Missouri is currently home to 1899 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Naltrexone Neuroimaging in Teens with Eating Disorders
NCT05509257
Recruiting
Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders. The hypothesis is that fMRI will be able to detect acute reward pathway modulation by naltrexone (an opioid antagonist) in pre-defined regions of interest (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex).
Gender:
ALL
Ages:
Between 13 years and 21 years
Trial Updated:
11/01/2024
Locations: Children's Mercy Research Institute, Kansas City, Missouri
Conditions: Eating Disorders, Binge Eating, Purging (Eating Disorders), Bulimia Nervosa, Anorexia Nervosa, Atypical
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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768
Recruiting
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be bette... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri
Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma
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NSAIDs Stent Study
NCT03638999
Recruiting
This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment, randomization, assessment procedures and implementation of the study intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Ureteral Stent Placement, Kidney Stone
Register for Updates
Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study
NCT06289413
Recruiting
Observational two phase, retrospective and prospective registry study to assess the prevalence of and characterize outcomes of autonomic dysfunction (AD) in patients who undergo bariatric surgery (BS) and to better define the underlying pathophysiology of AD following BS.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/25/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: Autonomic Dysfunction, Orthostatic Intolerance
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Vascular Closure With a Device Compared to Manual Compression After Atrial Fibrillation Ablation: The LockeT II Study
NCT06078735
Recruiting
The LockeT II study is a single center, prospective randomized study. It is intended to study the effectiveness of using LockeT device to gain hemostasis after venous procedures as compared to Manual Compression (MC). Approximately 110 patients will be enrolled.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: Atrial Fibrillation, Hemostasis
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Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma
NCT05281731
Recruiting
This clinical study to evaluate sonobiopsy is significant because sonobiopsy will fundamentally enhance the clinician's insight into the molecular features of an intracranial lesion to tailor treatment approaches and optimize outcomes. In addition to the standard diagnostics of anatomic imaging and surgical histology, sonobiopsy has the potential to become the third pillar for brain tumor management by radically advancing the ability to easily and regularly acquire tumor genetic and molecular si... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/25/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Glioblastoma, Glioblastoma Multiforme
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PUSH-IT Continuing Enteral Feeds for Tracheostomy
NCT05906472
Recruiting
The goal of this clinical trial is to evaluate nutrition administration in the time around the tracheostomy in patients with breathing tubes. The main questions it aims to answer are: * Will continuing nutrition up to the time of surgery (tracheostomy) decrease nutrition interruptions, thereby increasing food intake? * Does continuing nutrition up to the time of surgery increase instances of food going into the lungs or lung infections? Researchers will compare patients who have nutrition with... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: HCA Research Medical Center, Kansas City, Missouri
Conditions: Tracheostomy Complication, Critical Illness, Nutritional Deficiency
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Dynamic Data-Driven Management of Atrial Fibrillation Using Implantable Cardiac Monitors: The MONITOR-AF Study
NCT06352060
Recruiting
Observational, multi-center, retrospective study to evaluate the use of ICM (implantable cardiac monitor) versus traditional, non-ICM (non-implantable cardiac monitor) methods such as ECGs (electrocardiogram), Holter, and mobile cardiac outpatient telemetry (MCOT) units.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: Atrial Fibrillation
Register for Updates
Infant Survival and Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia, a Phase III Trial
NCT06179472
Recruiting
The purpose of the study is to determine the infant survival and long-term effects of performing Fetoscopic Endoluminal Tracheal Occlusion (FETO) surgery and removal of the BALT Goldbal2 balloon at Children's Mercy Hospital. We hypothesize that FETO balloon placement may increase survival and decrease morbidity when compared to standard prenatal care for the treatment of severe left or right congenital diaphragmatic hernia (CDH).
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
10/22/2024
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Congenital Diaphragmatic Hernia
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Impact of Negative Pressure Ventilation in Patients Hospitalized with Acute Hypercapnic Respiratory Failure
NCT06108284
Recruiting
The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
10/21/2024
Locations: University of Missouri Hospitals, Columbia, Missouri
Conditions: Acute Hypercapnic Respiratory Failure
Register for Updates
Building a Renewed ImaGe After Head & Neck Cancer Treatment (BRIGHT) Multi-Site RCT
NCT05442957
Recruiting
In this multi-center randomized clinical trial, head and neck cancer (HNC) survivors with clinically significant body image distress (BID) (N=180) will be randomized to BRIGHT (a brief video tele-cognitive behavioral therapy intervention) or Attention Control (AC, a manualized tele-supportive care intervention that controls for professional attention, dose, delivery method, and common factors). HNC survivors will complete IMAGE-HN (a validated patient-reported outcome measure \[PROM\] of HNC-rel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Head and Neck Cancer, Body Image Disturbance, Body Image, Survivorship, Psychosocial Impairment, Mental Health Issue
Register for Updates
First in Human Study of TORL-3-600 in Participants With Advanced Cancer
NCT05948826
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-3-600 in patients with advanced cancer
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/18/2024
Locations: Washington University School of Medicine-Siteman Cancer Center, Saint Louis, Missouri
Conditions: Advanced Solid Tumor, Colorectal Cancer
Register for Updates