There are currently 85 clinical trials in Weston, Florida looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic Florida, Cleveland Clinic-Weston, Cleveland Clinic Florida - Weston and Cleveland Clinic. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)
Recruiting
This study is designed to assess the safety and efficacy of lenvatinib in combination with pembrolizumab versus standard of care (SOC) chemotherapy, and to also assess the safety and efficacy of lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and a programmed cell death protein 1 (PD-1) or anti-programmed death ligand 1 (PD-L1) inhibitor. The primary hypothesis is that lenvatinib + pemb... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Cleveland Clinic Florida ( Site 1596), Weston, Florida
Conditions: Squamous Cell Carcinoma of Head and Neck
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
Recruiting
This is a Phase III, multicenter, randomized, open-label, global study designed to evaluate the efficacy and safety of inavolisib plus fulvestrant compared with alpelisib plus fulvestrant in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2) -negative, PIK3CA-mutated, locally advanced (LA) or metastatic breast cancer (mBC), who progressed during or after cyclin dependent kinase 4/6i (CDK4/6i)-based therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Breast Cancer
MILDĀ® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Recruiting
This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure. This study will start with patients treated with a study procedure having an index date on or after January 1, 2017, and enrollment will continue until stopped by... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Cleveland Clinic of Weston, Weston, Florida
Conditions: Lumbar Spinal Stenosis
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema
Recruiting
Phase 2 study to compare INBRX-101 to plasma derived A1PI therapy in adults with AATD emphysema
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/23/2024
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Alpha 1-Antitrypsin Deficiency, Emphysema
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
Recruiting
The purpose of this study is to demonstrate superiority of macitentan 75 milligrams (mg) in prolonging the time to the first clinical events committee (CEC)-adjudicated morbidity or mortality (M/M) event in participants with symptomatic pulmonary arterial hypertension (PAH) compared to macitentan 10 mg.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Cleveland Clinic, Weston, Florida
Conditions: Pulmonary Arterial Hypertension
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Recruiting
This phase II/III trial compares the effect of adding radiation therapy to the usual maintenance therapy with atezolizumab versus atezolizumab alone in patients who have already received atezolizumab plus chemotherapy for the treatment of small cell lung cancer that has spread outside of the lung or to other parts of the body (extensive stage). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability o... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Cleveland Clinic-Weston, Weston, Florida
Conditions: Extensive Stage Lung Small Cell Carcinoma
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
Recruiting
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Colorectal Neoplasms
A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma
Recruiting
The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Relapsed or Refractory Multiple Myeloma
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
Recruiting
This study will evaluate the efficacy and safety of astegolimab compared with placebo in participants with chronic obstructive pulmonary disease (COPD) who are former or current smokers and have a history of frequent exacerbations.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
04/23/2024
Locations: Cleveland Clinic Florida, Weston, Florida
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
Recruiting
The primary objective of this study is to assess the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the composite endpoint of all-cause mortality (ACM) and total cardiovascular (CV) clinical events.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
04/23/2024
Locations: Research Site, Weston, Florida
Conditions: Transthyretin Amyloid Cardiomyopathy
Individualized Treatments in Adults With Relapsed/Refractory Cancers
Recruiting
A personalized cancer medicine approach would address therapy resistance, cancer metastasis, and limited options after standard of care is exhausted in advanced cancer participants. This approach may reduce the barriers to approved therapeutic assignment currently limited to a particular cancer type or patient demographic.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2024
Locations: Lerner College of Medicine, Cleveland Clinic Florida, Weston, Florida
Conditions: Refractory Cancer, Relapsed Cancer
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
Recruiting
The objectives of this registry study are to evaluate real-world clinical outcomes and patient reported outcomes that measure the effectiveness and safety of STaRT.
Gender:
All
Ages:
All
Trial Updated:
04/22/2024
Locations: Cleveland Clinic Florida- Weston, Weston, Florida
Conditions: Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary, Brain Tumor - Metastatic, Brain Tumor, Adult: Glioblastoma, Brain Tumor, Adult Meningioma