Missouri is currently home to 2002 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
NCT05267821
Recruiting
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Gender:
All
Ages:
Between 1 day and 17 years
Trial Updated:
02/07/2023
Locations: Mercy Children's Hospital, Kansas City, Missouri
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study
NCT05610787
Recruiting
The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Driving System while being used with the approved EXCOR Pediatric Ventricular Assist Device. EXCOR Active Driving System is intended for use with the approved EXCOR Pediatric VAD. The EXCOR Pediatric VAD is intended to provide mechanical circulatory support as a bridge to cardiac transplantation for pediatric patients. Pediatric candidates with severe isolat... Read More
Gender:
All
Ages:
21 years and below
Trial Updated:
02/06/2023
Locations: St Louis Children's Hospital, Saint Louis, Missouri
Conditions: Heart Failure, Transplant; Failure, Heart, Congenital Heart Disease
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The PROMISE Study: Duavee in Women With DCIS
NCT02694809
Recruiting
The main purpose of this study is to determine if taking the study drug, conjugated estrogens/bazedoxifene (Duavee®) causes any changes in the proliferation markers within the breast tissue of the study subjects. The study drug is approved by the US Food and Drug Administration in healthy postmenopausal women to treat certain symptoms of menopause such as hot flashes. Since it is not approved in women with DCIS, its use in this study is experimental. This study will also look at whether taking t... Read More
Gender:
Female
Ages:
Between 18 years and 79 years
Trial Updated:
02/06/2023
Locations: Washington University in St. Louis/ Siteman Cancer Center, Saint Louis, Missouri
Conditions: Ductal Breast Carcinoma In Situ, Postmenopausal
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Apixaban for the Acute Treatment of Venous Thromboembolism in Children
NCT02464969
Recruiting
To assess the safety and descriptive efficacy of apixaban in pediatric subjects requiring anticoagulation for the treatment of a VTE.
Gender:
All
Ages:
Between 0 days and 17 years
Trial Updated:
02/06/2023
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Venous Thromboembolism
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Masitinib for the Treatment of Severe Mast Cell Activation Syndrome
NCT05449444
Recruiting
To evaluate the efficacy and safety of two dosing schemes of oral masitinib versus matching placebo in the treatment of patients suffering from severe MCAS with handicap unresponsive to optimal symptomatic treatment.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/03/2023
Locations: St Charles Clinical Research, Weldon Spring, Missouri
Conditions: Mast Cell Activation Syndrome
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CORRECT Study of Minimal Residual Disease Detection in Colorectal Cancer
NCT05210283
Recruiting
The CORRECT - MRD II study will prospectively enroll patients who have undergone complete surgical resection for stage II or III colorectal cancer. Patients will be followed for a minimum of 3 years and up to 5 years for recurrence.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2023
Locations: Missouri Baptist Medical Center, Saint Louis, Missouri
Conditions: Colorectal Cancer
Register for Updates
Repetitive TMS & Cognitive Training in Adults With Schizophrenia
NCT03741751
Recruiting
The proposed project aims to establish the feasibility and tolerability of delivering repetitive transcranial magnetic stimulant (rTMS) combined with computerized cognitive training in patients with Schizophrenia or Schizoaffective Disorder and cognitive difficulties. The investigators will conduct a 2 week randomized controlled trial study evaluating computerized cognitive training combined with either active or sham rTMS on cognitive and functional outcomes in adults with Schizophrenia or Sch... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/01/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders, Cognitive Impairment
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Cemented vs Cementless TKA
NCT03683992
Recruiting
The purpose of this study is to compare cemented and cementless versions of the Triathlon total knee arthroplasty/replacement (TKA) in terms of clinical outcomes, perioperative course, and outcome scores including function and patient satisfaction. Patients who present to the clinical practices of Dr. Ryan Nunley, Dr. Robert Barrack, or Dr. Denis Nam and are suitable candidates for primary TKA will be screened for eligibility and invited to participate. Once enrolled participants will be random... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/01/2023
Locations: Washington University Medical School, Saint Louis, Missouri
Conditions: Knee Osteoarthritis
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Vigabatrin and Insulin Sensitivity
NCT04321395
Recruiting
Nonalcoholic fatty liver disease (NAFLD) is a common complication of obesity and is associated with an increased risk of developing type 2 diabetes. The hallmark feature of NAFLD is an increase in intrahepatic triglyceride (IHTG) content. Data from studies conducted in rodent models suggest increased IHTG content can alter hepatic vagal afferent nerve (HVAN) activity. In rodent models of obesity and NAFLD, HVAN activity is reduced leading to impaired insulin sensitivity and glucose control. The... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/31/2023
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: NAFLD, Obesity
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Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer
NCT05638698
Recruiting
Researchers want to discover if the new drug "TG01" will work with participants' bodies to help their immune system attack any cancer cells that might still be in the blood stream after surgery for pancreatic cancer. The researchers will also investigate whether or not "TG01" combined with the other study drug, "Balstilimab", will show even greater efficacy. TG01 and Balstilimab are both experimental treatments and are not approved by the US Food and Drug Administration (FDA) as treatment in t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: University of Kansas Cancer Center - North, Kansas City, Missouri
Conditions: Pancreas Cancer
Register for Updates
Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors
NCT02372409
Recruiting
By employing a combination of advanced MRI techniques and correlative serum biomarkers of blood brain barrier (BBB) disruption, the investigators plan to develop a powerful, first of its kind clinical algorithm in pediatrics whereby the investigators can measure and identify the window of maximal BBB disruption post MLA to 1) allow for an alternative to surgery in incompletely resected tumors, 2) allow for optimal chemotherapeutic dosing to achieve the greatest benefits and the least systemic si... Read More
Gender:
All
Ages:
Between 3 years and 21 years
Trial Updated:
01/29/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Glioma, Pilocytic Astrocytoma, Anaplastic Astrocytoma, Glioblastoma, Mixed Oligoastrocytoma, Mixed Glioma, Oligodendroglioma, Optic Glioma, Astrocytoma
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Cerebral Oxygen Metabolism in Children
NCT04157179
Recruiting
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. We will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels can do varies by age. The brain's blood flow changes in small ways during everyday activities, su... Read More
Gender:
All
Ages:
Between 3 years and 50 years
Trial Updated:
01/27/2023
Locations: Washington University of St. Louis, Saint Louis, Missouri
Conditions: Sickle Cell Disease, Cerebral Stroke
Register for Updates