Missouri is currently home to 2009 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Saint Louis, Kansas City, St. Louis and Springfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Treatment Of Atrial Fibrillation In Preserved Cardiac Function Heart Failure
NCT04160000
Recruiting
Heart failure (HF) with preserved left ventricular function (pEF) is difficult clinical syndrome to treat effectively with few evidence based therapies. Atrial fibrillation (AF) is now an important co-morbidity being observed in 43% of patients with HFpEF. Rhythm control has not been studied in this population. Catheter ablation and antiarrhythmic drugs are rhythm control therapies that have been used for treatment of AF without HF or HF with reduced systolic function but have not been widely ap... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/18/2022
Locations: Kansas City Heart Rhythm Institute, Overland, Missouri
Conditions: Atrial Fibrillation, Heart Failure, Diastolic Heart Failure
Register for Updates
Safety and Effectiveness of Placental Derived Exosomes and Umbilical Cord Mesenchymal Stem Cells in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) Associated With the Novel Corona Virus Infection (COVID-19)
NCT05387278
Recruiting
Recent advances have been made in prevention of the viral infection via vaccines but there is still need for effective treatment options for patients. Novel therapies need to be developed to further improve clinical outcomes. The biggest medical challenge in the response to COVID-19 is ARDS requiring hospitalization in an intensive care setting and ventilator dependence. Intravenously administered umbilical cord derived exosomes and stem cells have been reported in literature to alleviate pulmon... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
10/11/2022
Locations: Kit Bartalos, Liberty, Missouri
Conditions: COVID-19 Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome
Register for Updates
Sleep Treatment for Addiction Recovery
NCT04198311
Recruiting
Project STAR aims to examine the feasibility, acceptability, and initial efficacy of a CBT-I supplement to outpatient alcohol and substance use treatment.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/06/2022
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Insomnia, Alcohol Use Disorder, Substance Use Disorders
Register for Updates
Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study)
NCT05570448
Recruiting
This will be a randomized clinical trial examining the efficacy and safety of ARAT (intervention group) in patients with chronic GERD symptoms (typical symptoms of GERD, i.e. heartburn or acid reflux/regurgitation at least twice a week) for the last 6 months. Patients must have a positive pH test and a negative manometry (no treatment) procedure.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/05/2022
Locations: Kansas City VA Hospital, Kansas City, Missouri
Conditions: Gastro Esophageal Reflux
Register for Updates
PET Imaging CCR2 in Lung Inflammation
NCT03492762
Recruiting
The primary objective of this study is to assess the lung distribution of the Positron Emission Tomography (PET) imaging radiotracer Cu-DOTA-ECL1i, which binds to the specific population inflammatory cells, in patients with fibrotic lung diseases. This objective includes sub-studies to assess radiotracer distribution in the lung, the reproducibility of PET scans and the relationship of the scan to distribution of inflammatory cells in human lung tissue. The overall goal is to assess the potentia... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
10/03/2022
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Lung Inflammation
Register for Updates
Ovarian Morphology in Girls
NCT04424576
Recruiting
Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being. Irregular menstrual cycles are especially common for the first 2-3 years after an adolescent's first menstrual period (i.e., menarche), which delays the identification and diagnosis of early reproductive disturbances such as polycystic ovary syndrome (PCOS). The purpose of this research study is to determine whether the ovary can serve as a reliable predi... Read More
Gender:
Female
Ages:
Between 9 years and 17 years
Trial Updated:
09/23/2022
Locations: Children's Mercy Hospital, Kansas City, Missouri
Conditions: Amenorrhea, Oligomenorrhea, Puberty
Register for Updates
Late Onset Alzheimer's Disease
NCT05010603
Recruiting
The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.
Gender:
All
Ages:
55 years and above
Trial Updated:
09/16/2022
Locations: Joanne Norton, Saint Louis, Missouri
Conditions: Alzheimer Disease
Register for Updates
Rare and Atypical Diabetes Network
NCT05544266
Recruiting
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical di... Read More
Gender:
All
Ages:
All
Trial Updated:
09/14/2022
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
Register for Updates
Effects of Microplegia on Transfusion Rates After Cardiac Surgery
NCT05076604
Recruiting
This is a prospective, randomized study that is studying the rate of red blood cell (RBC) transfusion rates after planned heart (cardiac) surgery. The study will be conducted at Barnes-Jewish Hospital. Cardioplegia refers to the method of stopping (arresting) the heart in order to perform heart surgery. However, cardioplegia has also come to refer to the solution to achieve cardiac arrest as well as the machinery in which to deliver the solution. This study will investigate our current Standard... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/13/2022
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Aortic Valve Disease, Mitral Valve Disease
Register for Updates
CODY: A Study Evaluating The Safety And Efficacy Of QTORIN 3.9% Sirolimus Topical Gel For The Prevention Of Basal Cell Carcinomas (BCCs) In Patients With Gorlin Syndrome
NCT04893486
Recruiting
A Phase 2b study looks at the safety and efficacy of a treatment that is being investigated for people with certain diseases. This study will be conducted at multiple centers in the United States where participants with Gorlin Syndrome, also known as basal cell nevus syndrome, will be randomly placed into two groups; one group will receive the active topical gel, the other a topical vehicle gel, also know as placebo. Participants will apply this topical product to their face once a day for 6 mon... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/26/2022
Locations: St. Louis University, Saint Louis, Missouri
Conditions: BCCs in Gorlin Syndrome Patients
Register for Updates
NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Chemical and/or Thermal Injuries
NCT04081103
Recruiting
This study will enroll participants with a non-infected, corneal persistent epithelial defect (PED) resulting from an ocular chemical and/or thermal ocular injury which is non-responsive or refractory to current standard of care for at least 14 days. It will assess the efficacy and safety of Nexagon® (lufepirsen) plus standard of care versus NEXAGON-vehicle (placebo) plus standard of care. The recovery of the corneal epithelium will be the primary outcome measure, defined as a cornea that re-epi... Read More
Gender:
All
Ages:
All
Trial Updated:
08/25/2022
Locations: Mercy Eye Care, Springfield, Missouri
Conditions: Corneal Persistent Epithelial Defect
Register for Updates
Diastolic Hyperemia Free Index for Assessment of Moderate Coronary Stenoses
NCT04019535
Recruiting
A total of 106 subjects will be enrolled at up to 3 sites. Initial enrollment will occur at Washington University only. After 15 subjects have been enrolled at the primary site and no serious adverse events or protocol events have occurred the additional sites will be trained and added to enrollment.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/22/2022
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Coronary Artery Disease
Register for Updates