Missouri is currently home to 1932 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
NCT03713424
Recruiting
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the study.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Missouri - Columbia, Columbia, Missouri
Conditions: Tobacco Use Disorder
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The Pediatric Anesthesia Quality Improvement Project
NCT00674388
Recruiting
The Study is designed to collect information about adverse events that occur in children undergoing anesthesia in participating hospitals. Demographic information will be collected on all anesthetics. An analysis of each adverse event will be performed and entered into the database. From this information we will devise strategies to prevent these adverse events.
Gender:
All
Ages:
21 years and below
Trial Updated:
11/20/2023
Locations: SSM Cardinal Glennon Health Care System, Saint Louis, Missouri
Conditions: Surgery, Anesthesia, Children
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Connect® Lymphoma Disease Registry: A US-Based Prospective Observational Cohort Study
NCT04982471
Recruiting
The Connect® Lymphoma Disease Registry is a US-based, multicenter, prospective observational (non-interventional) cohort study designed to collect real-world, participant-level data longitudinally in participants diagnosed with various subtypes of non-Hodgkin lymphoma (NHL).
Gender:
All
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Harry S. Truman Memorial Veterans' Hospital (HSTMVH) - NAVREF - PPDS, Columbia, Missouri
Conditions: Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular
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ADPKD Patient Registry
NCT04039061
Recruiting
The purpose of the ADPKD Registry is to create an online patient network that includes at least 5,000 people with Autosomal Dominant Polycystic Kidney Disease (ADPKD) who contribute data on their health and other topics. The ADPKD Patient Registry aims to support important scientific discoveries and support patient needs in the following ways: Connect ADPKD patients with opportunities to join clinical studies. Collect data for the research community to better describe the ADPKD disease experien... Read More
Gender:
All
Ages:
All
Trial Updated:
11/15/2023
Locations: PKD Foundation, Kansas City, Missouri
Conditions: Polycystic Kidney Diseases
Register for Updates
Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA
NCT05855083
Recruiting
The purpose of this study is to evaluate the safety and efficacy of narsoplimab in pediatric patients with thrombotic microangiopathies (TMA) following hematopoietic stem cell transplant (HSCT).
Gender:
All
Ages:
Between 28 days and 17 years
Trial Updated:
11/14/2023
Locations: Omeros Investigational Site, Saint Louis, Missouri
Conditions: Thrombotic Microangiopathies, Hematopoietic Stem Cell Transplantation
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7-Day Trial of Sucraid for Alleviating CSID Symptoms in Subjects With Low, Moderate, and Normal Sucrase Levels
NCT05480761
Recruiting
This is a Phase 4, U.S. only, multi-center study using a 7-day therapeutic response dose (TRD) of commercial Sucraid® to assess the response of treatment in 1100 symptomatic pediatric (6 months to 17 years old) subjects with low, moderate, and normal sucrase activity determined by a disaccharidase assay via EGD within 1 year of the Screening Visit. This study will also explore the relationship between known genetic CSID mutations and sucrase activities via (EGD) disaccharidase assay (low, modera... Read More
Gender:
All
Ages:
Between 6 months and 17 years
Trial Updated:
11/14/2023
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Congenital Sucrase-Isomaltase Deficiency, CSID, Sucrase Isomaltase Deficiency
Register for Updates
A Prospective Analysis of Long-Term Clinical Outcomes and 3D Spine Growth in Anterior Vertebral Body Tethering
NCT04914507
Recruiting
Anterior vertebral body tethering (AVBT) is a novel, minimally invasive, growth modulation technique that was recently approved by the FDA under a Humanitarian Device Exemption (HDE). The goal of AVBT is to control curve progression by applying compression on the convex side of the spine deformity. While there has been great initial enthusiasm about the technique as an alternate treatment option to spinal fusion for skeletally immature children with scoliosis, there is a need to better understan... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
11/14/2023
Locations: Washington University, Saint Louis, Missouri
Conditions: Scoliosis Idiopathic
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Group CBT in Parents of Children With Food Allergy
NCT06138431
Recruiting
Parents of children with food allergies that are medically established will be randomized to participate either in 6 one-hour weekly virtual Cognitive Behavioral Therapy (CBT) groups or to a wait-list group, and outcomes will be measured for anxiety, depression and quality of life. Possible benefits include improvement in psychological functioning and quality of life of families, as well as improved understanding of the use of group Cognitive Behavioral Therapy (CBT) for parents of children with... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/13/2023
Locations: University Health Behavioral Health Canvas Building, Kansas City, Missouri
Conditions: Parents
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Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants
NCT05547165
Recruiting
Patent Ductus Arteriosus is a developmental condition commonly observed among preterm infants. It is a condition where the opening between the two major blood vessels leading from the heart fail to close after birth. In the womb, the opening (ductus arteriosus) is the normal part of the circulatory system of the baby, but is expected to close at full term birth. If the opening is tiny, the condition can be self-limiting. If not, medications/surgery are options for treatment. There are two ways... Read More
Gender:
All
Ages:
Between 7 days and 32 days
Trial Updated:
11/12/2023
Locations: St. Louis Children's Hospital, Saint Louis, Missouri
Conditions: Ductus Arteriosus, Patent
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Treatment of PAF With the Synaptic System
NCT05905835
Recruiting
Enrolled subjects will be treated with the Synaptic Cryoablation System. Treatment will include cryoablation of the pulmonary veins to achieve PVI. All subjects will be followed for twelve (12) months after completion of the index ablation procedure.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/09/2023
Locations: St. Luke's Mid America, Kansas City, Missouri
Conditions: Paroxysmal Atrial Fibrillation
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Spinal Cord Stimulation and Training
NCT05472584
Recruiting
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.
Gender:
All
Ages:
Between 16 years and 65 years
Trial Updated:
11/07/2023
Locations: Washington University, Saint Louis, Missouri
Conditions: Spinal Cord Injuries
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Amitriptyline for Repetitive Behaviors in Autism Spectrum Disorders
NCT04725383
Recruiting
The investigators will recruit 30 children and adolescents (15 per group x 2 groups) aged 6 to 17 years with ASD and significant repetitive behaviors that cause problems to them and to others around them. Subjects will be randomized to either amitriptyline (AMI), dosed flexibly according to response and tolerability with a maximum dose of 100mg per day or 1.5mg/kg/day, in divided doses to minimize side effects, or placebo in look-alike capsules, for 10 weeks. Rating scales will be used to measur... Read More
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
11/02/2023
Locations: University Health Behavioral Health Canvas Building, Kansas City, Missouri
Conditions: Autism Spectrum Disorder, Repetitive Compulsive Behavior
Register for Updates