There are currently 1875 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
NCT03568669
Recruiting
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain. In CCHS, neurocognitive function has been of great concern because of the potential for repeated hypoxemia and hypercarbia in activities of daily living in addition to hypoventilation with related hypoxemia and hypercarbia during sleep. As the world's leading referral center for CCHS, the Center for Autonomic Medicine in Pediatrics (CA... Read More
Gender:
ALL
Ages:
Between 3 years and 85 years
Trial Updated:
08/06/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease, CCHS With Neural Crest Tumor, CCHS With Neuroblastoma
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Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
NCT06545084
Recruiting
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the oste... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/05/2024
Locations: Penn Dental Medicine, Philadelphia, Pennsylvania
Conditions: Apical Periodontitis
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OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
NCT02523118
Recruiting
The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with EoE, EoG, EoN and EoC normally undergo endoscopy and/or colonoscopy where cells are collected for microscopic analysis. Treatments are then decided based on how the cells look. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms. We want to see if scores on standard questionnaires can give us an i... Read More
Gender:
ALL
Ages:
3 years and above
Trial Updated:
08/02/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis, Eosinophilic Colitis, Eosinophilic Gastritis, Eosinophilic Gastroenteritis
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Improving Care, Accelerating Recovery and Education
NCT06233747
Recruiting
The goal of this clinical trial is to test the I-CARE program in children who are in a medical hospital awaiting inpatient mental health treatment. The main questions it aims to answer are: * Can the I-CARE program be used at the medical hospitals and do the patients and hospital staff like the program? * Does the I-CARE program lower patients' emotional distress, thoughts about suicide or suicide attempts? Patients will complete as many of the 7 I-CARE videos as possible during their stay at... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
08/01/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Mental Health Disorder, Suicide Attempt, Suicidal Ideation, Emergency Psychiatric
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In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma
NCT05636540
Recruiting
This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment. A pre-treatment 18F-FluorThanatrace (\[18F\]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic therapy. PET/CT imaging will be used to evaluate PARP-1 expression in sites of pheochromocytoma or paraganglioma using the investigational radiotracer \[18F\]FTT. This is an observational study in that \... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2024
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Pheochromocytoma, Paraganglioma
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Apremilast for Erythema Multiforme
NCT05875714
Recruiting
This study is recruiting patients with chronic, treatment resistant erythema multiforme (EM), which is a disease that can affect the skin and mucous membranes (mucocutaneous). EM often impacts quality of life with pain, anorexia, hospitalization, and related long-term issues. While there are medications used to treat EM, no single therapeutic agent has been consistently effective for long-term management of disease. Apremilast (trade name: Otezla) is approved to treat Bechet's Disease, a differe... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/30/2024
Locations: Perelman Center For Advanced Medicine, Philadelphia, Pennsylvania
Conditions: Erythema Multiforme
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Medical Residents Learning Weight Management Counseling Skills
NCT06529666
Recruiting
The goal of this study is to addresses the lack of weight management training physicians receive during their residency training. The main questions it aims to answer are: * How affective is the MRWeight curriculum at increasing medical residents weight management counseling (WMC) skills. * Evaluate residents' adoption of WMC skills in encounters with their patients * what would be the best way to get residents to adopt the WMC skills Residents in the comparison group will receive a course on o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Weight Management, Patient Counseling, Video Communication Asssessments
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QOL and Sarcopenia in Patients With Ascites
NCT05726747
Recruiting
Clinical data regarding quality of life in patients with refractory ascites is limited and preceded the development of newer questionnaires that may be more robust. One primary objective of this study is to study changes in quality in life in a prospective fashion using newer general and ascites-specific quality of life survey instruments specific to benign and malignant etiologies. Sarcopenia is a condition that is prevalent in cancer and cirrhosis. Current data is retrospective and associativ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2024
Locations: University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: Ascites Hepatic, Ascites, Malignant
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Caffeine Consumption in Glaucoma Patients and Healthy Subjects
NCT03675412
Recruiting
Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
07/25/2024
Locations: Wills Eye Glaucoma Service, Philadelphia, Pennsylvania
Conditions: Glaucoma, Primary Open Angle
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Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
NCT04323189
Recruiting
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/25/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Genetics Disease, Type2 Diabetes, Heart Failure
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Evaluating Home Testing Devices for the Management of Glaucoma
NCT05325996
Recruiting
With the advancement in technology we have the opportunity of performing the glaucoma testing at home to monitor the disease. The purpose of this study is evaluating the feasibility and patient acceptance of home testing with head mounted perimetry; detection of progression with head mounted perimetry vs office based perimetry; and monitoring the eye pressure measured by patients at home using a portable tonometer.
Gender:
ALL
Ages:
Between 20 years and 80 years
Trial Updated:
07/25/2024
Locations: Wills Eye Hospital, Philadelphia, Pennsylvania
Conditions: Glaucoma, Open-Angle
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Defining Treatment Outcomes and Genetic Architecture in Idiopathic Toe Walking*
NCT06305689
Recruiting
To compare and contrast the clinical, gait and parent-reported outcomes following either non-operative (casting) or operative treatment for children with idiopathic toe walking (ITW) and determine whether there are specific genes associated with ITW.
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
07/23/2024
Locations: Shriners Hospitals for Children, Philadelphia, Pennsylvania
Conditions: Idiopathic Toe Walking
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