The state of North Carolina currently has 20 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Durham, Winston-Salem, Charlotte and Chapel Hill.
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
06/18/2024
Locations: New Dawn Psychiatric Services PLLC /ID# 229782, Kinston, North Carolina
Conditions: Depression, Bipolar I Disorder
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Recruiting
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving wellbeing after surgery.
Gender:
Female
Ages:
18 years and above
Trial Updated:
06/06/2024
Locations: Atrium Health - Levine Cancer Institute, Charlotte, North Carolina +1 locations
Conditions: Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance, Malignant Female Reproductive System Neoplasm
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
Recruiting
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are: What are the obstacles to enrolling patients and prescribing anti-depressants among older adults? Is it possible to start prescribing SNRI medication upon discharge? What is the prevalence of depressive symptoms amongst patients with different types of injuries and w... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
05/31/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Depression in Old Age, Fragility Fracture
Psilocybin-Assisted Therapy in Treatment-Resistant Depression
Recruiting
The goal of this clinical trial is to test how well psilocybin-assisted therapy works in treating people with depression. The main questions this study aims to answer are: Does psilocybin with assisted therapy help improve symptoms for people with depression? How long do the effects of this treatment last? Participants will: Take part in a couple of screening and preparation visits. Be given psilocybin in one or two treatment sessions. Attend a series of follow-up sessions over the following... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/28/2024
Locations: UNC Chapel Hill Medical Center, Chapel Hill, North Carolina
Conditions: Refractory Depression, Treatment Resistant Depression
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
Recruiting
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia symptoms and ameliorating depressive symptoms in persons with mild to moderate TBI and comorbid Post-Traumatic Stress Symptoms (PTSS) and insomnia symptoms in a 360 patients. Participants will undergo as... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/14/2024
Locations: Womack Army Medical Center, Fort Bragg, North Carolina
Conditions: Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression
Recruiting
The purpose of this research study is to study closed-loop transcranial alternating current stimulation (tACS) to determine its effects on symptoms of depression in people with major depressive disorder.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
05/09/2024
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Depression, Major Depressive Disorder, tACS
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients who are experiencing major depressive episodes (MDEs) associated with a primary diagnosis of bipolar I or bipolar II disorder as confirmed by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL), according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM 5).
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
04/22/2024
Locations: Clinical Site, Kinston, North Carolina
Conditions: Bipolar Depression
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)
Recruiting
The objective of this study is to collect data to finalize the development of MEB-001 software as a medical device. The data collected in this study will be used to develop MEB-001 machine learning algorithms by training the algorithms to match the patient's demographic and clinical information, and the objective physiological signals (i.e., electroencephalogram (EEG) and electrocardiogram (ECG)) recorded during PSG with the diagnosis of cMDE performed through the MINI neuropsychiatric evaluatio... Read More
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
04/02/2024
Locations: Medbridge Healthcare, Clayton, North Carolina +2 locations
Conditions: Depressive Episode, Depression, Depressive Disorder, Depressive Disorder, Major, Depression Mild
Wellness App for Sleep Disturbance in Hematological Cancer Patients
Recruiting
In a randomized controlled trial (RCT), the investigators will recruit participants to an 8-week "app-based wellness" intervention, followed by a 12-week follow-up period. The investigators will recruit a total of 276 self-declared Chronic Hematological Cancer (CHC) patients who (representative of age, race/ethnicity, and gender) will be on stable CHC pharmacologic therapy (if any), self-identify as sleep disturbed (>5 on Pittsburgh Sleep Quality Index), do not have a sleep disorder diagnosis, d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2024
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Conditions: Cancer, Sleep Disturbance, Anxiety, Depression, Inflammation, Fatigue
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: The Center for Neuropsychiatry and Brain Stimulation (CNBS) ARC Health, Cary, North Carolina +2 locations
Conditions: Treatment Resistant Depression
Depression, Aging, Stress and Heart Health Study
Recruiting
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and... Read More
Gender:
Female
Ages:
Between 44 years and 55 years
Trial Updated:
01/31/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Menopause, Depression, Heart Disease in Women, Stress
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
Recruiting
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Gender:
Female
Ages:
Between 45 years and 55 years
Trial Updated:
01/24/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Depression, Psychosis, Anhedonia