Missouri is currently home to 1929 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing Hypo-fractionated Intensity- Modulated Radiation Therapy to Standard- Fractionated IMRT Along With Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer
Recruiting
The hypothesis for this study is that hypofractionated IMRT to 62.5 Gy in 25 fractions (2.5 Gy/fraction) with concurrent carboplatin and paclitaxel, followed by maintenance durvalumab will improve locoregional control at 18 months by 10% compared to standard-fractionated chemo-IMRT/durvalumab. A modest improvement in locoregional control (LRC) was selected as a target which could merit further study of this hypofractionated IMRT regimen in a Phase III trial
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: The University of Kansas Cancer Center, North Clinic, Kansas City, Missouri
Conditions: Non Small Cell Lung Cancer Stage
Cannabis, HIV and Mental Processing Systems
Recruiting
This study employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. This study will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
12/04/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: HIV Infections, Cannabis
PET Detection of CCR2 in Human Atherosclerosis
Recruiting
: Use of novel radio-pharmaceutical 64CUDOTA-ECL1i to evaluate arterial atherosclrosis
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
12/04/2023
Locations: Washington University CCIR, Saint Louis, Missouri
Conditions: Carotid Atherosclerosis
Functional Imaging Reserve in NeuroHIV
Recruiting
The purpose of this research study is to look at the brain's efficiency and ability to make up for deficits in the front of the brain to see if people living with HIV (PLWH) are still able to perform well on various cognitive tasks even though there are other underlying processes at work, like inflammation, that affect the brain in a negative way. Results of this study may provide insight into the pathophysiology of disease and may reveal arenas for future possible interventions in PLWH who have... Read More
Gender:
All
Ages:
Between 20 years and 80 years
Trial Updated:
12/04/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: HIV
Investigations of Dementia in Parkinson Disease
Recruiting
The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.
Gender:
All
Ages:
50 years and above
Trial Updated:
12/04/2023
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Parkinsons
Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)
Recruiting
Chronic graft-versus-host disease (cGvHD) is one of the most serious complications following BMT (Bone Marrow Transplantation). cGvHD occurs when donor immune cells "attack" the tissues and organs of the person receiving the BMT. cGvHD can be difficult to treat once it is established leading to poor quality of life for recipients of a BMT. The goal of this study is to determine if, by using biomarkers, the investigators can predict which patients are at the highest risk of developing cGvHD after... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: Washington University St. Louis, Saint Louis, Missouri
Conditions: Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 Study
Recruiting
This study will validate a previously developed pediatric prognostic biomarker algorithm aimed at improving prediction of risk for the later development of chronic graft-versus-host disease (cGvHD) in children and young adults undergoing allogeneic hematopoietic stem cell transplant. By developing an early risk stratification of patients into low-, intermediate-, and high-risk for future cGvHD development (based upon their biomarker profile, before the onset of cGvHD), pre-emptive therapies aim... Read More
Gender:
All
Ages:
Between 0 years and 24 years
Trial Updated:
12/02/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Chronic Graft-versus-Host-Disease, Leukemia, Allogeneic Hematopoietic Stem Cell Transplantation, Blood Cancer, Non-Malignant Hematologic and Lymphocytic Disorder
Implementation of Ultrasound Guided Central Venous Catheter Confirmation Protocol
Recruiting
The bedside use of ultrasound after central venous catheter (CVCs) insertion has lagged behind other applications in medicine, thus presenting an opportunity for innovative, evidence-based research that will influence clinician behavior. This research focuses on bedside ultrasound applications as an example, to evaluate clinical practice change. Chest radiographs are associated with delays in initiating time-critical interventions and present an unexamined opportunity for improving patient care... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/01/2023
Locations: Washington Unversity School Of Medicine, Saint Louis, Missouri
Conditions: Behavior, Process, Acceptance, Inertia of Accommodation
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Kansas City Research Institute, Kansas City, Missouri
Conditions: Non-Alcoholic Fatty Liver Disease
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
Recruiting
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the study.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Missouri - Columbia, Columbia, Missouri
Conditions: Tobacco Use Disorder
The Pediatric Anesthesia Quality Improvement Project
Recruiting
The Study is designed to collect information about adverse events that occur in children undergoing anesthesia in participating hospitals. Demographic information will be collected on all anesthetics. An analysis of each adverse event will be performed and entered into the database. From this information we will devise strategies to prevent these adverse events.
Gender:
All
Ages:
21 years and below
Trial Updated:
11/20/2023
Locations: SSM Cardinal Glennon Health Care System, Saint Louis, Missouri
Conditions: Surgery, Anesthesia, Children
Connect® Lymphoma Disease Registry: A US-Based Prospective Observational Cohort Study
Recruiting
The Connect® Lymphoma Disease Registry is a US-based, multicenter, prospective observational (non-interventional) cohort study designed to collect real-world, participant-level data longitudinally in participants diagnosed with various subtypes of non-Hodgkin lymphoma (NHL).
Gender:
All
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Harry S. Truman Memorial Veterans' Hospital (HSTMVH) - NAVREF - PPDS, Columbia, Missouri
Conditions: Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular