There are currently 1846 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
NCT05539196
Recruiting
This registry is a prospective, multicenter, international, single arm, observational post-approval registry with follow-up at 3, 6, and 12 months, and annually for 5 years. The proposed registry will enroll 60 subjects and will be conducted at approximately 10 centers worldwide.
Gender:
ALL
Ages:
Between 30 years and 99 years
Trial Updated:
05/30/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Movement Disorders, Neurology, Parkinsons Disease
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Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)
NCT04197596
Recruiting
BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or with primary immunodeficiencies (PID).
Gender:
ALL
Ages:
Between 1 month and 79 years
Trial Updated:
05/30/2024
Locations: Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Viral Infection, Primary Immune Deficiency Disorder
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Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia
NCT03971799
Recruiting
This phase 1/2 trial aims to determine the safety and feasibility of antiCD33 chimeric antigen receptor (CAR) expressing T cells (CD33CART) in children and adolescents/young adults (AYAs) with relapsed/refractory acute myeloid leukemia (AML). The trial will be done in two phases: Phase 1 will determine the maximum tolerated dose of CD33CART cells using a 3+3 trial design, with dose-escalation for autologous products separated from dose-escalation for an allogeneic arm. Phase 2 is an expansion ph... Read More
Gender:
ALL
Ages:
Between 1 year and 35 years
Trial Updated:
05/29/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Acute Myelogenous Leukemia
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DISE: Phenotyping Obstruction Patterns
NCT05050383
Recruiting
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction. The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, they will use o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Obstructive Sleep Apnea
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Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
NCT06442488
Recruiting
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal volume, minute ventilation, and duration of apnea in a noisy environment. Sensor accuracy will be measured with adaptive filtering and active noise cancellation turned on versus turned off.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/29/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Respiratory Insufficiency, Clinical Deterioration
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Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking
NCT05679349
Recruiting
This clinical trial tests how well providing education improves screening for lung cancer in patients with a history of smoking. Screenings may help doctors find lung cancer sooner when it may be easier to treat. Education and counseling may be an effective method to help providers and patients learn about lung cancer screening. Providing education and decision counseling to providers and patients may increase lung cancer screening.
Gender:
ALL
Ages:
Between 50 years and 77 years
Trial Updated:
05/29/2024
Locations: Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Lung Carcinoma, Tobacco-Related Carcinoma
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Parkinson's Foundation PD GENEration Genetic Registry
NCT04994015
Recruiting
Development of a central repository for PD-related genomic data for future research.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Parkinson's Disease
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Genomic Risk in Retroperitoneal Sarcoma
NCT06436846
Recruiting
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Retroperitoneal Liposarcoma, Soft Tissue Sarcoma
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Abbott DBS Post-Market Study of Outcomes for Indications Over Time
NCT04071847
Recruiting
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
05/24/2024
Locations: Thomas Jefferson Department or Neurosurgery, Philadelphia, Pennsylvania
Conditions: Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
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Pencil Beam Scanning in Patients With Renal Tumors
NCT03810651
Recruiting
This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.
Gender:
ALL
Ages:
Between 0 years and 30 years
Trial Updated:
05/24/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Renal Tumor, Wilms Tumor
Register for Updates
RH Genotype Matched RBC Transfusions
NCT04156893
Recruiting
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
Gender:
ALL
Ages:
6 months and above
Trial Updated:
05/24/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Sickle Cells Disease
Register for Updates
Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
NCT04146051
Recruiting
This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Myasthenia Gravis, Generalized
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