The state of Pennsylvania currently has 53 active clinical trials seeking participants for Diabetes research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
Diabetes Reversal and the Subgingival Microbiota
Recruiting
This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth. This is an important question since bacterial changes may impact oral health. Participants will attend a screening and baseline visit prior to bariatric surgery and three post bariatric surgery appointments (3 weeks post, 6 months post and 1 year to 18 months post). Samples coll... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
07/30/2024
Locations: Temple University, Philadelphia, Pennsylvania +1 locations
Conditions: Diabetes type2, Bariatric Surgery Candidate
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
Recruiting
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Genetics Disease, Type2 Diabetes, Heart Failure
Pharmacogenetics of Response to GLP1R Agonists
Recruiting
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA. Pharmacodynamic responses to GLP1R agonist will be assessed by conducting frequently sampled intravenous glucose tolerance tests (FSIGT) both before and after semaglutide for six weeks. The proposal proposes two specific aims: Specific Aim #1. To identify genetic variants associated with effects of a GLP1R agonist to enhance glucose-stimulated first... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
06/20/2024
Locations: Amish Research Clinic, Lancaster, Pennsylvania
Conditions: Obesity, Diabetes Type 2
Pilot Brief Communal Coping Intervention for Adults With Type 2 Diabetes
Recruiting
The investigators plan to develop a communal coping intervention aimed at instilling a shared appraisal of diabetes and increasing patient-partner collaboration. To that end, the investigators will pilot the first randomized clinical trial of a brief communal coping intervention among couples in which one person has T12
Gender:
All
Ages:
18 years and above
Trial Updated:
06/10/2024
Locations: Carnegie Mellon University, Pittsburgh, Pennsylvania
Conditions: Diabetes Mellitus, Type 2
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
Recruiting
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
06/09/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes
Recruiting
This research study aims to test a financial and health insurance iHERO Toolkit for young adults with type1 diabetes. The iHERO Toolkit was developed over one year with the type 1 diabetes community, The Diabetes Link organization, and experts. Now, the investigators want to understand the impact of the iHERO Toolkit on diabetes self-management, financial stress, and health insurance literacy outcomes. The investigators are doing this study because it will help to better understand how to suppor... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
05/24/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Type 1 Diabetes
Empagliflozin Treatment in Kidney Transplant Recipients
Recruiting
Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging. Patient death with existing kidney graft function occurs in about half of all recipients over time. This is primarily due to the development of cardiovascular disease in a patient population with multiple preexisting cardiac disease risk factors. There has been little progress i... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
05/14/2024
Locations: VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, Pennsylvania
Conditions: Kidney Transplant, Type 2 Diabetes
Screening and Nutrition for Patients With Diabetes: A Pilot Study
Recruiting
The goal of this project is to provide diabetes self-management education and support (DSMES) and simultaneously address food insecurity for a high-risk, ethnically diverse adult population who participate in a food pantry. This project will utilize a Community-Based Participatory Research model (CBPR). Community representatives will engage in project implementation by participating in designing the messaging for cultural impact and advising in study operations. This intervention targets food pa... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: Villanova University, Villanova, Pennsylvania
Conditions: Diabetes Mellitus
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Recruiting
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function am... Read More
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
04/10/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Type2 Diabetes, Type 2 Diabetes Mellitus in Obese, Dysglycemia, Microvascular Complications, Brain Structure, Obesity, Childhood, Diabetes in Adolescence, Inflammation, Insulin Resistance, Overweight, Childhood, Cognitive Decline
Gastric Volume in Patients on GLP-1 Medications
Recruiting
Evaluating gastric volume in patients on GLP-1 RA medications
Gender:
All
Ages:
18 years and below
Trial Updated:
03/25/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Diabetes
Pilot Brief Communal Coping Intervention for Adults With Type 1 Diabetes
Recruiting
We plan to develop a communal coping intervention aimed at instilling a shared appraisal of diabetes and increasing patient-partner collaboration. To that end, we will pilot the first randomized clinical trial of a brief communal coping intervention among couples in which one person has T1D
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: Carnegie Mellon University, Pittsburgh, Pennsylvania
Conditions: Diabetes Mellitus, Type 1
Alternate Measures of Glucose During OGTT Testing for CFRD
Recruiting
Although early detection and treatment of cystic fibrosis-related diabetes (CFRD) can lead to significant clinical improvements and prolong life, rates of screening are poor likely due to the burdensome nature of oral glucose tolerance testing (OGTT). The investigators propose to assess the feasibility and accuracy of two screening tools, continuous glucose monitoring (CGM) and a home OGTT kit (GTT@home). If this pilot study reveals acceptable accuracy of either device, this study will allow for... Read More
Gender:
All
Ages:
10 years and above
Trial Updated:
03/05/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Cystic Fibrosis, Cystic Fibrosis-related Diabetes