Missouri is currently home to 1891 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies
NCT04919018
Recruiting
Though common, morbidities related to upper airway disease in primary ciliary dyskinesia (PCD) and primary immunodeficiencies (PID) have not been fully characterized. These conditions can be difficult to distinguish due to their overlapping phenotypes. The sinonasal and middle ear features are often identified as most problematic by patients and their families, and optimal, highly effective treatment regimens have not been established. The main objective of this project is to characterize and co... Read More
Gender:
ALL
Ages:
Between 5 years and 45 years
Trial Updated:
10/07/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Primary Ciliary Dyskinesia, Kartagener Syndrome, Primary Immune Deficiency
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Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults
NCT04702243
Recruiting
The investigators will utilize a systematic approach for the diagnostic evaluation of patients to identify characteristics which may distinguish between Primary Immunodeficiency (PID) disorders versus Primary Ciliary Dyskinesia (PCD).
Gender:
ALL
Ages:
Between 5 years and 45 years
Trial Updated:
10/07/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Primary Ciliary Dyskinesia, Primary Immune Deficiency, Kartagener Syndrome
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Targeted Lifestyle Change Group Prenatal Care
NCT04090307
Recruiting
To conduct a randomized trial to determine the effect of Targeted Lifestyle Change Group Prenatal Care (TLC) on maternal and neonatal outcomes in women at high risk for developing gestational diabetes mellitus (GDM).
Gender:
FEMALE
Ages:
13 years and above
Trial Updated:
10/07/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Pregnancy, Gestational Diabetes
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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
NCT03295981
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Saint Louis University, Saint Louis, Missouri
Conditions: Giant Cell Tumor of Bone
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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
NCT05926765
Recruiting
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: University of Missouri, Columbia, Missouri
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
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PAL to Improve Oral Feeding for Infants With Chronic Lung Disease
NCT05446389
Recruiting
The purpose of this study is to investigate the effects of the Pacifier Activated Lullaby (PAL) intervention on the transition to oral feeding for preterm infants with chronic lung disease and respiratory distress syndrome that require non-invasive respiratory support at 34 weeks PMA. This study will utilize a clinical trial design. Participants will be randomized into two groups. One group will receive the PAL intervention, the other group serving as a no contact control. Participants will be m... Read More
Gender:
ALL
Ages:
Between 1 day and 33 weeks
Trial Updated:
10/03/2024
Locations: University of Missouri Healthcare, Columbia, Missouri
Conditions: Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia, Preterm Birth
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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: David C. Pratt Cancer Center, Saint Louis, Missouri
Conditions: HER2-positive Advanced Solid Tumor
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Phase 1b Combo w/ Ribociclib, Alpelisib, or Everolimus
NCT05508906
Recruiting
This is a Phase 1b open-label, 2-part study in 3 treatment groups. The 3 treatment groups are as follows: Treatment Group 1: OP-1250 in combination with ribociclib (KISQALI®, Novartis Pharmaceuticals Corporation). Treatment Group 2: OP-1250 in combination with alpelisib (PIQRAY®, Novartis Pharmaceuticals Corporation). Treatment Group 3: OP-1250 in combination with everolimus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: Washington University, School of Medicine, Saint Louis, Missouri
Conditions: Metastatic Breast Cancer, Advanced Breast Cancer, HER2-negative Breast Cancer, ER-positive Breast Cancer, Breast Cancer
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HER2-positive Breast Cancer Registry
NCT06603597
Recruiting
The goal of this observational study is to better understand links between patient or tumor characteristics and outcomes in HER2-positive breast cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: KUCC - North, Kansas City, Missouri
Conditions: HER2 + Breast Cancer
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NeuroControl of Nicotine Dependence
NCT06347055
Recruiting
The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
09/30/2024
Locations: Health Neuroscience Center, Columbia, Missouri
Conditions: Nicotine Dependence
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Neoadjuvant SGLT2 Inhibition in High-Risk Localized Prostate Cancer
NCT04887935
Recruiting
This is a study of the tolerability and safety of neoadjuvant dapagliflozin for patients with high-risk or very high risk prostatic adenocarcinoma prior to radical prostatectomy. The primary hypothesis is that four weeks of daily dapagliflozin prior to surgery is well-tolerated and safe to use in this patient population.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Prostate Cancer, Cancer of Prostate
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Early Neurovascular Adaptations in Aging Women
NCT06520982
Recruiting
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
09/27/2024
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Women, Sympathetic Nervous System, Aging, Blood Flow
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