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Diabetes Clinical Trials in Philadelphia, PA
A listing of 30 Diabetes clinical trials in Philadelphia, PA actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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The city of Philadelphia, Pennsylvania, currently has 30 active clinical trials seeking participants for Diabetes research studies.
Featured Trial
New High Blood Pressure (Hypertension) Clinical Trials
Recruiting
This campaign features 7 hypertension studies for adults with high blood pressure that remains uncontrolled despite medication. Studies are available for a range of cardiovascular profiles, including people taking multiple blood pressure medications or living with heart or vascular disease.
Inclusion Criteria:
- Diagnosed with high blood pressure (hypertension)
- Age 18+ (one study requires participants to be 55+)
- Blood pressure remains elevated despite taking medication (typically systolic 135 mmHg or higher), or your doctor has expressed concerns about your blood pressure
- Currently taking 2 or more blood pressure medications
- Have cardiovascular disease (such as a previous heart attack, coronary artery disease, stroke, or peripheral artery disease) or certain cardiovascular risk factors, including diabetes, chronic kidney disease (CKD), atrial fibrillation (AF), or smoking (study dependent)
- Stable body weight for the past 3 months
Find out if you qualify today.
Inclusion Criteria:
- Diagnosed with high blood pressure (hypertension)
- Age 18+ (one study requires participants to be 55+)
- Blood pressure remains elevated despite taking medication (typically systolic 135 mmHg or higher), or your doctor has expressed concerns about your blood pressure
- Currently taking 2 or more blood pressure medications
- Have cardiovascular disease (such as a previous heart attack, coronary artery disease, stroke, or peripheral artery disease) or certain cardiovascular risk factors, including diabetes, chronic kidney disease (CKD), atrial fibrillation (AF), or smoking (study dependent)
- Stable body weight for the past 3 months
Find out if you qualify today.
Conditions:
Hypertension Multi
Hypertension
Pulmonary Hypertension
Ocular Hypertension
Pulmonary Arterial Hypertension
Featured Trial
New Obesity Clinical Studies Now Recruiting
Recruiting
We are seeking participants for multiple clinical trials focused on obesity and metabolic health, evaluating investigational treatments for weight management and diabetes. Studies are looking for adults with obesity, with or without type 2 diabetes, who are not currently taking GLP-1 medications or other weight-loss treatments.
See if you qualify today.
See if you qualify today.
Conditions:
Obesity Multi
Obesity
Overweight and Obesity
Morbid Obesity
Childhood Obesity
Featured Trial
Multiple Type 2 Diabetes Studies Now Recruiting
Recruiting
We are seeking participants for 14 clinical studies investigating new treatments for type 2 diabetes (T2DM) and related conditions including obesity and fatty liver disease (MASH/NAFLD). Studies are looking for adults with a confirmed T2DM diagnosis who are not well-controlled or are seeking improved management, spanning a range of disease stages from early/diet-managed to long-standing and multiply medicated.
See if you qualify today.
See if you qualify today.
Conditions:
Type 2 Diabetes Multi
Type 2 Diabetes
Diabete Type 2
Diabetic Nephropathy Type 2
Type 2 Diabetes Mellitus
Featured Trial
Reduce Heart Failure Risk – See if You Qualify for a Study
Recruiting
We are currently looking for individuals aged 18 and older to take part in a heart disease research study. You may be eligible if you have been diagnosed with all of the following:
• Cardiovascular Disease
• Type 2 Diabetes
• High Blood Pressure
This study is exploring an investigational medication that may help reduce the risk of heart-related complications.
If you’re interested in learning more, you can see if you pre-qualify today.
• Cardiovascular Disease
• Type 2 Diabetes
• High Blood Pressure
This study is exploring an investigational medication that may help reduce the risk of heart-related complications.
If you’re interested in learning more, you can see if you pre-qualify today.
Conditions:
Heart Diseases
Congenital Heart Disease
Coronary Heart Disease
Ischemic Heart Disease
Heart Disease
Featured Trial
Now Recruiting: Cardiovascular Disease (CVD) Clinical Studies
Recruiting
We are seeking participants for 31 cardiovascular disease (CVD) studies covering conditions such as high blood pressure (hypertension), atherosclerotic heart disease, high cholesterol (hyperlipidemia), heart failure, and type 2 diabetes with CVD. The studies are recruiting adults ages 18 and older who have been diagnosed with one or more of these conditions and are currently receiving treatment.
See if you qualify today.
See if you qualify today.
Conditions:
CVD Multi
CVD
Cardiovascular Disease
Cardiovascular Diseases
High Blood Pressure
Featured Therapy
Unique Treatment for High Blood Pressure
Worried about high blood pressure? Think beyond typical high blood pressure treatments.
People who may be candidates for this procedure:
• Are at least 18 years old
• Have been unable to manage their high blood pressure with medications or lifestyle changes alone¹
Learn about a safe and effective procedure that may help reduce high blood pressure. See if you qualify today.
¹ Kandzari DE, et al. J Am Coll Cardiol. Nov 7, 2023;82(19):1809-1823.
People who may be candidates for this procedure:
• Are at least 18 years old
• Have been unable to manage their high blood pressure with medications or lifestyle changes alone¹
Learn about a safe and effective procedure that may help reduce high blood pressure. See if you qualify today.
¹ Kandzari DE, et al. J Am Coll Cardiol. Nov 7, 2023;82(19):1809-1823.
Conditions:
High Blood Pressure
High Blood Pressure (& [Essential Hypertension])
High Blood Pressure (Hypertension).
Hypertension
Essential Hypertension
Sleep and Glycemic Control in Type 2 Diabetes Adolescents
Recruiting
The primary objective is to determine the cross-sectional relationship between sleep duration (as measured by 14 days of actigraphy) and glycemic control in an adolescent Type 2 Diabetes (T2DM) cohort (age 12-20y, n=67). A secondary objective is to determine if a loss-framed incentive for achieving sleep goals can increase sleep duration in 15 adolescent patients diagnosed with T2DM with insufficient sleep. Another secondary objective is to test if increasing sleep duration leads to improved gly... Read More
Gender:
ALL
Ages:
Between 12 years and 20 years
Trial Updated:
03/11/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Type 2 Diabetes
Low Dose Fat-Induced Insulin Resistance
Recruiting
The primary goal of this study is to determine the dose of fatty acids that acutely induces mild insulin resistance in healthy volunteers. We hypothesize that a low-dose of fatty acid infusion (Intralipid/heparin) will cause a mild insulin resistance. The dose of fatty acid infusion that reliably causes mild insulin resistance will be selected for use in future studies.
Gender:
ALL
Ages:
Between 18 years and 44 years
Trial Updated:
03/07/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Diabetes Mellitus, Type 2, Insulin Resistance, Insulin Sensitivity
Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes (START 2)
Recruiting
The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM). Our goal is to compare a Strict and permissive threshold. The Strict study arm target range will be 65-120 mg/dL, with time in range goal of 70%. The permissive study arm target range will be 65-140 mg/dL, with target time in range goal of 70%.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Gestational Diabetes, Pregnancy Related
Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes
Recruiting
The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM). Our goal is to compare a strict and permissive threshold. The strict threshold is defined as two abnormal values or more over a one-week period (two fasting values elevated, two of the same post prandial values elevated, or 1 fasting and 1 post prandial value elevated), whereas the permissive threshold is defined as 50% o... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Gestational Diabetes, Pregnancy Related
Phenotyping Genetic Risk for Type 2 Diabetes
Recruiting
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Gender:
ALL
Ages:
Between 10 years and 70 years
Trial Updated:
08/14/2024
Locations: Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Diabetes Mellitus, Type 2, Genetics
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
Recruiting
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Genetics Disease, Type2 Diabetes, Heart Failure
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