Missouri is currently home to 1929 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RCT Evaluating Standardized Counseling on Early Discontinuation for Irregular Bleeding in Nexplanon Users
Recruiting
Clinician counseling for implant users should involve an explanation of the likelihood of irregular bleeding and the possibility of continued or frequent bleeding throughout three years of use. If that counseling does not provide specifics of the actual distribution of bleeding patterns described in published literature, there remains the real possibility of biased or directed counseling, leading to an inaccurate and exaggerated expectation of potential bleeding changes. This study aims to evalu... Read More
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
01/28/2024
Locations: Planned Parenthood of the St. Louis Region and Southwest Missouri, Saint Louis, Missouri
Conditions: Birth Control, Contraception, Contraceptive Usage, Family Planning
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
All
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Galen Research, Chesterfield, Missouri
Conditions: NASH - Nonalcoholic Steatohepatitis
An Efficient Treatment for Posttraumatic Injury for Firefighters
Recruiting
The goal of this two-arm pilot randomized controlled trial is to test a behavioral intervention that integrates three evidence-based cognitive behavioral interventions (written exposure therapy; WET, cognitive behavioral therapy for insomnia; CBT-I, and cognitive behavioral therapy for nightmares; CBT-N) among firefighters. The main questions it aims to answer are: Is the behavioral intervention feasible, acceptable, and effective in reducing symptoms of posttraumatic stress, insomnia, and nigh... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/23/2024
Locations: NDRI_USA, Kansas City, Missouri
Conditions: Posttraumatic Stress Disorder, Insomnia, Nightmare
A Long-term Follow-up Study of Patients Who Received VOR33
Recruiting
VOR33 long-term follow-up (LTFU) study
Gender:
All
Ages:
All
Trial Updated:
01/23/2024
Locations: Washington University School of Medicine Siteman Cancer Center, Saint Louis, Missouri
Conditions: Leukemia, Myeloid, Acute
Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion
Recruiting
Prospective, randomized control trial To determine if oral caffeine decreases the frequency of opioid demand in children with adolescent idiopathic scoliosis after their spinal fusion surgery To compare pain scale ratings, number of requests for diazepam, average heart rate, average blood pressure, sex, age, ethnicity, post-op day of discharge, operative time, estimated intraoperative blood loss, remittance post-surgery, length of hospital stay, and segments fused during spinal fusion surgery.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
01/22/2024
Locations: Children'S Mercy Hospitals & Clinic, Kansas City, Missouri
Conditions: Adolescent Idiopathic Scoliosis
Effect of Knee Pain on Walking Biomechanics
Recruiting
The goal of this study is to determine if pain in one knee influences loading of the other knee during different types of walking. The main questions it aims to answer are: How does unilateral knee pain affect contralateral knee joint loading during different types of walking? Does movement and loading change at the hips, knees, and ankles during prolonged walking in persons with painful knee osteoarthritis? Participants will: Fill out questionnaires/surveys Complete clinical examinations Wal... Read More
Gender:
All
Ages:
45 years and above
Trial Updated:
01/17/2024
Locations: Saint Louis University, Saint Louis, Missouri
Conditions: Osteoarthritis, Knee
Investigation of Inflammation in Alzheimer's Disease and Related Dementias (ADRD) Using [11C]-CS1P1
Recruiting
This study involves a brain positron emission tomography (PET) scan with a new, investigational radioactive tracer called [11C]-CS1P1 to identify inflammation in the brain by testing with healthy older adults and with cognitively impaired older adults.
Gender:
All
Ages:
50 years and above
Trial Updated:
01/12/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Alzheimer Disease
Imaging Biomarkers in Preclinical and Symptomatic AD
Recruiting
The purpose of this research study is to evaluate adult children of parents with and without Alzheimer's disease which represent an ideal population for investigating the biological changes that precede the clinical onset of AD. The investigators will be imaging the brain to detect the presence of amyloid deposits (plaques in the brain). Amyloid is a protein that may be related to dementia of Alzheimer's disease (DAT).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/12/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Alzheimer Disease
C-Brace Prospective Registry
Recruiting
To gather prospective safety and effectiveness data for the C-Brace System following the standard of care.
Gender:
All
Ages:
All
Trial Updated:
01/09/2024
Locations: P&O Care x Ottobock.care, Saint Louis, Missouri
Conditions: Pareses, Lower Extremity
NKTR-255 vs Placebo Following CD19-directed CAR-T Therapy in Patients With Relapsed/Refractory Large B-cell Lymphoma
Recruiting
This study will evaluate the safety and efficacy of NKTR-255 following CD19-directed chimeric antigen (CAR)-T cell therapy in patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL). NKTR-255 is an investigational IL-15 receptor agonist designed to boost the immune system's natural ability to fight cancer. T cells are infection fighting blood cells that can kill tumor cells. Chimeric antigen (CAR)-T cell product consists of genetically engineered T-cells, modified to recognize C... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Saint Louis University, Saint Louis, Missouri
Conditions: Non-Hodgkin Lymphoma, Relapsed/Refractory Diffuse Large B-cell Lymphoma
Telehealth as a Modality to Increase the Uptake of PrEP Services in Black and Latino: "e-PrEP"
Recruiting
To evaluate if utilizing Telehealth medicine for access to HIV PrEP will engage more Black and Latino Men who have sex with Men (MSM)
Gender:
Male
Ages:
18 years and above
Trial Updated:
01/03/2024
Locations: Vivent Health, Saint Louis, Missouri
Conditions: HIV Prevention
Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology
Recruiting
At present, it is not clear whether performing a hip arthroscopy at the same time as a PAO improves patient outcomes after surgery compared to a PAO alone. This research project will randomize patients to receive either a PAO alone, or a PAO and a hip arthroscopy at the same time.
Gender:
All
Ages:
Between 16 years and 50 years
Trial Updated:
01/02/2024
Locations: The Washington University, Saint Louis, Missouri
Conditions: Hip Dysplasia