There are currently 632 clinical trials in Louisville, Kentucky looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Louisville, Jewish Hospital, Norton Cancer Institute and Saints Mary and Elizabeth Hospital. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue
NCT01294072
Recruiting
This clinical trial will investigate the ability of plant exosomes to more effectively deliver curcumin to normal colon tissue and colon tumors. Curcumin is the yellow pigment of turmeric, a natural product with diverse biological activities. Exosomes are small endosome-derived vesicles (50-100 nanometers [nm] in size). Previous clinical trials conducted with oral curcumin have demonstrated only limited bioavailability even at very high doses of 8-12 grams per day. This trial plans to address th... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
12/14/2023
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Colon Cancer
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Task-specific Epidural Stimulation Study
NCT03364660
Recruiting
The investigators propose to understand the role of lumbosacral spinal cord epidural stimulation (scES) in recovery of autonomic nervous system function, voluntary movement, and standing in individuals with severe spinal cord injury (SCI). Thirty-six individuals with severe SCI who have cardiovascular and respiratory dysfunction and who are unable to voluntarily move the legs or stand will receive scES for cardiovascular function, voluntary movement, or standing with and/or without weight-bearin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/14/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Spinal Cord Injuries
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Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
NCT05865041
Recruiting
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/12/2023
Locations: 1 Site, Louisville, Kentucky
Conditions: Alopecia Areata
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Study of the Efficacy and Safety of NST-1024 Versus Placebo in Subjects With Hypertriglyceridemia
NCT05889156
Recruiting
This is a Phase IIa,multicentre proof of concept study consisting of 2 study periods to study Treatment with NST-1024 as an adjunct to diet to reduce triglyceride (TG) levels in subjects with TG levels of ≥500 mg/dL and ≤2000 mg/dL; determined by percentage change in TG from baseline after 28 days of treatment. The two periods consist of: A 3-week screening period that includes a TG qualifying period, and A 28-days, double-blind, randomized, parallel group, placebo-controlled treatment period.... Read More
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
12/12/2023
Locations: University of Louisville - UoL Physicians Outpatient Center, Louisville, Kentucky
Conditions: High Triglycerides
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Comparison Using a VLS Using GlideRite Stylet Versus TCI Articulating Introducer in Predictive Difficult Intubation
NCT04866472
Recruiting
This study will assess the feasibility of using the TCI Articulating Device with video-laryngoscope in predictive, difficult airway, endotracheal intubation cases. It is meant to show the use of this device is equivalent to using the GlideRite Rigid Stylet with video-laryngoscope.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/08/2023
Locations: University of Louisville School of Medicine, Louisville, Kentucky +1 locations
Conditions: Predicted Difficult Airway
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Recovery and Outcomes From Stroke
NCT04007757
Recruiting
The investigators will perform follow-up on 500 cases of deep and lobar intracerebral hemorrhage to perform advanced neuroimaging before 45 days post stroke, and evaluations of motor and cognitive function at baseline, 3 months and 6 months to determine predictors of recovery, progressive cognitive or functional impairment.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/06/2023
Locations: Baptist Health Louisville, Louisville, Kentucky
Conditions: Intracerebral Hemorrhage
Register for Updates
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
NCT05688280
Recruiting
The goal of this clinical trial is to determine the safety and efficacy of IP-001 for intratumoral injection administration following thermal ablation of a solid tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: University of Louisville Physicians, PSC, Louisville, Kentucky
Conditions: Metastatic Solid Tumor, Colon Cancer, Nonsmall Cell Lung Cancer, Soft Tissue Sarcoma
Register for Updates
Safety and Effectiveness Study of OR3O™ Dual Mobility System in THA
NCT04325022
Recruiting
The purpose of this study is to assess the safety and effectiveness of the OR3O™ Dual Mobility System. The study will evaluate the outcome of the Total Hip Arthroplasty using the OR3O™ Dual Mobility System over a ten year period. Survivorship of THA will be assessed up to ten years.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
12/01/2023
Locations: Louisville Orthopaedic Clinic, Louisville, Kentucky
Conditions: Advanced Degeneration of the Hip Joint, Revision of the Hip Joint
Register for Updates
Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
All
Ages:
Between 1 year and 120 years
Trial Updated:
11/30/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
Register for Updates
Health, Environment and Action in Louisville (HEAL) Green Heart Louisville Project
NCT03670524
Recruiting
The purpose of this study is to examine how the environment and neighborhood characteristics affects the health of the area residents. The study will help determine how changing neighborhood characteristics, such as green space, affect heart health, risk factors for other diseases, sense of well- being or neighborhood cohesion.
Gender:
All
Ages:
Between 30 years and 70 years
Trial Updated:
11/28/2023
Locations: University of Louisville, Louisville, Kentucky
Conditions: Cardiovascular Diseases, Metabolic Health
Register for Updates
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
NCT04951219
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: L-MARC Research Center, Louisville, Kentucky
Conditions: Non-Alcoholic Fatty Liver Disease
Register for Updates
Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease
NCT03516279
Recruiting
This phase II trial studies how well pembrolizumab and dasatinib, imatinib mesylate, or nilotinib work in treating patients with chronic myeloid leukemia and persistent detection of minimal residual disease, defined as the levels of a gene product called bcr-abl in the blood. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of cancer cells to grow and spread. Dasatinib, imatinib mesylate, and nilotinib may stop the growth of cancer cells by blocking some of the enzyme... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: Jewish Hospital, Louisville, Kentucky +2 locations
Conditions: Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Minimal Residual Disease
Register for Updates