Nebraska is currently home to 717 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Omaha, Lincoln, Kearney and Grand Island. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Continuous Treatment With PREVENA Therapy for 14 Days
NCT05614869
Recruiting
The purpose of this study is to demonstrate substantial equivalence in terms of safety to support an indication change related to the usage of Prevena Therapy for up to 14 days. The enrolled subject will undergo 1 of 4 surgery types and be evaluated for up to 90 days.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/14/2024
Locations: Bryan Heart, Lincoln, Nebraska
Conditions: Abdominal Surgery, Orthopedic Surgery, Cardiovascular Surgery, Vascular Surgery
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ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
NCT05021835
Recruiting
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Z... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/12/2024
Locations: Nebraska Heart Institute_Lincoln, Lincoln, Nebraska
Conditions: Cardiovascular Risk, Chronic Kidney Disease, Inflammation
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Impella RP Flex with Smart Assist
NCT06637644
Recruiting
To capture observational data of the Abiomed Impella RP Flex in a real-world setting.
Gender:
ALL
Ages:
All
Trial Updated:
10/09/2024
Locations: University of Nebraska Medical Center, Omaha, Nebraska
Conditions: Right Ventricular (RV) Dysfunction
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Iberdomide Maintenance Therapy in Patients With Multiple Myeloma
NCT05177536
Recruiting
This study will determine the feasibility, safety and efficacy of iberdomide maintenance therapy post-autologous stem cell transplant (ASCT). Treatment will continue until disease progression or toxicity. The results from this study will inform the feasibility of pursuing a study comparing iberdomide to lenalidomide maintenance post-ASCT.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/09/2024
Locations: University of Nebraska Medical Center, Omaha, Nebraska
Conditions: Multiple Myeloma
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XmAb®20717 (Vudalimab) Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer
NCT05005728
Recruiting
This Phase 2 study will investigate the safety and clinical activity of vudalimab (XmAb20717) alone or in combination with standard of care anticancer therapies in patients with metastatic castration-resistant prostate cancer (mCRPC) who have progressed on prior therapy.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: GU Research Network/Urology Cancer Center, Omaha, Nebraska
Conditions: Metastatic Castration-Resistant Prostate Cancer
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Comparison of Gait in Syndesmosis Injuries Treated With Screw Fixation vs Suture Button
NCT04972578
Recruiting
Injuries to the distal tibiofibular syndesmosis are common and occur in an estimated 25% of all rotational ankle fractures. Anatomic reduction of the syndesmosis has been associated with improved functional outcome as well as decreased rates of posttraumatic arthritis. Both screw fixation and suture fixation have become accepted standards of care for treatment of syndesmotic injuries. Recent literature would suggest trends favoring suture fixation over screw fixation with improved quality of syn... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
10/01/2024
Locations: Nebraska Medicine, Bellevue Health Center, Bellevue, Nebraska
Conditions: Acute Disruption of Ankle Syndesmosis
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Behavioral Economic & Staffing Strategies in the ICU
NCT06184945
Recruiting
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically evaluate two discrete strategies grounded in behavioral economic and implementation science theory (i.e., real-time audit and feedback and registered nurse implementation facilitation) to increase adopt... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
09/30/2024
Locations: University of Nebraska Medical Center, Omaha, Nebraska
Conditions: Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication, ICU Acquired Weakness, Pain
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High-dose Brachytherapy Boost With Stereostatic Body Radiation Therapy to Intermediate or Higher Risk Prostate Cancer
NCT05754580
Recruiting
The objective of this phase I/II trial is to prospectively evaluate the toxicity and therapeutic efficacy of Stereostatic Body Radiation Therapy (SBRT) to prostate and pelvic lymph nodes in combination with high-dose-rate (HDR) brachytherapy to the prostate in patients with localized unfavorable-intermediate risk or higher disease.
Gender:
MALE
Ages:
19 years and above
Trial Updated:
09/30/2024
Locations: University of Nebraska Medical Center, Omaha, Nebraska
Conditions: Prostatic Cancer
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A Longitudinal Observational Study of Patients Undergoing Therapy for IMISC
NCT03661866
Recruiting
TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice. TARGET-DERM will create a research registry of patients with IMISC within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.
Gender:
ALL
Ages:
All
Trial Updated:
09/26/2024
Locations: South Lincoln Dermatology Clinic, Lincoln, Nebraska
Conditions: Atopic Dermatitis, Hidradenitis Suppurativa, Vitiligo, Psoriasis, Alopecia Areata, Chronic Spontaneous Urticaria
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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC61in Subjects With Advanced Solid Tumors
NCT05287399
Recruiting
This is a Phase 1, open-label, multicenter, single-arm, dose escalation study, designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of single-agent ASC61(an orally bioavailable small-molecule inhibitor of PD-L1) in subjects with advanced solid tumors for whom no standard therapy is available.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: Nebraska Cancer Specialists, Omaha, Nebraska
Conditions: Advanced Solid Tumors
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Exoskeleton Variability Optimization
NCT04338815
Recruiting
The investigators will evaluate a potentially faster and more clinically feasible method to optimize exoskeletons in pilot tests in healthy in preparation for patients with peripheral artery disease.
Gender:
ALL
Ages:
Between 19 years and 85 years
Trial Updated:
09/25/2024
Locations: University of Nebraska Omaha, Omaha, Nebraska
Conditions: Peripheral Arterial Disease
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A Phase 3B Study to Evaluate Bone Mineral Density with Long-Term Use of Relugolix Combination Tablet in Women with Uterine Fibroids or Endometriosis
NCT05862272
Recruiting
The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in premenopausal women with heavy menstrual bleeding associated with uterine leiomyomas (fibroids) or with moderate-to-severe pain associated with endometriosis.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
09/24/2024
Locations: Grand Island, Grand Island, Nebraska
Conditions: Uterine Fibroids, Endometriosis
Register for Updates