There are currently 1519 clinical trials in Baltimore, Maryland looking for participants to engage in research studies. Trials are conducted at various facilities, including Johns Hopkins University, Johns Hopkins Hospital, University of Maryland and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Effect of Cannabis on Cigarette Use Behavior
NCT06609083
Recruiting
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/23/2025
Locations: Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Cannabis Use, Tobacco Use, Cigarette Smoking
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The CREST-2 Registry
NCT02240862
Recruiting
The objective of C2R is to promote the rapid initiation and completion of enrollment in the CREST-2 randomized clinical trial (clinicaltrials.gov ID NCT02089217). Patients with severe symptomatic and asymptomatic carotid artery occlusive disease will be treated with carotid artery stenting (CAS) performed by experienced and skilled interventionists. Interventionists' eligibility will be determined by a multi-specialty Interventional Management Committee (IMC). Patient eligibility will include pa... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/22/2025
Locations: University of Maryland - Administrative Center, Baltimore, Maryland
Conditions: Carotid Artery Diseases
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Artemis Proximal Femoral Nail for Internal Fixation of Intertrochanteric Femur Fractures
NCT05559736
Recruiting
In February 2021, Altior Trauma Innovations™ announced that it had received 501(k) FDA approval for the Artemis Proximal Femoral Nail (PFN) System for internal fixation of intertrochanteric femur fractures. The objective of this pilot study is to evaluate safety, efficacy and feasibility of the Artemis PFN implant for operative fixation of intertrochanteric femoral fractures, compared to matched historical control patients who received other implants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Conditions: Intertrochanteric Fractures, Femoral Fracture, Femoral Neck Fractures
Register for Updates
Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers
NCT05579743
Recruiting
This research is being done to compare two different methods of wound monitoring for chronic wounds: remote wound monitoring using a smartphone app and in-person wound monitoring in a clinic setting. This will be a pilot non-blinded randomized controlled feasibility trial. The investigators will enroll 120 patients with an active diabetic foot ulcer (DFU) who present to the multidisciplinary diabetic foot clinic in Baltimore, Maryland. Patients will be computer randomized 1:1 to receive wound ca... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Diabetic Foot, Diabetic Foot Ulcer, Wound; Foot, Wound Leg, Wound Heal, Diabetes Complications
Register for Updates
Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
NCT06109181
Recruiting
This is a Phase 1/2, first-in-human, open-label, intravenous, dose-escalating, multicenter trial that is designed to assess the safety and tolerability of LX2020 in adult patients with PKP2-ACM
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/22/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
Register for Updates
Animal-Assisted Visitation Program Chlorhexidine Trial
NCT04171817
Recruiting
Hospital-based Animal-Assisted visitation programs are important complementary therapies, but concerns with infection control may challenge the sustainability of these programs. Pilot data suggest that a low-cost chlorhexidine-based intervention targeted to the dogs involved in the visitation programs holds high potential to prevent pathogen transmission during sessions. In this study, the following aims will be tested: 1) To identify program-related risk factors for acquisition of hospital-asso... Read More
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
01/21/2025
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Methicillin-resistant Staphylococcus Aureus, Clostridium Difficile, Pseudomonas Aeruginosa
Register for Updates
EsophaCap for the Detection of Early Esophageal Carcinoma
NCT04214119
Recruiting
This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma), and gastric cancer via sponge cytology.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: Bayview Medical Center, Baltimore, Maryland +1 locations
Conditions: Barrett Esophagus, Esophageal Cancer, Gastric Cancer
Register for Updates
TMS Related Biomarker Assessments
NCT05660018
Recruiting
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active and sham repetitive transcranial magnetic stimulation (rTMS) in separate sessions. SSD-related biomarkers will be assessed before and after the rTMS administration.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/21/2025
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Schizophrenia Schizoaffective, Schizophrenia
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Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
NCT05734066
Recruiting
This study is conducted in two phases. The phase 1 portion of the study evaluates the safety, tolerability, pharmacokinetics (PK), recommended phase 2 dose (RP2D), and effectiveness of lurbinectedin monotherapy in pediatric participants with previously treated solid tumors. This is followed by the phase 2 portion, to further assess the effectiveness and safety in pediatric and young adult participants with recurrent/refractory Ewing sarcoma.
Gender:
ALL
Ages:
Between 2 years and 30 years
Trial Updated:
01/21/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Refractory Ewing Sarcoma, Relapsed Ewing Sarcoma, Ewing Sarcoma
Register for Updates
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
NCT05830721
Recruiting
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO). ACS is a type of limb ischemia, which means that the limb, such as the arm or leg, loses blood flow. Patients on ECMO can develop this condition for many reasons, but most commonly from the ECMO procedure itself. This most commonly involves the leg. Key symptoms of ACS include severe pain, loss of pulses, loss of feeling, and inability to move the limb. However, be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: The Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
Register for Updates
Direct Observation Study of Kratom Product Effects Among Regular Consumers
NCT06089980
Recruiting
The goal of this observational clinical study is to is to learn more about how commercial kratom products affect healthy adults who consume them regularly. The main questions it aims to answer are: 1. What are the acute physiological, subjective, and cognitive effects of kratom following participant self-administration of a single oral dose of the participants usual kratom product at the participants typical dose? 2. What are the physiological, subjective, and cognitive effects associated with... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/21/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Kratom Pharmacokinetics, Kratom Pharmacodynamics, Kratom
Register for Updates
Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
NCT06299436
Recruiting
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this propo... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/21/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension, Right Heart Failure Due to Left Heart Failure
Register for Updates