The city of Philadelphia, Pennsylvania, currently has 26 active clinical trials seeking participants for Diabetes research studies.
Diabetes Reversal and the Subgingival Microbiota
Recruiting
This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth. This is an important question since bacterial changes may impact oral health. Participants will attend a screening and baseline visit prior to bariatric surgery and three post bariatric surgery appointments (3 weeks post, 6 months post and 1 year to 18 months post). Samples coll... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
07/30/2024
Locations: Temple University, Philadelphia, Pennsylvania +1 locations
Conditions: Diabetes type2, Bariatric Surgery Candidate
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
Recruiting
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Genetics Disease, Type2 Diabetes, Heart Failure