Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
Recruiting
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
Gender:
All
Ages:
Between 21 years and 50 years
Trial Updated:
11/27/2023
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Healthy
A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics
Recruiting
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.
Gender:
All
Ages:
Between 25 years and 65 years
Trial Updated:
11/22/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy
A Study of Invasive Hemodynamic for MACHD Registry
Recruiting
This research study is being done to provide comparative data to the Mayo Clinic Adult Congenital Heart Disease Registry.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/20/2023
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Healthy, Congenital Heart Disease
A Study of Pulmonary Hypertension Peripheral Limitations
Recruiting
The investigators are doing this research study to compare whole body aerobic training with isolated leg training (with weights) and its impact on effectiveness in symptoms and quality of life in patients with Pulmonary Arterial Hypertension (PAH).
Gender:
All
Ages:
18 years and above
Trial Updated:
11/16/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Pulmonary Arterial Hypertension, Healthy
Maximizing the Impact of Neuroplasticity Using Transcranial Electrical Stimulation Study 1
Recruiting
Non-invasive neuromodulation, such as transcranial direct current stimulation ( tDCS) , is emerging as an important therapeutic tool with documented effects on brain circuitry, yet little is understood about h ow it changes cognition. In particular, tDCS may have a critical role to play in generalization, that is how training in one domain generalizes to unlearned or unpracticed domains. This problem has resonance for disorders with cognitive deficits, such as schizophrenia. Understanding how t... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
11/15/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Transcranial Direct Current Stimulation, Healthy
A Study of TopSpin360 Training Device
Recruiting
This research is being done to investigate the novel neck strengthening device, TopSpin360 and its effectiveness on measures of neck strength and cognitive function
Gender:
All
Ages:
Between 18 years and 21 years
Trial Updated:
10/19/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy
A Study of LY3819469 in Participants With Impaired and Normal Renal Function
Recruiting
The main purpose of this study is to assess the amount of study drug (LY3819469) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment compared to participants with normal renal function. The safety and tolerability of LY3819469 will also be evaluated in these participants. The study will last up to 17 weeks including screening period.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/18/2023
Locations: Nucleus Networks, Saint Paul, Minnesota
Conditions: Renal Insufficiency, Healthy
A Study of Adipose Tissue in Adaptive Responses to Exercise
Recruiting
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/04/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Healthy, Obesity
Atenolol for the Prevention of Osteoporosis (APO)
Recruiting
Evaluate whether treatment with a widely used beta blocker, atenolol, will prevent bone loss at the lower back and hip in postmenopausal women.
Gender:
Female
Ages:
Between 50 years and 75 years
Trial Updated:
10/04/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Healthy
Beetroot Juice and Sleep
Recruiting
The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/02/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Healthy
Integrated Cancer Repository for Cancer Research
Recruiting
The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer... Read More
Gender:
All
Ages:
Between 19 years and 110 years
Trial Updated:
09/29/2023
Locations: Riverwood Healthcare Center, Aitkin, Minnesota +5 locations
Conditions: Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer, Thymus Cancer, Colon Cancer, Rectal Cancer, GIST, Anal Cancer, Bile Duct Cancer, Duodenal Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer, Small Intestine Cancer, Peritoneal Surface Malignancies, Familial Adenomatous Polyposis, Lynch Syndrome, Bladder Cancer, Kidney Cancer, Penile Cancer, Prostate Cancer, Testicular Cancer, Ureter Cancer, Urethral Cancer, Hypopharyngeal Cancer, Laryngeal Cancer, Lip Cancer, Oral Cavity Cancer, Nasopharyngeal Cancer, Oropharyngeal Cancer, Paranasal Sinus Cancer, Nasal Cavity Cancer, Salivary Gland Cancer, Skin Cancer, CNS Tumor, CNS Cancer, Mesothelioma, Breast Cancer, Leukemia, Melanoma, Sarcoma, Unknown Primary Tumor, Multiple Myeloma, Ovarian Cancer, Endometrial Cancer, Vaginal Cancer, Neuroendocrine Tumors, Plasma Cell Dyscrasia, Healthy Control
Longitudinal Study to Determine the Effectiveness of the Mobility Checkup for Older Adults
Recruiting
The investigators are developing a new, preventative physical therapy model of care for older adults called Mobility Checkup (MC). Proposed as an annual visit, the MC includes measurement of physical performance and education regarding the importance of maintaining mobility for overall health. The purpose of this study is to determine the feasibility of and begin data collection for, a longitudinal study of the effectiveness of the Mobility Checkup with a small cohort. This activity will evaluat... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
09/25/2023
Locations: College of St. Scholastica-Health Science Center, Duluth, Minnesota
Conditions: Healthy Aging