There are currently 901 clinical trials in Minneapolis, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Minnesota, Hennepin County Medical Center, Abbott Northwestern Hospital and University of Minnesota/Masonic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's Hospital of Minnesota, Minneapolis, Minnesota +1 locations
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
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GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS
NCT05266001
Recruiting
The GRACE-2 study is a prospective, multi-center, double-blind, randomized controlled trial of the drug GM-CSF vs placebo in children with sepsis-induced multiple organ dysfunction syndrome (MODS) who have immunoparalysis with mild to moderate inflammation.
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Children's Hospital of Minnesota, Minneapolis, Minnesota +1 locations
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome
Register for Updates
The ACT Trial: Effects of Combined Aerobic Exercise and Cognitive Training in MCI
NCT03313895
Recruiting
This multi-site clinical trial occurs at the University of Minnesota and University of Rochester. It tests the efficacy and additive/synergistic effects of an ACT intervention on cognition and relevant mechanisms (aerobic fitness, Alzheimer's disease [AD] signature cortical thickness, and default mode network [DMN]) in older adults with amnestic MCI (aMCI).
Gender:
All
Ages:
65 years and above
Trial Updated:
01/05/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Mild Cognitive Impairment
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Radioembolization of Primary and Secondary Liver Malignancies and The Effect On The Immune System
NCT03889093
Recruiting
The goal of this study is to understand the immunologic effects radioembolization has on the immune system. This will be done by evaluating the changes on biopsy, peripheral blood monocytes, and cytokines.
Gender:
All
Ages:
22 years and above
Trial Updated:
10/28/2022
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hepatocellular Carcinoma, Secondary Malignant Neoplasm of Liver
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NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Chemical and/or Thermal Injuries
NCT04081103
Recruiting
This study will enroll participants with a non-infected, corneal persistent epithelial defect (PED) resulting from an ocular chemical and/or thermal ocular injury which is non-responsive or refractory to current standard of care for at least 14 days. It will assess the efficacy and safety of Nexagon® (lufepirsen) plus standard of care versus NEXAGON-vehicle (placebo) plus standard of care. The recovery of the corneal epithelium will be the primary outcome measure, defined as a cornea that re-epi... Read More
Gender:
All
Ages:
All
Trial Updated:
08/25/2022
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Corneal Persistent Epithelial Defect
Register for Updates
Sodium Glucose Co-Transporter 2 (SGLT2) and STEMI
NCT05305911
Recruiting
The purpose of the research is to determine whether a medication called dapagliflozin will improve the heart's function and reduce its enlargement after a heart attack. Participation in this study will involve taking the medication dapagliflozin (or a placebo) once daily for six months, one cardiac magnetic resonance imaging (MRI) test during your initial hospitalization, follow-up phone calls at 1 and 3 months, and one cardiac MRI and clinic visit at six months.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/04/2022
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Heart Attack, Enlarged Heart
Register for Updates
Native Coronary Artery Instead of SAphenous Vein Graft Intervention for Treatment of Significant Saphenous Vein Graft Lesions
NCT05187351
Recruiting
The primary study objective of the NASA registry is to evaluate the 12-month incidence of target vessel failure (TVF) in patients who present with saphenous vein graft (SVG) lesions and undergo percutaneous coronary intervention (PCI) of the corresponding native coronary artery.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2022
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Target Vessel Failure in Saphenous Vein Grafts, Percutaneous Coronary Intervention
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Radial vs. State-Of-The-Art Femoral Access for Bleeding and Access Site Complication Reduction in Cardiac Catheterization (REBIRTH)
NCT04077762
Recruiting
This is a phase IV, prospective, open label, randomized-controlled study that will compare radial access with state-of-the-art femoral access in patients without ST-segment elevation acute myocardial infarction undergoing cardiac catheterization. Subjects will be randomized 1:1 into 2 treatment groups: radial access and state-of-the-art femoral access. Randomization will be performed in blocks of 50 per site. Similarly, a second sub-randomization will be performed in the femoral access group int... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/27/2022
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Patient Satisfaction, Vascular Access Complication
Register for Updates
Artisan Aphakia Lens for the Correction of Aphakia in Children
NCT01547442
Recruiting
The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
06/24/2022
Locations: University of Minnesota, MN Lions Children's Eye Clinic, Minneapolis, Minnesota
Conditions: Aphakia
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Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients
NCT04083690
Recruiting
Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical dyssynchrony. A traditional CRT device has pacing leads implanted within the right atrium (RA), the right ventricle (RV), and within a coronary vein overlying the lateral or posterior left ventricle (LV). Within the past decade, various multi-center randomized controlled... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
06/08/2022
Locations: Minneapolis Heart Institute (Abbott Northwestern Hospital), Minneapolis, Minnesota
Conditions: Heart Failure, Systolic
Register for Updates
Racial and Economic Disparities and Unmet Needs in Patients With Severe Aortic Valvular Disease
NCT04525937
Recruiting
Common barriers to receiving appropriate guideline-driven care for patients with severe aortic stenosis include referral biases by primary care providers (lack of provider education), patient comorbidities (degree of fragility), as well as psychosocial issues and cultural barriers. Additionally, race, ethnicity, socioeconomic status (SES) and education level are shown to be persistent barriers to accessing healthcare services and healthcare systems, creating a significant practice gap between va... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/07/2022
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Disparities in Treatment of Aortic Valve Stenosis, Aortic Valve Stenosis
Register for Updates
Real-Time Muscle Pressure Measurements in Patients at Risk for Acute Compartment Syndrome
NCT04671173
Recruiting
The purpose of this trial is to conduct a pilot study that will aid in the design of an evaluation of the clinical benefit of MY01, an FDA cleared device, that allows continuous monitoring of intracompartmental muscle pressure in patients at risk for developing acute compartment syndrome. MY01 has previously been successfully tested on animal and Human cadaver Acute Compartment Syndrome models within the RI MUHC through Department of Defense research Grant (Combat Casualty Care Research Program... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/04/2022
Locations: Hennepin County Medical Center - Orthopaedic Research, Minneapolis, Minnesota
Conditions: Acute Compartment Syndrome
Register for Updates