Delaware is currently home to 302 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Newark, Wilmington, Lewes and Rehoboth Beach. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Impact of Estradiol on Endothelial Function in Peri-Menopausal Women
NCT04255160
Recruiting
The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.
Gender:
Female
Ages:
Between 40 years and 58 years
Trial Updated:
05/10/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Perimenopause, Vasodilation, Estrogen
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Exercise and Motor Learning After Stroke (Study #3)
NCT03726047
Recruiting
Subjects with chronic stroke (> 6 months post-stroke) will learn a new walking pattern through distorted visual feedback. Retention of the pattern will be tested without visual feedback immediately after learning and 24 hours later. Subjects will be randomly assigned to the control group or the exercise group. The control group will simply complete the learning task. The exercise group will complete 5 minutes of exercise immediately following the first retention test to test for the effects of e... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
05/08/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Stroke
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Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors
NCT04315883
Recruiting
This study will be performed to evaluate the Clinical Outcomes and Quality of Life after Transarterial Radioembolization with Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults with Liver Tumors. The treatment and techniques used here are well established in adults. The purpose of this study is to evaluate: the response to treatment and clinical outcomes of treatment with TARE Y-90 as part of standard therapy and to assess the change in the patient's quality of life before, durin... Read More
Gender:
All
Ages:
Between 0 years and 21 years
Trial Updated:
05/01/2023
Locations: Nemours-AI duPont Hospital for Children, Wilmington, Delaware
Conditions: Hepatoblastoma, Hepatocellular Carcinoma, Rhabdoid Tumor of Liver, Undifferentiated (Embryonal) Sarcoma of the Liver, Pediatric Liver Cancer, Liver Tumors
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Aging Brain Structure and Memory in Response to Exercise
NCT03855475
Recruiting
This study will measure brain structure through its mechanical properties, assessed with magnetic resonance elastography, and determine whether it improves with aerobic exercise in older adults with low memory abilities. Additionally, this study will determine if memory abilities improve with exercise and if they are related to brain structure. Overall, this project has the potential to identify how brain health is impacted by exercise in older adults.
Gender:
All
Ages:
Between 60 years and 90 years
Trial Updated:
04/19/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Mild Cognitive Impairment
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NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
NCT04798378
Recruiting
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one arm sufficient to perform daily activities. This study could lead to the development of a product that could allow people with arm weakness or arm paralysis to use the NuroSleeve and similar devices to improve arm health and independent function.
Gender:
All
Ages:
4 years and above
Trial Updated:
04/11/2023
Locations: Nemours Children's Hospital, Wilmington, Delaware
Conditions: Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies, Arthrogryposis, Spinal Cord Injuries, Charcot-Marie-Tooth, Stroke, Weakness of Extremities as Sequela of Stroke, Weakness Due to Upper Motor Neuron Dysfunction, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, Arm Paralysis, Cerebral Palsy
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Intervening With Opioid-Dependent MothersMothers and Infants
NCT04454645
Recruiting
This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up (mABC) Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment for opioid use disorder. The investigators expect that mothers who receive the modified Attachment and Biobehavioral Catch-up Intervention will show more nurturing and sensitive parenting and more adaptive physiological regulation than parents who receive a control intervention. The investigators expect that... Read More
Gender:
Female
Ages:
Between 18 years and 70 years
Trial Updated:
03/09/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Opioid Dependence, Parenting, Infant Development
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Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
NCT04065438
Recruiting
This multicenter, prospective, single-arm clinical study will evaluate the probable benefit and safety of the LIPOSORBER® LA-15 System for the treatment of adult patients with nephrotic syndrome associated with primary focal segmental glomerulosclerosis, when the standard treatment options, including corticosteroid and/or calcineurin inhibitors treatments, have been unsuccessful or not well tolerated, and the patient has a GFR ≥ 45 ml/min/1.73m2, or the patient has post-renal transplant recurren... Read More
Gender:
All
Ages:
75 years and below
Trial Updated:
03/09/2023
Locations: Nemours/Alfred I DuPont Hospital for Children, Wilmington, Delaware
Conditions: Focal Segmental Glomerulosclerosis
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Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children
NCT02235857
Recruiting
Liposorber® LA-15 System is a blood purification therapy that selectively removes malignant lipoproteins including low density lipoprotein from circulating blood flow and rapidly reduces the plasma cholesterol level. The system was originally developed for the treatment of patients with serious dyslipidemia such as familial hypercholesterolemia and then applied to improve the dyslipidemia, a common complication of nephrotic syndrome and found to bring about improvement not only with the dyslipid... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
03/07/2023
Locations: Nemours/A.I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Focal Segmental Glomerulosclerosis
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Assessing the Clinical Benefit of Molecular Profiling in Patients With Solid Tumors
NCT03061305
Recruiting
Many patients are treated for advanced cancer without knowledge of underlying molecular features that might indicate FDA approved therapies or potential eligibility for biomarker-selected clinical trials. The Strata Trial (STR-001-001) has been initiated by Strata Oncology to evaluate the clinical benefit of systematic comprehensive genomic profiling for participants with advanced cancer using real-world data and endpoints, while assessing the proportion of participants available for clinical t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2023
Locations: Christiana Care Health System, Newark, Delaware
Conditions: Cancer, Adult Solid Tumor, Lymphoma, Multiple Myeloma
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First Complementary Foods and the Infant Gastrointestinal Microbiota
NCT05492253
Recruiting
This study evaluates the effect of different complementary foods on the gastrointestinal microbiota of exclusively human milk fed infants.
Gender:
All
Ages:
Between 5 months and 7 months
Trial Updated:
02/14/2023
Locations: University of Delaware, Newark, Delaware
Conditions: Healthy Participants, Infants, Gastrointestinal Microbiota
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Study of Infigratinib in Children With Achondroplasia
NCT04265651
Recruiting
This is a Phase 2, multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, and efficacy of infigratinib, a fibroblast growth factor receptor (FGFR) 1-3-selective tyrosine kinase inhibitor, in children 3 to 11 years of age with Achondroplasia (ACH) who previously participated in the PROPEL study (Protocol QBGJ398-001) for at least 6 months. The study includes dose escalation with extended treatment, and dose expansion. The study also includes a PK S... Read More
Gender:
All
Ages:
Between 3 years and 11 years
Trial Updated:
02/06/2023
Locations: Nemours Alfred I. Dupont Hospital for Children, Wilmington, Delaware
Conditions: Achondroplasia
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Apixaban for the Acute Treatment of Venous Thromboembolism in Children
NCT02464969
Recruiting
To assess the safety and descriptive efficacy of apixaban in pediatric subjects requiring anticoagulation for the treatment of a VTE.
Gender:
All
Ages:
Between 0 days and 17 years
Trial Updated:
02/06/2023
Locations: Nemours/ Alfred I. duPont Hospital for Children, Wilmington, Delaware
Conditions: Venous Thromboembolism
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