There are currently 1875 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
The PREDICTOR Study: Assessing Diagnostic Predictors of Airway Collapse in Patients With Obstructive Sleep Apnea
NCT05428839
Recruiting
This study is an exploratory, multicenter study of up to 300 subjects diagnosed with obstructive sleep apnea who are being evaluated for airway surgery. Subjects will undergo standard evaluation for airway surgery as part of standard of care. In addition to the standard airway assessment, a simple, non-invasive measurement of the width of the inside of each subjects mouth will be performed. This measurement takes 2-3 minutes to perform.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/15/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Sleep Apnea, Obstructive
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Infusion System for Hepatic Cancer
NCT04684862
Recruiting
This is a single-site, open-label continued access study/treatment protocol under a treatment IDE. In addition to treating patients, the primary objective of this study is to assess the safety of using the Medtronic SynchroMed II programmable pump combined with the Intera tapered catheter for hepatic artery infusion (HAI) of a standard chemotherapy (FUDR) drug for adults with a clinical or biopsy-proven diagnosis of colorectal cancer metastatic to the liver or intrahepatic cholangiocarcinoma. A... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Colorectal Cancer Metastatic to Liver, Intrahepatic Cholangiocarcinoma
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CT Evaluation of Carotid Plaque Components
NCT05764772
Recruiting
The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard. The main question\[s\] it aims to answer are: 1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation softwa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/14/2024
Locations: University of Pennsylvania Hospital, Philadelphia, Pennsylvania
Conditions: Carotid Plaque
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The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
NCT06264154
Recruiting
This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
10/11/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Smoking, Tobacco Use, Cigarette Smoking, E-Cig Use
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Integrating Telehealth to Advance Lung Cancer Screening
NCT06638554
Recruiting
The goal of this pragmatic trial is to learn if telehealth strategies can increase shared decision-making (SDM) for lung cancer screening (LCS). It will also learn about the equity of these strategies by conducting non-inferiority analysis by race and sex. The main questions it aims to answer are: 1. Does patient outreach using synchronous and asynchronous telehealth strategies increase completion of SDM visits for LCS? 2. Is the effectiveness of these telehealth strategies similar by race and... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
10/10/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Early Detection of Cancer, Telemedicine, Decision Making
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Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension
NCT04039464
Recruiting
The investigators' central hypothesis is that early combination therapy with two PAH-specific oral therapies that have been shown to be well tolerated in the pediatric population, sildenafil and bosentan, will result in better World Health Organization (WHO) functional class at 12 months after initiation of PAH treatment than therapy with sildenafil alone.
Gender:
ALL
Ages:
Between 3 months and 18 years
Trial Updated:
10/09/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pediatric Pulmonary Hypertension
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Natural History Study of Infantile and Juvenile GM1 Gangliosidosis (GM1) Patients
NCT04041102
Recruiting
Owing to the rarity, severity, speed of progression and fatal prognosis of infantile and juvenile GM1, there is a limited understanding of overall disease progression and meaningful outcome measures. This study aims to build a natural history data set through collection of a number of clinical, imaging, and laboratory assessments that may be specific predictors of GM1 disease progression and clinical outcome. Having a GM1 natural history data set can inform potential efficacy endpoints and bioma... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/09/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: GM1 Gangliosidosis
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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD
NCT05359562
Recruiting
Studies show that hormones affect the brain's fear extinction network, which is relevant for therapy involving exposure and response prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD). This study will examine the effect of delivering EX/RP to women during different phases in their menstrual cycle to determine the effects of hormones on the fear extinction network and on their OCD symptoms.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
10/09/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: OCD
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TumorGlow Intraoperative Molecular Imaging (IMI)
NCT04723810
Recruiting
This is a Phase 1/2 study in patients presenting with any solid tumor and/or diseased tissue even benign nodules presumed to be resectable and at risk for recurrence on pre-operative assessment who are considered to be good surgical candidates to evaluate the safety and efficacy of the image-guided surgery using indocyanine green for intramolecular imaging of solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Tumor, Solid
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Imaging Retinal Vasculature in Infant Eyes
NCT05558059
Recruiting
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants,... Read More
Gender:
ALL
Ages:
2 months and below
Trial Updated:
10/08/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Retinopathy of Prematurity
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Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants with SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS)
NCT06100276
Recruiting
This is the study of AMT-162 in Participants with SOD1-ALS and is designed to evaluate the safety, tolerability, and exploratory efficacy of intrathecally administered gene therapy AMT-162. AMT-162-001 is a Phase 1/2, multi-center, single ascending dose study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Conditions: Amyotrophic Lateral Sclerosis
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18F-Fluciclovine PET-MRI in High-grade Glioma
NCT05553041
Recruiting
The purpose of this study is to see if 18F-fluciclovine (Axumin®) PET imaging is useful and safe in the management of children with High Grade Gliomas. Investigators seek to determine if this imaging will help doctors tell the difference between tumor growth (progression) and other tumor changes that can occur after treatment.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
10/04/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Glioma, High Grade Glioma, Glioma, Malignant, Glioma Intracranial, Diffuse Glioma
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