There are currently 1864 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
NCT06578637
Recruiting
The aim of this study is to evaluate the potential of BHB supplementation as a novel strategy to impede the development and progression of intestinal adenomas in individuals with FAP, thus reducing the need for frequent upper endoscopies and colonoscopies, and potentially preventing the need for risk-reducing surgical intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/21/2024
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: FAP, Familial Adenomatous Polyposis
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Consent for Use of Stored Patient Specimens for Future Testing
NCT00031408
Recruiting
The purpose of this study is to obtain informed consent to use stored human biological materials (HBM) (e.g., blood and other tissues) for future studies that may include genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/20/2024
Locations: Penn Therapeutics CRS (6201), Philadelphia, Pennsylvania +3 locations
Conditions: HIV Infections
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Guaranteed Income and Financial Treatment
NCT06611982
Recruiting
The goal of this clinical trial is to learn if providing advanced cancer patients with $1000/month for 12 months will improve cancer outcomes. The main questions it aims to answer are: To what extent does receiving $1000/month additional income reduce financial hardship? To what extent does receiving $1000/month additional income improve quality of life? Does receiving $1000/month additional income improve survival outcomes? Participants will: Receive $1000/month for 12 months Complete a surv... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania +1 locations
Conditions: Cancer, Financial Hardship, Quality of Life
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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
NCT04095663
Recruiting
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized, but are willing to contribute information about their outcomes. The goal of the COSMID trial is to answer the question:... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/20/2024
Locations: Penn Medicine, Philadelphia, Pennsylvania
Conditions: Diverticulitis
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Radiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast Cancer
NCT04837209
Recruiting
This research study is looking to see whether the combination of Dostarlimab and Niraparib plus Radiation Therapy (RT) is safe and effective in participants with metastatic triple negative breast cancer. The names of the study treatment involved in this study are: * Dostarlimab * Niraparib * Radiation Therapy (RT), which is given per standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/19/2024
Locations: University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Breast Cancer, Triple Negative Breast Cancer
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Screening Emotions in Adolescents at the Hospital for mTBI
NCT06370520
Recruiting
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or worsening mental health conditions. The main aims the study wish to answer are: * Does the adolescent have new or worsening depression or anxiety defined as a change from their previous medical history using self-reported questionnaires at either one or... Read More
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
09/19/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage, Head Injury Trauma, Brain Injury Traumatic Focal With Loss of Consciousness, Skull Fractures, Diffuse Axonal Injury, Intracranial Hemorrhages, Head Injury
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A Study to Investigate Safety and Tolerability of NDX-3315 and NDX-3324 in Healthy Participants and Patients with Eosinophilic Esophagitis
NCT05757856
Recruiting
An open-label phase 2 study to assess the safety and exploratory diagnostic performance of the oral radiopharmaceutical agent NDX-3315 and NDX-3324 in healthy participants and patients with eosinophilic esophagitis (EoE).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/18/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Eosinophilic Esophagitis
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Telemedicine in Early Childhood Constraint Therapy in Cerebral Palsy
NCT04997109
Recruiting
This study assesses two active treatments in different sequences and a standard of care group among infants with cerebral palsy.
Gender:
ALL
Ages:
Between 4 months and 13 months
Trial Updated:
09/18/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Cerebral Palsy
Register for Updates
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
NCT06582693
Recruiting
The goal of this clinical trial is to compare the reach and effectiveness of the Refer2Quit intervention for increasing tobacco use treatment and quit rates among household members who smoke versus a treatment as usual group. This clinical trial also aims to study household member and pediatric patient characteristics that are associated with reach and effectiveness of Refer2Quit.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Smoking, Smoking Cessation, Second Hand Tobacco Smoke
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Rheumatoid Arthritis Shared Decision Making
NCT05530694
Recruiting
Shared decision making is the first overarching principle for the treat to target guidelines for rheumatoid arthritis (RA) and has been proposed as a potential mechanism to reduce health disparities, however there is little evidence to inform effective ways to implement this practice in the care of Veterans with RA. The purpose of this project is to evaluate the effectiveness of a multi-component shared decision making intervention on RA disease activity, adherence to RA medications and patient... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia, Pennsylvania
Conditions: Rheumatoid Arthritis
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Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
NCT05975671
Recruiting
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when va... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/17/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy, Sepsis, Severe, Septic Shock, Septic Syndrome
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First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
NCT06554795
Recruiting
A Phase 1/2a First-in-Human Study of DB-1419 in Advanced/Metastatic Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/17/2024
Locations: Site USA05-0, Philadelphia, Pennsylvania
Conditions: Solid Tumor, Adult
Register for Updates