Missouri is currently home to 1899 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Comparing the Effectiveness of Two Produce Prescription Approaches On Fruit and Vegetable Intake and Food Security, While Exploring Implementation Outcomes Such as Reach, Implementation, Sustainability, and Cost
NCT06263751
Recruiting
The produce prescription program is one type of food is medicine (FIM) programs, where healthcare providers "prescribe" fruits and vegetables (F\&V) to patients with low household incomes, experience food insecurity, and one or more diet-related diseases. NutriConnect seeks to compare the effectiveness of two produce prescription approaches on F\&V intake and food security: credit to Rewards account (NutriConnect Credit) vs. produce box delivery (NutriConnect Delivery), while exploring implement... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/25/2024
Locations: Barnes Jewish Hospital, Saint Louis, Missouri
Conditions: Food Insecurity
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Functional Outcomes From Diets in Multiple Sclerosis
NCT05327322
Recruiting
The purpose of this study is to test the effects of two dietary interventions, glycemic load and calorie restriction, on physical function, cognition, pain, fatigue, mood, and anxiety in adults with multiple sclerosis (MS). The investigators will also explore the how the diet interventions impact inflammation, immunity, and metabolic biomarkers.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/25/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
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Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
NCT04703842
Recruiting
It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to improved clinical outcomes. Additionally, it is hypothesized that correcting SERCA2a dysfunction will also improve coronary blood flow through correction of the impaired endothelium-dependent nitric oxide-mediated vasodilatation observed in heart failure.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/24/2024
Locations: Washington University in Saint Louis, Saint Louis, Missouri
Conditions: Congestive Heart Failure, Heart Failure, Systolic, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction
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Collaboration Oriented Approach to Controlling High Blood Pressure
NCT06124716
Recruiting
Hypertension is a significant contributor to poor cardiovascular outcomes. Self-management support tools can increase patient behaviors to improve blood pressure. The investigators created a clinical decision support app, called COACH, to integrate home blood pressure data and goals into EHR reporting and workflow with communications informed by behavioral economics principles to support shared decision-making. The study aims to measure the effectiveness of the COACH intervention in a pragmatic... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/22/2024
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Hypertension, Multiple Chronic Conditions
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The CALERIE™ Legacy Study
NCT05651620
Recruiting
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.
Gender:
ALL
Ages:
Between 33 years and 70 years
Trial Updated:
03/20/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Calorie Restriction
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Cardiac Markers in Depressed Patients With Coronary Heart Disease - R01HL147862
NCT04682769
Recruiting
Depression doubles the risk of death in patients with coronary heart disease (CHD), but so far, there is insufficient evidence that we can reduce the risk of death by treating depression. This study will investigate the cardiac risk markers that are associated with depression symptoms that remain despite treatment, and identify potential targets for their treatment. The results of the study will inform the development of more effective interventions to improve both depression and survival in pat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Coronary Heart Disease, Depression
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Post-Market Feasibility Study of the Tenon Medical CATAMARAN™ SI Joint Fusion System
NCT05633888
Recruiting
The purpose of this study is to evaluate the outcomes of patients with sacroiliac joint pain treated with the CATAMARAN SI Joint Fusion System.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/18/2024
Locations: St. Louis Pain Consultants, Chesterfield, Missouri
Conditions: Sacroiliac Joint Disruption, Degenerative Sacroiliitis
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Single Ascending Dose of FXI-GalNAc-siRNA in Healthy Subjects
NCT05844293
Recruiting
The purpose of this study is to evaluate safety, tolerability, PK, and PD of SAD of FXI-GalNAc-siRNA administered SC to healthy subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/15/2024
Locations: BioPharma, Creve Coeur, Missouri
Conditions: FXI
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I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
NCT04488081
Recruiting
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a big impact on reducing mortality and the need for, as well as duration, of mechanical ventilation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: Mercy Hospital Springfield, Springfield, Missouri
Conditions: COVID-19
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Targeting Insomnia in School Aged Children With Autism Spectrum Disorder
NCT04545606
Recruiting
Children with Autism Spectrum Disorder (ASD) and insomnia, and their parent(s) will undergo 4 sessions of behavioral therapy for sleep problems followed by 4 bimonthly booster sessions. Children and their families will be randomly assigned to one of three conditions: cognitive behavioral therapy (in-person), cognitive behavioral therapy (remote), or behavioral therapy (remote). Arousal will be measured through heart-rate variability. Sleep and secondary outcomes (child daytime behavior, parent s... Read More
Gender:
ALL
Ages:
Between 6 years and 12 years
Trial Updated:
03/12/2024
Locations: Thompson Center for Autism and Neurodevelopmental Disorders, Columbia, Missouri
Conditions: Insomnia Chronic, Autism Spectrum Disorder
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The Role of Oxytocin in the Second Stage of Labor
NCT04303702
Recruiting
This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.
Gender:
FEMALE
Ages:
All
Trial Updated:
03/12/2024
Locations: Barnes Jewish Hospital, Saint Louis, Missouri
Conditions: Labor Complication
Register for Updates
AZD6738 for Patients With Progressive MDS or CMML
NCT03770429
Recruiting
This research study is studying a research drug called AZD6738 as a possible treatment for Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia .
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: Washington University, Saint Louis, Missouri
Conditions: Leukemia, Myelodysplastic Syndrome
Register for Updates