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Depression Paid Clinical Trials in North Carolina
A listing of 20 Depression clinical trials in North Carolina actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 20
The state of North Carolina currently has 20 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Durham, Charlotte, Winston-Salem and Chapel Hill.
Featured Trial
Type 2 Diabetes Clinical Trial
Recruiting
Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.
Conditions:
Type 2 Diabetes
Diabetes Mellitus Type 2 in Obese
Diabetes Type Two
Type 2 Diabetes Mellitus
Diabete Type 2
Featured Offer
Lose Weight with GLP-1 Medications
Recruiting
Policy Lab has partnered with CareGLP to offer trusted access to GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
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As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Chronic Cough Study
Recruiting
Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.
Conditions:
Chronic Cough
Refractory or Unexplained Chronic Cough
Cough
Asthma
Allergic Asthma
Featured Trial
Depression Clinical Trial
Recruiting
Join us in researching a potential investigational treatment for Depression. Reimbursement for study-related expenses may be available to you.
Qualifying participants:
•Are between 18-65
•Have been experiencing a major depressive episode forat least a month
Qualifying participants:
•Are between 18-65
•Have been experiencing a major depressive episode forat least a month
Conditions:
Depression
Major Depressive Disorder
Depressive Disorder
Depressive Symptoms
Depressive Disorder
Featured Trial
Bipolar Study for Patients Aged 10 to 17
Recruiting
A new short-term study is enrolling children and teens (ages 10-17) with bipolar depression. To pre-qualify, participants must meet the following criteria:
- Male or female patients 10 to 17 years of age
- Have primary diagnosis of Bipolar I or Bipolar II Disorder
- Have a history of at least one manic or hypomanic episode
- Current major depressive episode is ≥ 4 weeks and less than 12 months in duration
- Male or female patients 10 to 17 years of age
- Have primary diagnosis of Bipolar I or Bipolar II Disorder
- Have a history of at least one manic or hypomanic episode
- Current major depressive episode is ≥ 4 weeks and less than 12 months in duration
Conditions:
Bipolar Disorder
Bipolar Depression
Bipolar I Disorder
Depression
Bipolar
Project neuroARTEMIS
Recruiting
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this... Read More
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
04/30/2025
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
Recruiting
The purpose of this research study is to test the study drug, NORA520, as a possible treatment for severe postpartum depression (PPD). The trial aims to determine:
* How well NORA520 is tolerated and what side effects it may cause
* If NORA520 reduces depressive symptoms in subjects with severe PPD
* The amount of NORA520 in the blood at various times after taking the study drug; this provides information that helps determine how often NORA520 should be taken
* In a subset of subjects, the amou... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/28/2025
Locations: Monroe Biomedical Research, Monroe, North Carolina
Conditions: Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression, Post-Natal Depression
RE104 Safety and Efficacy Study in Postpartum Depression
Recruiting
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms in participants with moderate-to-severe postpartum depression (PPD) as compared to active-placebo.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/18/2025
Locations: Reunion Investigational Site, Chapel Hill, North Carolina +1 locations
Conditions: Postpartum Depression
Neuroscience of Psychotherapy for Depression
Recruiting
The goal of this study is to learn the extent to which client-therapist brain activity may synchronize during a psychosocial intervention for depression symptoms.
The study will compare behavioral activation, a client-centered type of cognitive-behavioral therapy, to psychoeducation which delivers information on strategies to recover from depression symptoms.
Participants will answer questions about their mental and physical health, attend one psychosocial intervention session receiving either... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
04/14/2025
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Depression
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
Recruiting
The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects on symptoms of depression in people with major depressive disorder.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/11/2025
Locations: Carolina Center for Neurostimulation, Chapel Hill, North Carolina
Conditions: Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
Recruiting
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are:
* What are the obstacles to enrolling patients and prescribing anti-depressants among older adults?
* Is it possible to start prescribing SNRI medication upon discharge?
* What is the prevalence of depressive symptoms amongst patients with different types of injuries... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/31/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Depression in Old Age, Fragility Fracture
Collaborative Care for Anxiety and Depression in Epilepsy
Recruiting
This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
03/24/2025
Locations: New Dawn Psychiatric Services PLLC /ID# 229782, Kinston, North Carolina
Conditions: Depression, Bipolar I Disorder
Wellness App for Sleep Disturbance in Hematological Cancer Patients
Recruiting
In a randomized controlled trial (RCT), the investigators will recruit participants to an 8-week "app-based wellness" intervention, followed by a 12-week follow-up period. The investigators will recruit a total of 276 self-declared Chronic Hematological Cancer (CHC) patients who (representative of age, race/ethnicity, and gender) will be on stable CHC pharmacologic therapy (if any), self-identify as sleep disturbed (\>5 on Pittsburgh Sleep Quality Index), do not have a sleep disorder diagnosis,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
Recruiting
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).
Gender:
FEMALE
Ages:
Between 45 years and 55 years
Trial Updated:
02/24/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
Recruiting
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia symptoms and ameliorating depressive symptoms in persons with mild to moderate TBI and comorbid Post-Traumatic Stress Symptoms (PTSS) and insomnia symptoms in a 360 patients. Participants will undergo as... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Womack Army Medical Center, Fort Bragg, North Carolina
Conditions: Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress, Sleep, Memory Impairment, Cognitive Behavioral Therapy, Concussion, Brain, Head Injury, Brain Injury Traumatic Mild
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: The Center for Neuropsychiatry and Brain Stimulation (CNBS) ARC Health, Cary, North Carolina +2 locations
Conditions: Treatment Resistant Depression