There are currently 585 clinical trials in Louisville, Kentucky looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Louisville, Jewish Hospital, Norton Cancer Institute and Norton Children's Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of Enterra Programming with Nocturnal Cycling in Gastroparetics
NCT05980455
Recruiting
The purpose of this research study is to evaluate if different Enterra® device programming methods active during sleeping hours can maintain gastroparesis-related symptom relief and quality of life measures. Participants in this study with existing Enterra® devices will be randomly assigned to one of three programming methods that will be active during sleep. Participants will answer daily questions about their gastroparesis symptoms on an application with their phone/tablet. Participants will... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/13/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
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Study of Enhanced Programming Stimulation with the Enterra® Therapy System
NCT06560307
Recruiting
The purpose of this research study is to evaluate if an enhanced Enterra device programming strategy will improve symptoms associated with gastroparesis, improve symptoms in a faster amount of time, and improve quality of life measures. Participants in this study will be evaluated for study entry criteria, have an Enterra Therapy System implanted, and be randomly assigned to one of two programming strategies. Participants will answer daily questions about their gastroparesis symptoms on an appl... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
11/13/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
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Comparative Effectiveness of Online 8-session CBT Vs. 1-Session Empowered Relief for Chronic Pain - the PROGRESS Study
NCT05612750
Recruiting
The purpose of this study is to conduct a pragmatic clinical trial comparing the effectiveness of: (1) 8-week cognitive behavioral therapy for chronic pain (pain-CBT; sixteen hours total treatment time); and (2) a 1-session pain relief skills intervention for chronic pain (Empowered Relief; two hours total treatment time).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Humana, Louisville, Kentucky
Conditions: Pain, Chronic, Lupus, Pelvic Pain
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Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier
NCT06426628
Recruiting
The goal of this observational study is to learn how a physician uses the results of the Percepta® Nasal Swab test to manage people with a newly identified pulmonary nodule. The main questions it aims to answer are: * Does the use of the Percepta Nasal swab test reduce the number of invasive procedures in people with a low-risk result and whose nodule is benign? * Does the use of the Percepta Nasal swab test decrease the time to treatment in people with a high-risk result and whose nodule is c... Read More
Gender:
ALL
Ages:
Between 29 years and 85 years
Trial Updated:
11/12/2024
Locations: Robley Rex VA Medical Center, Louisville, Kentucky
Conditions: Pulmonary Nodule, Solitary, Lung Cancer
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A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for Anastomotic Leaks Detection
NCT06168669
Recruiting
Purpose: To validate the safety and effectiveness of xBar monitoring tool for detection of post-operative anastomotic leaks in subjects undergoing rectal/sigmoid resections with anastomosis. The clinical team is blinded to the leak detection of the xBar system.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
11/03/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Colorectal Surgery, Anastomotic Leak
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Single or Repeated Intravenous Administration of umbiliCAl Cord Mesenchymal sTrOmal Cells in Ischemic Cardiomyopathy
NCT06145035
Recruiting
This is a Phase IIA, randomized, double blind, placebo controlled, multicenter study designed to assess the safety, feasibility, and efficacy of umbilical cord derived mesenchymal stromal cells (UC MSCs), administered intravenously (IV) as a single dose or repeated doses, in patients with ischemic cardiomyopathy (ICM).
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
10/23/2024
Locations: University of Louisville School of Medicine, Institute of Molecular Cardiology, Louisville, Kentucky
Conditions: Ischemic Heart Disease
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Administration of Allogeneic-MSC in Patients with Non-Ischemic Dilated Cardiomyopathy
NCT04476901
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called human allogeneic mesenchymal stem cell therapy.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/21/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Non-ischemic Dilated Cardiomyopathy
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Harm Reduction for Smokers With Mental Illness
NCT06543407
Recruiting
To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation treatment, and to examine self-regulation (using e-cigs instead of cigarettes to cope with stress/distress and self-efficacy) as a potential mechanism for behavior change from SWITCH IT
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/15/2024
Locations: Seven Counties Services, Louisville, Kentucky
Conditions: Tobacco Dependence
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Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX)
NCT05838248
Recruiting
This prospective trial will randomize patients who have had an appendectomy to two different durations of antibiotic therapy depending on the status of the appendicitis. For simple appendicitis, patients will be randomized to peri-operative antibiotics or 24 hours duration. For complex appendicitis, patients will be randomized to 24 hours or 4 days duration. Data will be collected prospectively and test the hypothesis that shorter durations of antibiotics will be non-inferior to the longer durat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2024
Locations: Jewish Hospital UL, Louisville, Kentucky +1 locations
Conditions: Appendicitis
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Encouraging a Plant Based Diet in an Underserved Urban Population
NCT06090409
Recruiting
The investigator's goal is to promote a plant-based diet amongst the underserved urban population of Louisville with the help of educational aids and the provision of affordable resources.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2024
Locations: University of Louisville Ambulatory Internal Medicine Resident Clinic, Louisville, Kentucky
Conditions: Food Neophobia, Food Preferences, Dietary Habits
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Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies
NCT04561362
Recruiting
This study is a Phase I/II, multicenter, first-in-human, open-label dose-escalation study of BT8009 given as a single agent and in combination with pembrolizumab in participants with advanced solid tumors associated with Nectin-4 expression or in participants with advanced solid tumor malignancies having renal insufficiency. The primary endpoints are: Dose limiting toxicities (Parts A-1 and A-2), Overall response rate per RECIST v1.1 (Parts B1-B7), Safety and tolerability (Parts B-8, B-9 and C),... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Norton Cancer Institute, Downtown, Louisville, Kentucky
Conditions: Advanced Solid Tumor, Urinary Bladder Neoplasm, Triple Negative Breast Neoplasms, Ovarian Neoplasm, Hormone Receptor Positive, HER2-negative Neoplasms, Hormone Receptor Positive, HER2-low Neoplasms, Breast Neoplasms, Non-Small-Cell Lung Neoplasms
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Intermediate Visual Space Perception
NCT05419713
Recruiting
The ability to judge the locations of various objects from oneself during self-motion in the intermediate distance range (\~2-25m) is crucial for successful performance of activities of daily living, such as walking and driving. However, little is known about the mechanisms of visual space perception involved in judging distance, the focus of this project, in the planning and/or execution of self-motion in the natural 3D environment. The theoretical knowledge to be gained from this project will... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
09/23/2024
Locations: University of Louisville, Louisville, Kentucky
Conditions: Vision
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