Missouri is currently home to 1891 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Personalized Prediction of Persistent Postsurgical Pain
NCT04864275
Recruiting
P5 is planned as a prospective observational study, collecting evidence-based perioperative data on patient history and demographics, physical function, cognitive measures, psychological, and biological markers associated with increased pain susceptibility, and psychophysical measures of pain processing. The study will use daily ecologic momentary assessment (EMA) of physical and emotional parameters, and collect data on perioperative events. Follow up will occur 3 months and 6 months postoper... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2024
Locations: Washington University in St Louis, Saint Louis, Missouri
Conditions: Pain, Postoperative
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Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
NCT04137900
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
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Role of Novel ILR in the Management of PVCs
NCT06060548
Recruiting
This prospective, observational study is a single center clinical registry of patients referred for management of symptomatic or asymptomatic Premature Ventricular Contractions (PVCs). Subjects will be followed through 12 months. The study will enroll approximately 50 patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2024
Locations: Centerpoint Medical Center Clinic, Independence, Missouri
Conditions: PVC - Premature Ventricular Contraction, Myocarditis
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Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)
NCT04296864
Recruiting
This is a multi-center, double-masked, randomized, placebo-controlled, parallel-group, efficacy, safety, and tolerability study evaluating the efficacy of Dupilumab in the treatment of signs and symptoms of atopic keratoconjunctivitis (AKC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Silverstein Eye Centers, Kansas City, Missouri
Conditions: Atopic Keratoconjunctivitis
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RCT Evaluating Standardized Counseling on Early Discontinuation for Irregular Bleeding in Nexplanon Users
NCT04558229
Recruiting
Clinician counseling for implant users should involve an explanation of the likelihood of irregular bleeding and the possibility of continued or frequent bleeding throughout three years of use. If that counseling does not provide specifics of the actual distribution of bleeding patterns described in published literature, there remains the real possibility of biased or directed counseling, leading to an inaccurate and exaggerated expectation of potential bleeding changes. This study aims to evalu... Read More
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
01/28/2024
Locations: Planned Parenthood of the St. Louis Region and Southwest Missouri, Saint Louis, Missouri
Conditions: Birth Control, Contraception, Contraceptive Usage, Family Planning
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Galen Research, Chesterfield, Missouri
Conditions: NASH - Nonalcoholic Steatohepatitis
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An Efficient Treatment for Posttraumatic Injury for Firefighters
NCT05950035
Recruiting
The goal of this two-arm pilot randomized controlled trial is to test a behavioral intervention that integrates three evidence-based cognitive behavioral interventions (written exposure therapy; WET, cognitive behavioral therapy for insomnia; CBT-I, and cognitive behavioral therapy for nightmares; CBT-N) among firefighters. The main questions it aims to answer are: * Is the behavioral intervention feasible, acceptable, and effective in reducing symptoms of posttraumatic stress, insomnia, and ni... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/23/2024
Locations: NDRI_USA, Kansas City, Missouri
Conditions: Posttraumatic Stress Disorder, Insomnia, Nightmare
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Investigation of Inflammation in Alzheimer's Disease and Related Dementias (ADRD) Using [11C]-CS1P1
NCT06129838
Recruiting
This study involves a brain positron emission tomography (PET) scan with a new, investigational radioactive tracer called \[11C\]-CS1P1 to identify inflammation in the brain by testing with healthy older adults and with cognitively impaired older adults.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
01/12/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Alzheimer Disease
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Imaging Biomarkers in Preclinical and Symptomatic AD
NCT04134923
Recruiting
The purpose of this research study is to evaluate adult children of parents with and without Alzheimer's disease which represent an ideal population for investigating the biological changes that precede the clinical onset of AD. The investigators will be imaging the brain to detect the presence of amyloid deposits (plaques in the brain). Amyloid is a protein that may be related to dementia of Alzheimer's disease (DAT).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/12/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Alzheimer Disease
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C-Brace Prospective Registry
NCT04640584
Recruiting
To gather prospective safety and effectiveness data for the C-Brace System following the standard of care.
Gender:
ALL
Ages:
All
Trial Updated:
01/09/2024
Locations: P&O Care x Ottobock.care, Saint Louis, Missouri
Conditions: Pareses, Lower Extremity
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Telehealth as a Modality to Increase the Uptake of PrEP Services in Black and Latino: "e-PrEP"
NCT05528653
Recruiting
To evaluate if utilizing Telehealth medicine for access to HIV PrEP will engage more Black and Latino Men who have sex with Men (MSM)
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/03/2024
Locations: Vivent Health, Saint Louis, Missouri
Conditions: HIV Prevention
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Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology
NCT03481010
Recruiting
At present, it is not clear whether performing a hip arthroscopy at the same time as a PAO improves patient outcomes after surgery compared to a PAO alone. This research project will randomize patients to receive either a PAO alone, or a PAO and a hip arthroscopy at the same time.
Gender:
ALL
Ages:
Between 16 years and 50 years
Trial Updated:
01/02/2024
Locations: The Washington University, Saint Louis, Missouri
Conditions: Hip Dysplasia
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