There are currently 1875 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
NCT05707663
Recruiting
The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations... Read More
Gender:
ALL
Ages:
Between 6 years and 30 years
Trial Updated:
12/04/2024
Locations: Children's Hospital of Philadelphia with the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Juvenile Huntington Disease, Juvenile-Onset Huntington Disease
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Diagnostic Utility of SGLT1/2 Inhibition to Facilitate Myocardial Glucose Suppression
NCT06510894
Recruiting
This is a pilot mechanistic study of the diagnostic utility of sodium-glucose cotransporter-1/2 inhibition (SGLT1/2) on myocardial glucose suppression on FDG PET/CT. The investigators will test whether the addition of a SGLT1/2 inhibitor (SGLT1/2i) plus the standard dietary modification (ketogenic diet) will provide enhanced myocardial glucose suppression. The primary objective is to assess rates of complete myocardial glucose suppression (MGS) with 7 days of sotagliflozin 400 mg QD among health... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/04/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Cardiac Sarcoidosis
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CEUS for Blunt Abdominal Trauma in Children
NCT03490929
Recruiting
Children with blunt abdominal trauma often get a CT as the first line imaging to evaluate for intra-abdominal organ injury. CT scans have some downsides with regard to radiation exposure, costs, and need for transport. Contrast enhanced ultrasonography has recently shown some promise as a way to detect intra-abdominal organ injury and may be able to replace the need for conventional CT scanning, without the need for ionizing radiation and the ability to be performed at the bedside.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
12/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Trauma Abdomen
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Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
NCT03864068
Recruiting
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
12/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance, Glucose Intolerance, Metabolic Complication
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Optimizing Tobacco Use Treatment for PLWHA
NCT04176172
Recruiting
The advent of anti-retroviral therapy (ART) for people living with HIV/AIDS (PLWHA) substantially improved life expectancy but has also led to the critical need to address modifiable risk factors associated with cancer and cardiovascular disease, such as tobacco smoking. HIV-infected smokers lose more life-years due to tobacco use than they do to their HIV infection. There have been relatively few studies of tobacco use treatments for PLWHA and systematic reviews show that there are insufficien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: HIV/AIDS, Nicotine Dependence
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Does Vaginal Delivery of Combined Hormonal Contraception Affect the Risk of Metabolic Syndrome in Overweight/obese Women with PCOS
NCT04257500
Recruiting
A prospective study to determine the metabolic effects of the contraceptive vaginal ring among overweight and obese women with polycystic ovary syndrome (PCOS). We will recruit a total of 40 participants and study use of the vaginal ring over a 4-month period.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
12/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Polycystic Ovary Syndrome
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Obesity and Pediatric Multiple Sclerosis
NCT04593082
Recruiting
Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental i... Read More
Gender:
ALL
Ages:
Between 10 years and 20 years
Trial Updated:
12/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Multiple Sclerosis
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The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)
NCT05499507
Recruiting
The overarching goal of our proposal is to reduce disparities in perinatal cardiovascular disease risk factors among Black women utilizing a community-driven, social ecological framework.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: Temple University/Temple Health, Philadelphia, Pennsylvania
Conditions: Pregnancy Related, Hypertension, Obesity, Racism
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Electrical Stimulation for the Treatment of Glaucoma
NCT05626491
Recruiting
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma. Open-Angle Glaucoma is a disease where the nerves in the back of your eye die off faster than expected regardless of your eye pressure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2024
Locations: Wills Eye Hospital, Philadelphia, Pennsylvania
Conditions: Glaucoma, Glaucoma, Open-Angle
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STXBP1 and SYNGAP1 Related Disorders Natural History Study
NCT06555965
Recruiting
The purpose of this study is to find out more about STXBP1 and SYNGAP1 related disorders. The information gathered by this study will be used to prepare for clinical treatment trials. The primary objective of the study is to better define and outline the clinical spectrum of STXBP1 and SYNGAP1 through detailed developmental, seizure, and quality of life assessments as an extension of routine clinical care.
Gender:
ALL
Ages:
All
Trial Updated:
11/27/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Genetic Disease, STXBP1 Encephalopathy With Epilepsy, SYNGAP1-Related Intellectual Disability
Register for Updates
A Single Dose, Open-Label, Dose-escalation Study of the Safety and Imaging Characteristics of LS301-IT for Intraoperative Imaging of Lung Cancer
NCT06713564
Recruiting
The aim of this Phase 1b study is to investigate the safety and fluorescence signal of a single dose of LS301-IT, a novel fluorescence imaging agent developed by Integro Theranostics (IT), administered by slow intravenous (IV) administration in patients undergoing surgical thoracoscopy and resection of lung cancer. Safety is the primary objective of this study, followed by the evaluation of the fluorescence signal as it relates to dose level and dosing time interval.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Lung Cancers
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A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
NCT03588975
Recruiting
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of patients aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the knee.
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
11/26/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee, Osteochondritis Dissecans (OCD)
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