There are currently 1599 clinical trials in Baltimore, Maryland looking for participants to engage in research studies. Trials are conducted at various facilities, including Johns Hopkins University, Johns Hopkins Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and University of Maryland. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
NCT03127267
Recruiting
The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for the treatment of Amyotrophic Lateral Sclerosis (ALS).
Gender:
All
Ages:
Between 18 years and 81 years
Trial Updated:
04/14/2023
Locations: Johns Hopkins Medicine Brain Science Institute, Baltimore, Maryland
Conditions: Amyotrophic Lateral Sclerosis
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Phase III Trial of Sirolimus in IBM
NCT04789070
Recruiting
The hypothesis is that Sirolimus, (Rapamycin (R)) which is currently used in organ transplantation and works by blocking the activity of T effector cells but preserving T regulatory cells, as well as by inducing autophagy (protein degradation), will be effective in IBM to slow or stabilize disease progression, helping to maintain patient function and independence. This phase III trial will confirm pilot data showing statistically significant clinical outcomes.
Gender:
All
Ages:
45 years and above
Trial Updated:
04/11/2023
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Inclusion Body Myositis
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Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation
NCT05008185
Recruiting
This study is being done to demonstrate the effectiveness of Regenerative Peripheral Nerve Interfaces (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation compared to standard of care using a Prospective, Observational Trial
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2023
Locations: The Curtis National Hand Center at Medstar Union Memorial Hospital, Baltimore, Maryland
Conditions: Neuroma
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Remote Monitoring in Progressive Supranuclear Palsy (PSP)
NCT04753320
Recruiting
This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year. Participants will perform supervised remote assessments monthly and in-person assessments approximately every 6 months.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
04/05/2023
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Progressive Supranuclear Palsy
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TMS Related Biomarker Assessments
NCT05660018
Recruiting
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active and sham repetitive transcranial magnetic stimulation (rTMS) in separate sessions. SSD-related biomarkers will be assessed before and after the rTMS administration.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/30/2023
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Schizophrenia Schizoaffective, Schizophrenia
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Blue Light Cystoscopy With Cysview® Registry
NCT02660645
Recruiting
Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Johns Hopkins Medicine, Baltimore, Maryland
Conditions: Bladder Cancer
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Gastrointestinal Microbiome Study of Appendiceal Cancer
NCT02599116
Recruiting
This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Participants will provide fecal samples pre- and post-operatively.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/24/2023
Locations: Mercy Medical Center, Baltimore, Maryland
Conditions: Pseudomyxoma Peritonei, Appendiceal Neoplasm, Cancer, Appendiceal
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LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
NCT02205762
Recruiting
The LCH-IV is an international, multicenter, prospective clinical study for pediatric Langerhans Cell Histiocytosis LCH (age < 18 years).
Gender:
All
Ages:
18 years and below
Trial Updated:
03/21/2023
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Langerhans Cell Histiocytosis
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TMS for Symptom Reduction in Schizophrenia
NCT02916810
Recruiting
To test the hypothesis that functionally navigated repetitive TMS stimulations to the prefrontal cortex (PFC) modulate aberrant cortical electrical activities at PFC circuitry. The TMS location of the PFC site will be individually localized by the symptom-related functional connectivity between PFC and symptom related areas (such as the auditory and language processing cortex). The investigators predict that such modulation will correct abnormal activities in patients with schizophrenia, reduce... Read More
Gender:
All
Ages:
Between 21 years and 62 years
Trial Updated:
03/21/2023
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Schizophrenia and Related Disorders
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SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects
NCT03669614
Recruiting
This is a Phase 1/2a randomized, double-blind, two-part, dose-ascending, multicenter study of AR-501 (gallium citrate) solution, administered via inhalation, in healthy adult and P. aeruginosa infected cystic fibrosis (CF) subjects. Phase 1 of the study in HV subjects will consist of a single-ascending-dose (SAD) cohort, followed by the HV multiple-ascending-dose (MAD) cohort. Phase 2a of the study in CF subjects will consist of a MAD study design. The study will evaluate the safety and pharmaco... Read More
Gender:
All
Ages:
Between 18 years and 49 years
Trial Updated:
03/07/2023
Locations: Research Site, Baltimore, Maryland
Conditions: Cystic Fibrosis
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Imipenem/Cilastatin-XNW4107 Versus Imipenem/Cilastatin/Relebactam for Treatment of Participants With Bacterial Pneumonia (XNW4107-302, REITAB-2)
NCT05204563
Recruiting
This study aims to compare treatment with Imipenem/Cilastatin-XNW4107 (IMI-XNW4107) with imipenem/cilastatin/relebactam (IMI/REL) in participants with hospital-acquired or ventilator-associated bacterial pneumonia (HABP or VAPB, respectively). The primary hypothesis is that IMI-XNW4107 is non-inferior to IMI/REL in all-cause mortality.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/06/2023
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia
Register for Updates
Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling
NCT03412643
Recruiting
This is a prospective, single arm, open label, multicenter interventional study designed to evaluate the efficacy of neoadjuvant chemotherapy with anti-HER2 antibodies in patients with HER2-negative invasive breast cancer who have abnormal HER2 signaling activity determined by the Celcuity CELx HER2 Signaling Function (HSF) testing.
Gender:
Female
Ages:
18 years and above
Trial Updated:
03/03/2023
Locations: Greater Baltimore Medical Center, Baltimore, Maryland
Conditions: HER2-negative Breast Cancer
Register for Updates