Missouri is currently home to 1929 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Decreasing Emergence Delirium With Personalized Music
Recruiting
This is a prospective randomized controlled trial in children 3-9 years of age undergoing myringotomies at Washington University in St. Louis to assess the impact of perioperative personalized music on the incidence of emergence agitation.
Gender:
All
Ages:
Between 3 years and 9 years
Trial Updated:
02/07/2024
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Emergence Delirium
Personalized Prediction of Persistent Postsurgical Pain
Recruiting
P5 is planned as a prospective observational study, collecting evidence-based perioperative data on patient history and demographics, physical function, cognitive measures, psychological, and biological markers associated with increased pain susceptibility, and psychophysical measures of pain processing. The study will use daily ecologic momentary assessment (EMA) of physical and emotional parameters, and collect data on perioperative events. Follow up will occur 3 months and 6 months postoper... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2024
Locations: Washington University in St Louis, Saint Louis, Missouri
Conditions: Pain, Postoperative
An Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma and in Subjects With High-Risk Multiple Myeloma
Recruiting
This study is a multi-cohort, open-label, multicenter Phase 2 study to evaluate the efficacy and safety of bb2121 in participants with relapsed and refractory multiple myeloma (RRMM) (Cohort 1), in participants with RRMM who receive bridging therapy with talquetamab (Cohort 1b), in participants with multiple myeloma (MM) having progressed within 18 months of initial treatment with autologous stem cell transplantation (ASCT) (Cohort 2a) and without ASCT (Cohort 2b) or, in participants with inadeq... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/07/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Multiple Myeloma
Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation
Recruiting
800 adult first time kidney transplant recipients will be enrolled in the Observational Study and followed to evaluate their Human Leukocyte Antigen (HLA)-DR/DQ molecular mismatch (mMM) score as a risk-stratifying prognostic biomarker. Six months after transplant the study will identify those who meet the eligibility criteria for the Nested Randomized Control Trial (RCT). 300 eligible subjects will be randomized 2:1 to abatacept or Standard of care (SOC) in the randomization and followed for 18... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
02/06/2024
Locations: Washington University School of Medicine in St. Louis, Saint Louis, Missouri
Conditions: Kidney Transplant
Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study
Recruiting
This phase III trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may in... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Saint Francis Medical Center, Cape Girardeau, Missouri
Conditions: Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
Recruiting
The purpose of this registry is to address optimal platelet inhibition during the early management of MI patients prior to coronary angiography or CABG.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Myocardial Infarction
Low Field Magnetic Resonance Imaging Assessment With Outpatients
Recruiting
The objective of the study is to perform imaging assessments of an early stage magnetic resonance imaging (MRI) system on patients using low field magnetic strength.
Gender:
All
Ages:
Between 0 years and 22 years
Trial Updated:
02/05/2024
Locations: Children's Mercy Kansas City, Kansas City, Missouri
Conditions: Conditions Requiring a Brain Magnetic Resonance Imaging, Head Computerized Tomography, or Head Ultrasound
Low Field and High Field Magnetic Resonance Imaging Assessments on Pediatric Patients
Recruiting
Hyperfine Research, Inc. has taken advantage of technological advances and developed an MRI device that is not only portable, but also uses a very-low magnetic field strength, [less than 0.2 Tesla or approximately 10 times less] than the field strength of conventional devices. This critical difference allows HRI to address MRI's core challenges by, first, operating at very low magnetic field strengths, eliminating the need for special rooms or shielding. Second, there are minimal safety concerns... Read More
Gender:
All
Ages:
Between 0 days and 22 years
Trial Updated:
02/05/2024
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Conditions Requiring a Brain Magnetic Resonance Imaging, Head Computerized Tomography, or Head Ultrasound
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Recruiting
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Sundance Clinical Research, Saint Louis, Missouri
Conditions: Knee Osteoarthritis
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
Role of Novel ILR in the Management of PVCs
Recruiting
This prospective, observational study is a single center clinical registry of patients referred for management of symptomatic or asymptomatic Premature Ventricular Contractions (PVCs). Subjects will be followed through 12 months. The study will enroll approximately 50 patients.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: PVC - Premature Ventricular Contraction, Myocarditis
Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)
Recruiting
This is a multi-center, double-masked, randomized, placebo-controlled, parallel-group, efficacy, safety, and tolerability study evaluating the efficacy of Dupilumab in the treatment of signs and symptoms of atopic keratoconjunctivitis (AKC).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Silverstein Eye Centers, Kansas City, Missouri
Conditions: Atopic Keratoconjunctivitis