The city of Philadelphia, Pennsylvania, currently has 29 active clinical trials seeking participants for Diabetes research studies.
Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes (START 2)
NCT06419803
Recruiting
The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM). Our goal is to compare a Strict and permissive threshold. The Strict study arm target range will be 65-120 mg/dL, with time in range goal of 70%. The permissive study arm target range will be 65-140 mg/dL, with target time in range goal of 70%.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Gestational Diabetes, Pregnancy Related
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Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes
NCT06419777
Recruiting
The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM). Our goal is to compare a strict and permissive threshold. The strict threshold is defined as two abnormal values or more over a one-week period (two fasting values elevated, two of the same post prandial values elevated, or 1 fasting and 1 post prandial value elevated), whereas the permissive threshold is defined as 50% o... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Gestational Diabetes, Pregnancy Related
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Phenotyping Genetic Risk for Type 2 Diabetes
NCT04024631
Recruiting
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Gender:
ALL
Ages:
Between 10 years and 70 years
Trial Updated:
08/14/2024
Locations: Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Diabetes Mellitus, Type 2, Genetics
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Diabetes Reversal and the Subgingival Microbiota
NCT05501093
Recruiting
This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth. This is an important question since bacterial changes may impact oral health. Participants will attend a screening and baseline visit prior to bariatric surgery and three post bariatric surgery appointments (3 weeks post, 6 months post and 1 year to 18 months post). Samples coll... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
07/30/2024
Locations: Temple University, Philadelphia, Pennsylvania +1 locations
Conditions: Diabetes type2, Bariatric Surgery Candidate
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Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
NCT04323189
Recruiting
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Genetics Disease, Type2 Diabetes, Heart Failure
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