There are currently 816 clinical trials in Washington, District Of Columbia looking for participants to engage in research studies. Trials are conducted at various facilities, including Children's National Medical Center, Medstar Georgetown University Hospital, MedStar Washington Hospital Center and Walter Reed Army Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
Register for Updates
Orphan Europe Carbaglu® Surveillance Protocol
NCT03409003
Recruiting
The purpose of this study is to conduct post-marketing surveillance of carglumic acid (Carbaglu) to obtain long-term clinical safety information. Carglumic acid was approved by the United States Food and Drug Administration (FDA) for treatment of acute hyperammonemia due to N-acetylglutamate synthase (NAGS) deficiency. Much of the FDA-required data is already collected through the Longitudinal Study of Urea Cycle Disorders (RDCRN Protocol #5101). This study will collect additional data on advers... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/06/2024
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: N-acetylglutamate Synthase (NAGS) Deficiency
Register for Updates
Systemic Biomarkers of Brain Injury From Hyperammonemia
NCT04602325
Recruiting
Ammonia is a waste product of protein and amino acid catabolism and is also a potent neurotoxin. High blood ammonia levels on the brain can manifest as cytotoxic brain edema and vascular compromise leading to intellectual and developmental disabilities. The following aims are proposed: Aim 1 of this study will be to determine the chronology of biomarkers of brain injury in response to a hyperammonemic (HA) brain insult in patients with an inherited hyperammonemic disorder. Aim 2 will be to det... Read More
Gender:
ALL
Ages:
Between 7 years and 18 years
Trial Updated:
02/06/2024
Locations: Children's National Research Institute, Washington, District of Columbia
Conditions: Urea Cycle Disorder, Organic Acidemia, Maple Syrup Urine Disease, Glutaric Acidemia I, Fatty Acid Oxidation Disorder, Hypoxic-Ischemic Encephalopathy
Register for Updates
MuSK Myasthenia 1000 Study
NCT06259071
Recruiting
The MuSK myasthenia gravis 1000 study seeks to collect saliva samples from 1000 subjects with laboratory confirmed diagnosis of MuSK myasthenia to identify genetic variations associated with MuSK MG. The data collected may be used by researchers to gain a better understanding of the cause of MuSK MG and to identify biomarkers and targeted therapy for MuSK MG.
Gender:
ALL
Ages:
Between 7 years and 99 years
Trial Updated:
02/06/2024
Locations: George Washington University, Washington, District of Columbia
Conditions: Myasthenia Gravis, MuSK MG, MuSK Myasthenia Gravis
Register for Updates
Acute Concussion and Melatonin
NCT04731974
Recruiting
In this study, the investigator plans a randomized trial of melatonin versus placebo post acute pediatric concussion. The investigator hypothesizes that patients with acute concussions managed with melatonin will have improved sleep, decreased depressive symptoms, decreased risk of prolonged concussion symptoms and faster resolution of concussion symptoms.
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
02/05/2024
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Concussion, Mild, Concussion, Brain, Pediatric ALL
Register for Updates
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
NCT05338697
Recruiting
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: MedStar Washington Hospital Center, Washington, District of Columbia
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
Register for Updates
A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
NCT04775485
Recruiting
FIREFLY-1 is an ongoing, Phase 2, multi center, open-label study to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with recurrent or progressive low-grade glioma or an advanced solid tumor harboring a known RAF alteration.
Gender:
ALL
Ages:
Between 6 months and 25 years
Trial Updated:
12/21/2023
Locations: Children's National Medical Center, Washington, District of Columbia
Conditions: Low-grade Glioma, Advanced Solid Tumor
Register for Updates
Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
NCT05865041
Recruiting
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2023
Locations: 1 Site, Washington, District of Columbia
Conditions: Alopecia Areata
Register for Updates
Evaluating the Many Ways of Being Program
NCT05801601
Recruiting
The goal of this randomized control trial is to clinical trial is to evaluate Many Ways of Being, an innovative sexual health promotion program focused on addressing rigid gender norms and promoting healthy relationships. The overall goal of the MWB program is to reduce incidence of sexually transmitted infections (STI) and unplanned pregnancy and promote healthy, consensual, and violence-free relationships among youth. The primary research question we aim to answer through this study is: Among... Read More
Gender:
ALL
Ages:
Between 15 years and 19 years
Trial Updated:
11/17/2023
Locations: LAYC's Teen Center, Washington, District of Columbia
Conditions: Sexual Behavior, Unprotected Sex
Register for Updates
Digital Media for Cancer Control (to Prevent Vaping and Smoking Behavior)
NCT04867668
Recruiting
There is little published data on exposure to and evaluations of large-scale, online tobacco control campaigns. This project addresses the gap. Under 2 specific aims, the investigators will identify the independent effects of varying levels of digital message exposure to promote anti-tobacco attitudes, beliefs, or behaviors among youth and young adults, first through a randomized experiment online, and second through a field-based evaluation. These studies will advance the science of digital hea... Read More
Gender:
ALL
Ages:
Between 18 years and 24 years
Trial Updated:
11/16/2023
Locations: The George Washington University Milken Institute School of Public Health, Washington, District of Columbia
Conditions: Tobacco Use
Register for Updates
A Prospective Analysis of Long-Term Clinical Outcomes and 3D Spine Growth in Anterior Vertebral Body Tethering
NCT04914507
Recruiting
Anterior vertebral body tethering (AVBT) is a novel, minimally invasive, growth modulation technique that was recently approved by the FDA under a Humanitarian Device Exemption (HDE). The goal of AVBT is to control curve progression by applying compression on the convex side of the spine deformity. While there has been great initial enthusiasm about the technique as an alternate treatment option to spinal fusion for skeletally immature children with scoliosis, there is a need to better understan... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
11/14/2023
Locations: Children's National Hospital, Washington, District of Columbia
Conditions: Scoliosis Idiopathic
Register for Updates
Intraperitoneal Infusion of Analgesic for Postoperative Pain Management
NCT04130464
Recruiting
The study is a prospective, double-blinded, placebo-controlled multi-center trial to measure if postoperative pain and the amount of narcotics used are reduced by a clinically significant amount in women undergoing minimally invasive hysterectomy receiving a continuous infusion of intraperitoneal (IP) local anesthetic (LA) or a continuous infusion of LA combined with an NSAID compared with a control group who receives only 0.9% normal saline.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
11/06/2023
Locations: MedStar Washington Hospital Center, Washington, District of Columbia +1 locations
Conditions: Hysterectomy, Gynecologic Surgical Procedures, Narcotic Use, Pain, Postoperative
Register for Updates