Delaware is currently home to 277 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Newark, Wilmington, Lewes and Rehoboth Beach. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors
NCT05270213
Recruiting
RBS2418 (investigational product) is a specific immune modulator, working through ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1), designed to lead to anti-tumor immunity by increasing endogenous 2'-3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) and adenosine triphosphate (ATP levels) and reducing adenosine production in the tumors. RBS2418 has the potential to be an important therapeutic option for subjects both as monotherapy and in combination with checkpoint blo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Christiana Care Health Services, Newark, Delaware
Conditions: Advanced Cancer
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Effects of Acute Pain on Motor Learning in Young vs Older Adults
NCT05471557
Recruiting
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its retention in older adults. The investigators hypothesize that acute pain impairs retention of locomotor learning in young and older adults and that in older adults, these deficits are worsened and are related to the degree of normal age-related cognitive decline.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/25/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Aging, Pain, Acute, Cognitive Decline, Motor Activity
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Promoting Independence With Compensatory Cognitive Rehabilitation
NCT04820335
Recruiting
Alzheimer's disease (AD) is one of the leading causes of disability in older adults. Because pharmacological approaches do not seem to prevent or slow the disease, clinicians need non-pharmacological interventions that might help people with AD remain independent for as long as possible. This study aims to evaluate the effects of a new behavioral treatment, the Structured External Memory Aid Treatment (SEMAT), for adults with mild cognitive impairment (MCI) designed to promote independent living... Read More
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
11/19/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Mild Cognitive Impairment, Alzheimer Disease
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Non-Invasive Measurement of Pulmonary Dysfunction in Children with Cerebral Palsy
NCT05791877
Recruiting
This proposal addresses pulmonary dysfunction in severe cerebral palsy by using a novel non-invasive respiratory sensor. The two aims of the project are to 1) provide a screening tool to detect respiratory distress and 2) Find a correlation between the degree of pulmonary dysfunction and scoliosis in children with cerebral palsy.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
11/18/2024
Locations: Nemours Children's Hospital, Wilmington, Delaware
Conditions: Cerebral Palsy
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Non-Invasive Respiratory Monitor
NCT02851043
Recruiting
This study will clinically evaluate a newly developed respiratory monitor - pneuRIP. The pneuRIP uses Respiratory Inductance Plethysmography (RIP) bands to measure key breathing indices non-invasively. This study compares the pneuRIP to an existing Respitrace system (Carefusion, Yorba Linda CA). 10 normal children and 10 children with breathing difficulties will be monitored with both systems.
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
11/18/2024
Locations: Nemours/A.I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Neuromuscular Diseases, Healthy Volunteers
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Resveratrol for the Prevention of Bone Loss in Postmenopausal Women
NCT06250283
Recruiting
The purpose of this study is to examine whether daily supplementation of resveratrol would improve bone health in postmenopausal women.
Gender:
FEMALE
Ages:
All
Trial Updated:
11/13/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Low Bone Mass
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Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
NCT05112237
Recruiting
The objective of this study is to collect information on patients with cardiomyopathy (CM) due to mutations in the MYBPC3 gene, to evaluate their disease course, burden of illness, risk factors for this disease, and the quality of life (QoL). This study will also collect information on treatments, procedures and outcome in infants and children up to 18 yrs who have this mutation.
Gender:
ALL
Ages:
Between 0 years and 18 years
Trial Updated:
11/11/2024
Locations: Nemours Alfred I. Dupont Hospital for Children, Wilmington, Delaware
Conditions: Cardiomyopathy
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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768
Recruiting
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be bette... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Beebe South Coastal Health Campus, Frankford, Delaware
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
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Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials
NCT05108298
Recruiting
The purpose of this study is to evaluate feasibility and acceptability of completing PROs among AYAs randomized to Choice PRO vs Fixed PRO.
Gender:
ALL
Ages:
Between 18 years and 39 years
Trial Updated:
10/28/2024
Locations: Beebe South Coastal Health Campus, Frankford, Delaware
Conditions: Breast Cancer, NOS, CNS Primary Tumor, NOS, Cervical Cancer, NOS, Colorectal Cancer, NOS, Leukemia, NOS, Lymphoma, NOS, Miscellaneous Neoplasm, NOS, Non-Rhabdomyosarcoma Soft Tissue Sarcoma, NOS, Testicular Nonseminomatous Germ Cell Tumor, NOS, Thyroid Cancer, NOS, Melanoma, Bone Cancer, NOS
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Oxytocin Rest to Reduce Cesarean Delivery
NCT06268431
Recruiting
Prolonged labor is usually managed with continuous oxytocin infusion. "Oxytocin rest" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. "Oxytocin rest" is performed on labor and delivery units across the Unit... Read More
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
10/15/2024
Locations: ChristianaCare Health System, Newark, Delaware
Conditions: Prolonged Labor, Failed Induction, Labor Dystocia
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Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
NCT04065438
Recruiting
This multicenter, prospective, single-arm clinical study will evaluate the probable benefit and safety of the LIPOSORBER® LA-15 System for the treatment of adult patients with nephrotic syndrome associated with primary focal segmental glomerulosclerosis, when the standard treatment options, including corticosteroid and/or calcineurin inhibitors treatments, have been unsuccessful or not well tolerated, and the patient has a GFR ≥ 45 ml/min/1.73m2, or the patient has post-renal transplant recurren... Read More
Gender:
ALL
Ages:
75 years and below
Trial Updated:
10/07/2024
Locations: Nemours/Alfred I DuPont Hospital for Children, Wilmington, Delaware
Conditions: Focal Segmental Glomerulosclerosis
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Primordial Dwarfism Registry
NCT04569149
Recruiting
The goal of this registry is to collect information on individuals with forms of microcephalic primordial dwarfism. The study team hopes to learn more about these conditions and improve the care of people with it by establishing this registry.
Gender:
ALL
Ages:
All
Trial Updated:
09/26/2024
Locations: Nemours, Wilmington, Delaware
Conditions: MOPDII, Meier-Gorlin Syndrome, Saul-Wilson Syndrome, Ligase 4 Syndrome, Microcephalic Primordial Dwarfism, RNU4atac-opathy (e.g. MOPDI/III, Lowry-Wood Syndrome, Roifman Syndrome)
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