There are currently 916 clinical trials in Minneapolis, Minnesota looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Minnesota, Hennepin County Medical Center, Abbott Northwestern Hospital and University of Minnesota/Masonic Cancer Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic Malignancies
NCT05705505
Recruiting
This study will assess the safety and efficacy of increasing doses of narazaciclib (ON 123300) in combination with the standard daily dose (2.5mg) of letrozole in patients with Recurrent Metastatic Low-grade Endometrioid Endometrial Cancer and other Gynecologic Malignancies.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota
Conditions: Endometrioid Endometrial Cancer
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SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study
NCT04054401
Recruiting
The purpose of the study is to evaluate the safety and tolerability of DRG stimulation when placing a neurostimulator during the same procedure as implantation of spinal fixation with or without interbody cage systems in patients with chronic back and/or leg pain requiring single level spinal fusion.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
11/21/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Spinal Fusion, Radiculopathy Lumbar, Chronic Pain
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NeuroGlove Anxiety and Depression Study
NCT06065787
Recruiting
This is a prospective, homebased, interventional clinical study containing 10 subjects who will be enrolled. Approximately 10 (10) subjects with active anxiety and depression symptoms will receive treatment using the NeuroGlove.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/03/2023
Locations: NeuroGlove, Minneapolis, Minnesota
Conditions: Anxiety, Depression, Anxiety Depression, Depression, Anxiety
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Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Epidermolysis Bullosa (Phase III)
NCT05838092
Recruiting
The aim of this clinical trial is to investigate the safety and efficacy of allo-APZ2-OTS administered intravenously to subjects with recessive dystrophic epidermolysis bullosa (RDEB) compared to placebo.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
10/27/2023
Locations: Masonic Cancer Center and Medical Center Minneapolis, Minneapolis, Minnesota
Conditions: Epidermolysis Bullosa
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
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Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Minneapolis Heart Institute / Abbott Northwestern Hospital, Minneapolis, Minnesota
Conditions: Abdominal Aortic Aneurysm
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OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps
NCT03747458
Recruiting
This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 120 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo). For the PK sub-study, up to 14 subjec... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
09/22/2023
Locations: Children's Minnesota, Minneapolis, Minnesota
Conditions: Bilateral Nasal Polyposis
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PV Loop and Pulmonary Hypertension
NCT05484596
Recruiting
The right ventricular (RV) systolic function is a key determinant of outcome in patients with pulmonary hypertension and elevated pulmonary vascular resistance. As the pulmonary artery pressure and vascular resistance increase (i.e. RV afterload) in these patients, so does the right ventricular contractility in an attempt to maintain cardiac output. This is response of a ventricle to its afterload is termed ventriculo-arterial (VA) coupling. However, there is a limit to this increase in contract... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
09/22/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pulmonary Vascular Resistance Abnormality
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Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury
NCT04933448
Recruiting
The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI). The secondary objective is a preliminary evaluation of the outcomes of children who have had the standard of care plus the KD, compared to those with standard of care alone. Outcome measures for the secondary objective will include: need for ventriculoperitoneal shunt, duration of unconsciousness, need for any ty... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
09/15/2023
Locations: Gillette Children's Specialty Healthcare, Minneapolis, Minnesota +1 locations
Conditions: Traumatic Brain Injury
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Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries With Multiple Myeloma
NCT03127761
Recruiting
Multiple myeloma (MM) is the second most common hematologic malignancy in adults. The current standard of care for MM patients fit to undergo high dose conditioning chemotherapy is an autologous HCT (autoHCT). Allogeneic HCT (alloHCT) is the only potentially curative therapy available to patients with MM. However, the significant morbidity and mortality of this procedure historically limited its application in older patients. Thus, although potentially curative, standard risk MM patients have e... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/29/2023
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Multiple Myeloma
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Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis
NCT02934477
Recruiting
This observational study will compare outcomes of a prospectively-enrolled cohort of Hematopoietic Stem Cell Transplant (HCT) recipients with outcomes of a cohort of age-matched historical non-HCT controls. Patients undergoing alloHCT will receive HCT in a US transplant center and be reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) using well-established CIBMTR report forms and data collection procedures as well as a study-specific supplemental form. Data on... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
08/29/2023
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Myelofibrosis
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Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
NCT01060371
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
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