectiveness trial; this study design blends elements of implementation and clinical effectiveness research, with the primary aim of determining the utility of an implementation strategy and a secondary aim of assessing clinical outcomes associated with the implementation trial. Consistent with best practices for this type of design, the study team will conduct a randomized test of the effect of implementation strategy on effective delivery of the Online... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Traumatic Brain Injury, Emotion Regulation
Non-invasive BCI-controlled Assistive Devices
Recruiting
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement without actually performing it. Brain-computer interfaces (BCIs) can decode SMRs to control assistive devices and promote functional recovery. Despite rapid advancements in non-invasive BCI systems ba... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/28/2025
Locations: The University of Texas at Austin, Austin, Texas
Conditions: Motor Disorders, Healthy, Spinal Cord Injuries, Muscular Diseases, Motor Neuron Disease, Stroke, Traumatic Brain Injury, Movement Disorders, Multiple Sclerosis
13 - 24 of 96