There are currently 1543 clinical trials in Baltimore, Maryland looking for participants to engage in research studies. Trials are conducted at various facilities, including Johns Hopkins University, Johns Hopkins Hospital, University of Maryland and Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
REMASTer: REcurrent Brain Metastases After SRS Trial
Recruiting
Randomized, post-market multi-center study investigating the efficacy of two sets of treatment algorithms in brain metastases (BM) patients at the time of first intervention for radiographic progression after stereotactic radiosurgery (SRS), with or without surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Brain Metastases, Radiation Necrosis, Recurrent Tumor, Recurrent Metastases
Diaphragm Structure and Function in Childhood Cancer Survivors
Recruiting
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
12/03/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Childhood Cancer, Cancer Survivors
Diaphragm Structure and Function in Children
Recruiting
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in typically developing children.
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
12/03/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Respiratory Muscle Training
Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity
Recruiting
Spasticity is characterized by increased muscle tension and is a classic consequence of upper motor neuron (UMN) damage in the central nervous system, such as from stroke or trauma. Clinically, it presents as muscle resistance to passive stretching, along with clasp-knife rigidity, clonus, increased tendon reflexes, and muscle spasms. An imbalance of the descending inhibitory and muscle stretch reflexes is thought to be the cause of spasticity. Post-stroke spasticity is a common condition that o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Chronic Pain, Spasticity as Sequela of Stroke, Upper Motor Neuron Lesion
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708
Recruiting
Osteogenesis imperfecta (OI) is a group of congenital and heritable bone disorders that currently affects at least 50,000 people in the United States. OI varies in severity from perinatally lethal to mild forms. The majority of cases is caused by a dominant mutation in type I collagen genes (COL1α1 and COL1α2), altering the quantity or quality of type I collagen. Although OI is typically characterized as a disease of the bone, it is perhaps more accurately described as a connective tissue disor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Kennedy Krieger Institute / Hugo W. Moser Research Institute, Baltimore, Maryland
Conditions: Osteogenesis Imperfecta
Modernizing Perinatal Syphilis Testing
Recruiting
Treponema pallidum is a bacterium that causes the disease syphilis. The primary objective of the study is to evaluate the testing performance of two diagnostic molecular techniques \[quantitative polymerase chain reaction (qPCR) and transcription-mediated amplification (TMA)\] for the detection of Treponema pallidum in maternal and neonatal specimens from participants with the diagnosis of syphilis using the Centers for Disease Control's (CDC's) Sexually Transmitted Infections (STI) Treatment Gu... Read More
Gender:
ALL
Ages:
45 years and below
Trial Updated:
12/02/2024
Locations: Johns Hopkins University, Baltimore, Maryland +1 locations
Conditions: Syphilis
Vincristine Pharmacokinetics in Infants
Recruiting
This pilot trial compares drug exposure levels using a new method for dosing vincristine in infants and young children compared to the standard dosing method based on body surface area (BSA) in older children. Vincristine is an anticancer drug used to a variety of childhood cancers. The doses anticancer drugs in children must be adjusted based on the size of the child because children vary significantly in size (height, weight, and BSA) and ability to metabolize drugs from infancy to adolescence... Read More
Gender:
ALL
Ages:
12 years and below
Trial Updated:
12/02/2024
Locations: Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC
Recruiting
The purpose of this study is to identify the recommended dose of vudalimab to be used in combination with chemotherapy (Part 1) and to evaluate the efficacy and safety of vudalimab plus standard of care chemotherapy relative to pembrolizumab plus chemotherapy (Part 2) as first-line treatment in patients with nonsquamous non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Nonsquamous Non-small Cell Lung Cancer
A Study to Learn About How a New Pneumococcal Vaccine Works in Children
Recruiting
The purpose of this study is to learn about the safety, tolerability and immune effects of a pneumococcal vaccine in toddlers. Participants will take part in this study for approximately 6 or 8 months depending on which group they are assigned to. During this time participants will have 2 clinic visits and 1 phone visit for the 1-Dose group, or 3 clinic visits and 1 phone visit for the 2-Dose group. At these clinic visits, participants will be asked if any side effects were experienced. The pa... Read More
Gender:
ALL
Ages:
Between 12 months and 15 months
Trial Updated:
12/02/2024
Locations: University of Maryland, Baltimore, Center for Vaccine Development and Global Health, Baltimore, Maryland +1 locations
Conditions: Pneumococcal Disease
Black and African Americans Connections to Parkinson's Disease (BLAAC PD)
Recruiting
BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Parkinson Disease
POEM-F for Achalasia International Study
Recruiting
Per-oral endoscopic myotomy (POEM) has emerged as the endoscopic treatment of choice for achalasia, offering comparable symptom relief with laparoscopic Heller's cardiomyotomy. The main concern with POEM is the higher incidence of post-procedure gastroesophageal reflux disease (GERD), occurring in up to 50-60% of patients. In order to reduce the risk of GERD, endoscopic fundoplication has been developed as a novel procedure mimicking surgical anterior partial fundoplication that can be performed... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/29/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Achalasia
Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas
Recruiting
The objective of this study is to assess the tolerability, safety, and efficacy of Liposomal Curcumin (LC) in combination with radiotherapy (RT) and Temozolomide (TMZ) in patients with newly diagnosed High-Grade Gliomas (HGG).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: Johns Hopkins University/Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Glioblastoma