There are currently 206 clinical trials in Columbia, Missouri looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Missouri, Ellis Fischel Cancer Center - Columbia, Ellis Fischel Cancer Center at University of Missouri - Columbia and University of Missouri - Ellis Fischel. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Skin Preparation for Elective Foot and Ankle Surgery
NCT05401292
Recruiting
Surgical site infections (SSIs) make about 31% of all nosocomial infections and they are the most common hospital-acquired infection. For foot and ankle elective interventions, SSI rate is reported between 0.4% and 3.6%. This study will investigate the effectiveness of skin cleaning with isopropyl alcohol and scrubbing with chlorhexidine soap before standard skin preparation in reducing microbial load and surgical site infections for elective foot and ankle surgeries. Current standard of care in... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: University of Missouri, Columbia, Missouri
Conditions: Microbial Colonization, Foot and Ankle Disorders
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Total Shoulder Arthroplasty Multi-Center Registry
NCT03511586
Recruiting
The objective of the study is a multi-center prospective registry to collect clinical outcomes of anatomic and reverse total shoulder arthroplasty.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
07/27/2023
Locations: Not set, Columbia, Missouri
Conditions: Shoulder Arthroplasty
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Immediate Vs. Delayed Weight Bearing Postoperative Protocol in Diabetic Ankle Fractures
NCT03966027
Recruiting
Operatively managed diabetic ankle fractures have significant risk for complications. The cause for failure is likely multifactorial, however, a component of failure has to do with an inability to process pain and pressure normally. This loss of protective sensation allows for an increase in abnormal stresses placed on the recently repaired fractures. Historically, diabetics have been kept non weight bearing for extended periods of time, which has its own functional and cardiovascular issues. Th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: University of Missouri Health System, Columbia, Missouri
Conditions: Ankle Fractures
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Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
NCT01526681
Recruiting
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting. Optional addendums 1 and 2 included in the protocol are intended to establish comparative groups and focused subgroups within the registry.
Gender:
All
Ages:
All
Trial Updated:
07/17/2023
Locations: RANGER & MATCH: University of Missouri - Columbia, Columbia, Missouri
Conditions: Peripheral Nerve Injuries
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DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
NCT03115333
Recruiting
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2023
Locations: University of Missouri - Ellis Fischel, Columbia, Missouri
Conditions: Gliosarcoma, Recurrent Glioblastoma
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Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
NCT02201992
Recruiting
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-sma... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/20/2023
Locations: University of Missouri - Ellis Fischel, Columbia, Missouri
Conditions: ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
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Curvafix® Intramedullary System for Fixation of Pelvic and Acetabular Fractures, A Post Market Evaluation
NCT05606042
Recruiting
Prospective, single arm, post-market evaluation to evaluate the use and performance of the IM Implant in a post market setting.
Gender:
All
Ages:
All
Trial Updated:
06/09/2023
Locations: Missouri Orthopaedic Institute, Columbia, Missouri
Conditions: Pelvic Ring Fracture, Acetabular Fracture, Pelvic Fracture, Pelvic Fracture Acetabulum
Register for Updates
The Drinking Dashboard Study
NCT05630625
Recruiting
This study aims to develop and pilot test the efficacy of a "Drinking Dashboard" providing participants weekly feedback on the risk factors and consequences of blackout.
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
06/07/2023
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Alcohol Drinking
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Smoking Cessation Behavioral Treatment Study
NCT03948893
Recruiting
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/31/2023
Locations: University of Missouri - Columbia, Columbia, Missouri
Conditions: Tobacco Use Disorder
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NICU Oxygen Control Study
NCT04269161
Recruiting
Prematurely born infants in the hospital neonatal intensive care unit (NICU) will be included in the study. This clinical trial is a randomized crossover study to show that our automated oxygen control device performance is no worse than a NICU nurse in keeping a premature neonate's SPO2 within the prescribed range. Since subjects receive the device (automatic oxygen control) and the standard of care (manual control by a nurse), every subject serves as their own perfectly matched control. Perfor... Read More
Gender:
All
Ages:
All
Trial Updated:
05/19/2023
Locations: University of Missouri, Columbia, Missouri
Conditions: Hyperoxia, Hypoxia
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Membrane Target Detection for Leukemia Treatment
NCT04841447
Recruiting
Acute myeloid leukemia (AML) accounts for more than 40% of leukemia mortality in the United States. Each year around ten thousand people die from the disease, most within a few years of diagnosis. Despite advances in our understanding of the disease, few improvements in the therapy of AML have been made. Collecting specimens from the blood and bone marrow will increase understanding of the effect of Dipeptidyl Peptidase-4 (DPP-4) Inhibitors on human AML-SCP to develop individualized therapies. W... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/25/2023
Locations: University of Missouri, Columbia, Missouri
Conditions: Hematological Malignancy
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Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: University of Missouri Health System, Columbia, Missouri
Conditions: Spinal Muscular Atrophy (SMA)
Register for Updates