Missouri is currently home to 1893 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Collaboration Oriented Approach to Controlling High Blood Pressure
NCT06124716
Recruiting
Hypertension is a significant contributor to poor cardiovascular outcomes. Self-management support tools can increase patient behaviors to improve blood pressure. The investigators created a clinical decision support app, called COACH, to integrate home blood pressure data and goals into EHR reporting and workflow with communications informed by behavioral economics principles to support shared decision-making. The study aims to measure the effectiveness of the COACH intervention in a pragmatic... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/22/2024
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Hypertension, Multiple Chronic Conditions
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The CALERIE™ Legacy Study
NCT05651620
Recruiting
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.
Gender:
ALL
Ages:
Between 33 years and 70 years
Trial Updated:
03/20/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Calorie Restriction
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Cardiac Markers in Depressed Patients With Coronary Heart Disease - R01HL147862
NCT04682769
Recruiting
Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and identify potential targets for their treatment. The results of the study will inform the development of more effective interventions to improve both depression and survival in pat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Coronary Heart Disease, Depression
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Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
NCT04028492
Recruiting
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/19/2024
Locations: Vanda Investigational Site, Chesterfield, Missouri
Conditions: Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
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Post-Market Feasibility Study of the Tenon Medical CATAMARAN™ SI Joint Fusion System
NCT05633888
Recruiting
The purpose of this study is to evaluate the outcomes of patients with sacroiliac joint pain treated with the CATAMARAN SI Joint Fusion System.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/18/2024
Locations: St. Louis Pain Consultants, Chesterfield, Missouri
Conditions: Sacroiliac Joint Disruption, Degenerative Sacroiliitis
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Single Ascending Dose of FXI-GalNAc-siRNA in Healthy Subjects
NCT05844293
Recruiting
The purpose of this study is to evaluate safety, tolerability, PK, and PD of SAD of FXI-GalNAc-siRNA administered SC to healthy subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/15/2024
Locations: BioPharma, Creve Coeur, Missouri
Conditions: FXI
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I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
NCT04488081
Recruiting
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: Mercy Hospital Springfield, Springfield, Missouri
Conditions: COVID-19
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Targeting Insomnia in School Aged Children With Autism Spectrum Disorder
NCT04545606
Recruiting
Children with Autism Spectrum Disorder (ASD) and insomnia, and their parent(s) will undergo 4 sessions of behavioral therapy for sleep problems followed by 4 bimonthly booster sessions. Children and their families will be randomly assigned to one of three conditions: cognitive behavioral therapy (in-person), cognitive behavioral therapy (remote), or behavioral therapy (remote). Arousal will be measured through heart-rate variability. Sleep and secondary outcomes (child daytime behavior, parent s... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
03/12/2024
Locations: Thompson Center for Autism and Neurodevelopmental Disorders, Columbia, Missouri
Conditions: Insomnia Chronic, Autism Spectrum Disorder
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The Role of Oxytocin in the Second Stage of Labor
NCT04303702
Recruiting
This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.
Gender:
FEMALE
Ages:
All
Trial Updated:
03/12/2024
Locations: Barnes Jewish Hospital, Saint Louis, Missouri
Conditions: Labor Complication
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AZD6738 for Patients With Progressive MDS or CMML
NCT03770429
Recruiting
This research study is studying a research drug called AZD6738 as a possible treatment for Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia .
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Leukemia, Myelodysplastic Syndrome
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Brain Stimulation for Severe Depression
NCT05393622
Recruiting
Chronic intracalvarial cortical stimulation is a minimally invasive method involving the neurosurgical placement of an electrode above the inner table of the skull. Over time, intracalvarial cortical stimulation is intermittently activated to modulate locally and distally connected brain regions. Because of the important role played by the dorsolateral prefrontal cortex in mood regulation, the goal of this study is to apply intracalvarial prefrontal cortical stimulation (IpCS) over the dorsolate... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
03/07/2024
Locations: Washington University in St Louis School of Medicine, Saint Louis, Missouri
Conditions: Depression Severe
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Evaluation of Symphony™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity
NCT04912674
Recruiting
Multi-center, prospective, non-randomized study to evaluate Symphony™ Posterior Cervical System in the setting of surgical treatment of adult cervical deformity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Cervical Deformity
Register for Updates